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Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population
Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brai...
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| Published in: | Neurological sciences 2022-04, Vol.43 (4), p.2611-2620 |
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| container_issue | 4 |
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| container_title | Neurological sciences |
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| creator | Sezer, Eda Can Demirdöğen, Birsen Demirkaya, Şeref Bulut, Giray Akkulak, Merve Evin, Emre Adalı, Orhan |
| description | Background
Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS.
Methods
Patients with MS (
n
= 191) and controls (
n
= 100) were tested using the PCR–RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs.
Results
The minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (
P
= .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (
P
= .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects.
Conclusion
CYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk. |
| doi_str_mv | 10.1007/s10072-021-05597-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2575070791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2638312272</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e560ee8d96294e686110b5d7abd3a717dfacde21e8453adeeeb48f653f1d9de43</originalsourceid><addsrcrecordid>eNp9ksuO1DAQRSMEYh7wAyyQJTbdEgE_42TZaoaHNBJIDAtWkTuuEM84cXAlA_1Z_Ag_xAb3dAOCkdjYVvn6XFfpZtkjRp8xSvVz3K08p5zlVKlK5-xOdsxURXMhdXn3cGallkfZCeIlpZRJJu5nR0IqWSjGjrMfK8TQODO5MJDQkqYLHnCCGDzR37_l3dbG8HXrDQJZrD--0yu2JGMMfUgaMga_7UMcO4c9WUQUJS0LqpfEDPYvFJfvb6FksWO5YYrJmt9iaSU5FUvyxU0dQYhzT7wbncWn5NpNpncDeUE8XINPlZ1fP_vJjR4INj6ZokMSHV4lBzJ1QC7meOWwSz7j7G_6fZDda41HeHjYT7MPL88u1q_z87ev3qxX53kjtJpyUAUFKG1V8EpCURaM0Y2y2mysMJpp25rGAmdQSiWMBYCNLNtCiZbZyoIUp9liz01z-zynkdS9wwa8NwOEGWuutKKa6ool6ZN_pJdhjkP6Xc0LUQrGueZJxfeqJrWJEdp6jK43cVszWu9CUe-jUado1DfRqHfoxwf0vOnB_n7yKwtJIPYCTFfDJ4h_vP-D_QlhOscu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2638312272</pqid></control><display><type>article</type><title>Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population</title><source>Springer Link</source><creator>Sezer, Eda ; Can Demirdöğen, Birsen ; Demirkaya, Şeref ; Bulut, Giray ; Akkulak, Merve ; Evin, Emre ; Adalı, Orhan</creator><creatorcontrib>Sezer, Eda ; Can Demirdöğen, Birsen ; Demirkaya, Şeref ; Bulut, Giray ; Akkulak, Merve ; Evin, Emre ; Adalı, Orhan</creatorcontrib><description>Background
Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS.
Methods
Patients with MS (
n
= 191) and controls (
n
= 100) were tested using the PCR–RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs.
Results
The minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (
P
= .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (
P
= .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects.
Conclusion
CYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-021-05597-1</identifier><identifier>PMID: 34546511</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Alleles ; Cholesterol ; Cholesterol 24-Hydroxylase - genetics ; Cholesterol 7-alpha-Hydroxylase - genetics ; Gene frequency ; Gene polymorphism ; Humans ; Hydroxylase ; Introns ; Lipids ; Lipids - blood ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - genetics ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Promoter Regions, Genetic ; Psychiatry ; Serum lipids ; Single-nucleotide polymorphism ; Turkey - epidemiology ; Vitamin D ; Vitamin D - blood</subject><ispartof>Neurological sciences, 2022-04, Vol.43 (4), p.2611-2620</ispartof><rights>Fondazione Società Italiana di Neurologia 2021</rights><rights>2021. Fondazione Società Italiana di Neurologia.</rights><rights>Fondazione Società Italiana di Neurologia 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e560ee8d96294e686110b5d7abd3a717dfacde21e8453adeeeb48f653f1d9de43</citedby><cites>FETCH-LOGICAL-c375t-e560ee8d96294e686110b5d7abd3a717dfacde21e8453adeeeb48f653f1d9de43</cites><orcidid>0000-0002-5805-7419 ; 0000-0001-8484-1146 ; 0000-0003-2834-7682 ; 0000-0002-0986-1144 ; 0000-0002-4052-1666 ; 0000-0002-1536-6123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34546511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sezer, Eda</creatorcontrib><creatorcontrib>Can Demirdöğen, Birsen</creatorcontrib><creatorcontrib>Demirkaya, Şeref</creatorcontrib><creatorcontrib>Bulut, Giray</creatorcontrib><creatorcontrib>Akkulak, Merve</creatorcontrib><creatorcontrib>Evin, Emre</creatorcontrib><creatorcontrib>Adalı, Orhan</creatorcontrib><title>Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Background
Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS.
Methods
Patients with MS (
n
= 191) and controls (
n
= 100) were tested using the PCR–RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs.
Results
The minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (
P
= .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (
P
= .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects.
Conclusion
CYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk.</description><subject>Alleles</subject><subject>Cholesterol</subject><subject>Cholesterol 24-Hydroxylase - genetics</subject><subject>Cholesterol 7-alpha-Hydroxylase - genetics</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Humans</subject><subject>Hydroxylase</subject><subject>Introns</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - genetics</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>Psychiatry</subject><subject>Serum lipids</subject><subject>Single-nucleotide polymorphism</subject><subject>Turkey - epidemiology</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9ksuO1DAQRSMEYh7wAyyQJTbdEgE_42TZaoaHNBJIDAtWkTuuEM84cXAlA_1Z_Ag_xAb3dAOCkdjYVvn6XFfpZtkjRp8xSvVz3K08p5zlVKlK5-xOdsxURXMhdXn3cGallkfZCeIlpZRJJu5nR0IqWSjGjrMfK8TQODO5MJDQkqYLHnCCGDzR37_l3dbG8HXrDQJZrD--0yu2JGMMfUgaMga_7UMcO4c9WUQUJS0LqpfEDPYvFJfvb6FksWO5YYrJmt9iaSU5FUvyxU0dQYhzT7wbncWn5NpNpncDeUE8XINPlZ1fP_vJjR4INj6ZokMSHV4lBzJ1QC7meOWwSz7j7G_6fZDda41HeHjYT7MPL88u1q_z87ev3qxX53kjtJpyUAUFKG1V8EpCURaM0Y2y2mysMJpp25rGAmdQSiWMBYCNLNtCiZbZyoIUp9liz01z-zynkdS9wwa8NwOEGWuutKKa6ool6ZN_pJdhjkP6Xc0LUQrGueZJxfeqJrWJEdp6jK43cVszWu9CUe-jUado1DfRqHfoxwf0vOnB_n7yKwtJIPYCTFfDJ4h_vP-D_QlhOscu</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Sezer, Eda</creator><creator>Can Demirdöğen, Birsen</creator><creator>Demirkaya, Şeref</creator><creator>Bulut, Giray</creator><creator>Akkulak, Merve</creator><creator>Evin, Emre</creator><creator>Adalı, Orhan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5805-7419</orcidid><orcidid>https://orcid.org/0000-0001-8484-1146</orcidid><orcidid>https://orcid.org/0000-0003-2834-7682</orcidid><orcidid>https://orcid.org/0000-0002-0986-1144</orcidid><orcidid>https://orcid.org/0000-0002-4052-1666</orcidid><orcidid>https://orcid.org/0000-0002-1536-6123</orcidid></search><sort><creationdate>20220401</creationdate><title>Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population</title><author>Sezer, Eda ; Can Demirdöğen, Birsen ; Demirkaya, Şeref ; Bulut, Giray ; Akkulak, Merve ; Evin, Emre ; Adalı, Orhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e560ee8d96294e686110b5d7abd3a717dfacde21e8453adeeeb48f653f1d9de43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alleles</topic><topic>Cholesterol</topic><topic>Cholesterol 24-Hydroxylase - genetics</topic><topic>Cholesterol 7-alpha-Hydroxylase - genetics</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Humans</topic><topic>Hydroxylase</topic><topic>Introns</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - genetics</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>Psychiatry</topic><topic>Serum lipids</topic><topic>Single-nucleotide polymorphism</topic><topic>Turkey - epidemiology</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sezer, Eda</creatorcontrib><creatorcontrib>Can Demirdöğen, Birsen</creatorcontrib><creatorcontrib>Demirkaya, Şeref</creatorcontrib><creatorcontrib>Bulut, Giray</creatorcontrib><creatorcontrib>Akkulak, Merve</creatorcontrib><creatorcontrib>Evin, Emre</creatorcontrib><creatorcontrib>Adalı, Orhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sezer, Eda</au><au>Can Demirdöğen, Birsen</au><au>Demirkaya, Şeref</au><au>Bulut, Giray</au><au>Akkulak, Merve</au><au>Evin, Emre</au><au>Adalı, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>43</volume><issue>4</issue><spage>2611</spage><epage>2620</epage><pages>2611-2620</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background
Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS.
Methods
Patients with MS (
n
= 191) and controls (
n
= 100) were tested using the PCR–RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs.
Results
The minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (
P
= .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (
P
= .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects.
Conclusion
CYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>34546511</pmid><doi>10.1007/s10072-021-05597-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5805-7419</orcidid><orcidid>https://orcid.org/0000-0001-8484-1146</orcidid><orcidid>https://orcid.org/0000-0003-2834-7682</orcidid><orcidid>https://orcid.org/0000-0002-0986-1144</orcidid><orcidid>https://orcid.org/0000-0002-4052-1666</orcidid><orcidid>https://orcid.org/0000-0002-1536-6123</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Neurological sciences, 2022-04, Vol.43 (4), p.2611-2620 |
| issn | 1590-1874 1590-3478 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2575070791 |
| source | Springer Link |
| subjects | Alleles Cholesterol Cholesterol 24-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - genetics Gene frequency Gene polymorphism Humans Hydroxylase Introns Lipids Lipids - blood Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Neurology Neuroradiology Neurosciences Neurosurgery Original Article Polymorphism Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic Psychiatry Serum lipids Single-nucleotide polymorphism Turkey - epidemiology Vitamin D Vitamin D - blood |
| title | Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population |
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