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Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation
Acute lung injury (ALI) is an important public health problem. The present work investigated whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant (Lauraceae), modulates experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B in lipopolys...
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| Published in: | Journal of natural products (Washington, D.C.) D.C.), 2021-08, Vol.84 (8), p.2282-2294 |
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| creator | Bittencourt-Mernak, Márcia I Pinheiro, Nathalia M da Silva, Rafael C Ponci, Vitor Banzato, Rosana Pinheiro, Aruanã J M C R Olivo, Clarice R Tibério, Iolanda F L C Lima Neto, Lídio G Santana, Fernanda P R Lago, João H G Prado, Carla M |
| description | Acute lung injury (ALI) is an important public health problem. The present work investigated whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant
(Lauraceae), modulates experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B
in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were evaluated. The lung and systemic inflammatory profile, lung function, and possible mechanisms involved in BALB/C male mice (6-8 weeks) with ALI induced by LPS instillation (5 mg/kg) was assayed. Dehydrodieugenol B did not affect the cell viability and inhibited the increase in NO release and IL-1β and IL-6 gene expression induced by LPS.
, both compounds reduced lung edema, inflammatory cells, and the IL-6 and IL-1 β levels in bronchoalveolar lavage fluid, as well as reduced inflammatory cell infiltration and those positive to iNOS, MMP-9, and TIMP-1, and reduced the collagen content and the 8-isoprostane expression in lung tissue. Eugenol and dehydrodieugenol B also inhibited the phosphorylation of Jc-Jun-NH2 terminal Kinase (JNK), a signaling protein involved in the MAPKinase pathway. There was no effect of these compounds in lung function. Therefore, eugenol and dehydrodieugenol B ameliorates several features of experimental ALI and could be considered as a pharmacological tool to ameliorate acute lung inflammation. |
| doi_str_mv | 10.1021/acs.jnatprod.1c00386 |
| format | article |
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(Lauraceae), modulates experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B
in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were evaluated. The lung and systemic inflammatory profile, lung function, and possible mechanisms involved in BALB/C male mice (6-8 weeks) with ALI induced by LPS instillation (5 mg/kg) was assayed. Dehydrodieugenol B did not affect the cell viability and inhibited the increase in NO release and IL-1β and IL-6 gene expression induced by LPS.
, both compounds reduced lung edema, inflammatory cells, and the IL-6 and IL-1 β levels in bronchoalveolar lavage fluid, as well as reduced inflammatory cell infiltration and those positive to iNOS, MMP-9, and TIMP-1, and reduced the collagen content and the 8-isoprostane expression in lung tissue. Eugenol and dehydrodieugenol B also inhibited the phosphorylation of Jc-Jun-NH2 terminal Kinase (JNK), a signaling protein involved in the MAPKinase pathway. There was no effect of these compounds in lung function. Therefore, eugenol and dehydrodieugenol B ameliorates several features of experimental ALI and could be considered as a pharmacological tool to ameliorate acute lung inflammation.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/acs.jnatprod.1c00386</identifier><identifier>PMID: 34264084</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Lung Injury - chemically induced ; Acute Lung Injury - drug therapy ; Animals ; Anisoles - pharmacology ; Brazil ; Eugenol - pharmacology ; Lauraceae - chemistry ; Lipopolysaccharides ; Male ; Mice ; Mice, Inbred BALB C ; Phytochemicals - pharmacology ; Plant Leaves - chemistry ; Pneumonia - chemically induced ; Pneumonia - drug therapy ; RAW 264.7 Cells</subject><ispartof>Journal of natural products (Washington, D.C.), 2021-08, Vol.84 (8), p.2282-2294</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-ddd8a3fbfcb9ff09ac38e9c74bdf74ecf9115f0555889d6d4c860f3beb587dc03</citedby><cites>FETCH-LOGICAL-c307t-ddd8a3fbfcb9ff09ac38e9c74bdf74ecf9115f0555889d6d4c860f3beb587dc03</cites><orcidid>0000-0003-1160-0442 ; 0000-0002-1193-8374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34264084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bittencourt-Mernak, Márcia I</creatorcontrib><creatorcontrib>Pinheiro, Nathalia M</creatorcontrib><creatorcontrib>da Silva, Rafael C</creatorcontrib><creatorcontrib>Ponci, Vitor</creatorcontrib><creatorcontrib>Banzato, Rosana</creatorcontrib><creatorcontrib>Pinheiro, Aruanã J M C R</creatorcontrib><creatorcontrib>Olivo, Clarice R</creatorcontrib><creatorcontrib>Tibério, Iolanda F L C</creatorcontrib><creatorcontrib>Lima Neto, Lídio G</creatorcontrib><creatorcontrib>Santana, Fernanda P R</creatorcontrib><creatorcontrib>Lago, João H G</creatorcontrib><creatorcontrib>Prado, Carla M</creatorcontrib><title>Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J Nat Prod</addtitle><description>Acute lung injury (ALI) is an important public health problem. The present work investigated whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant
(Lauraceae), modulates experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B
in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were evaluated. The lung and systemic inflammatory profile, lung function, and possible mechanisms involved in BALB/C male mice (6-8 weeks) with ALI induced by LPS instillation (5 mg/kg) was assayed. Dehydrodieugenol B did not affect the cell viability and inhibited the increase in NO release and IL-1β and IL-6 gene expression induced by LPS.
, both compounds reduced lung edema, inflammatory cells, and the IL-6 and IL-1 β levels in bronchoalveolar lavage fluid, as well as reduced inflammatory cell infiltration and those positive to iNOS, MMP-9, and TIMP-1, and reduced the collagen content and the 8-isoprostane expression in lung tissue. Eugenol and dehydrodieugenol B also inhibited the phosphorylation of Jc-Jun-NH2 terminal Kinase (JNK), a signaling protein involved in the MAPKinase pathway. There was no effect of these compounds in lung function. Therefore, eugenol and dehydrodieugenol B ameliorates several features of experimental ALI and could be considered as a pharmacological tool to ameliorate acute lung inflammation.</description><subject>Acute Lung Injury - chemically induced</subject><subject>Acute Lung Injury - drug therapy</subject><subject>Animals</subject><subject>Anisoles - pharmacology</subject><subject>Brazil</subject><subject>Eugenol - pharmacology</subject><subject>Lauraceae - chemistry</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Phytochemicals - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Pneumonia - chemically induced</subject><subject>Pneumonia - drug therapy</subject><subject>RAW 264.7 Cells</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9UdFu1DAQtCoQPQp_UFV-bB9yrOM4lzyW9oCTIkCCPkcbe32XKrHT2JG4v-CTcdUrTyvNzsxqZxi7FLAWkItPqMP60WGcZm_WQgPIqjxjK6FyyErI1Ru2AlHKLMHFOXsfwiMkDtTqHTuXRV4WUBUr9ndrLekYuLd8u-zJ-YGjM_yeDkeTnHs6gZ-5nf3Ivydy2s_IB1o0unhAjnvsXYi86Sc_-eEYUOsDzr0hft38_HWT7ZxZNBm-_TPR3I_kIg78Vi-ReLO4Pd85O-A4Yuy9-8DeWhwCfTzNC_bwZfv77lvW_Pi6u7ttMi1hEzNjTIXSdlZ3tbVQo5YV1XpTdMZuCtK2FkJZUEpVVW1KU-iqBCs76lS1MRrkBbt-8U35PS0UYjv2QdMwoCO_hDZXKUilJJSJWrxQ9exDmMm2U_oC52MroH3uok1dtK9dtKcukuzqdGHpRjL_Ra_hy38P-Yx_</recordid><startdate>20210827</startdate><enddate>20210827</enddate><creator>Bittencourt-Mernak, Márcia I</creator><creator>Pinheiro, Nathalia M</creator><creator>da Silva, Rafael C</creator><creator>Ponci, Vitor</creator><creator>Banzato, Rosana</creator><creator>Pinheiro, Aruanã J M C R</creator><creator>Olivo, Clarice R</creator><creator>Tibério, Iolanda F L C</creator><creator>Lima Neto, Lídio G</creator><creator>Santana, Fernanda P R</creator><creator>Lago, João H G</creator><creator>Prado, Carla M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1160-0442</orcidid><orcidid>https://orcid.org/0000-0002-1193-8374</orcidid></search><sort><creationdate>20210827</creationdate><title>Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation</title><author>Bittencourt-Mernak, Márcia I ; Pinheiro, Nathalia M ; da Silva, Rafael C ; Ponci, Vitor ; Banzato, Rosana ; Pinheiro, Aruanã J M C R ; Olivo, Clarice R ; Tibério, Iolanda F L C ; Lima Neto, Lídio G ; Santana, Fernanda P R ; Lago, João H G ; Prado, Carla M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-ddd8a3fbfcb9ff09ac38e9c74bdf74ecf9115f0555889d6d4c860f3beb587dc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Lung Injury - chemically induced</topic><topic>Acute Lung Injury - drug therapy</topic><topic>Animals</topic><topic>Anisoles - pharmacology</topic><topic>Brazil</topic><topic>Eugenol - pharmacology</topic><topic>Lauraceae - chemistry</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Phytochemicals - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Pneumonia - chemically induced</topic><topic>Pneumonia - drug therapy</topic><topic>RAW 264.7 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bittencourt-Mernak, Márcia I</creatorcontrib><creatorcontrib>Pinheiro, Nathalia M</creatorcontrib><creatorcontrib>da Silva, Rafael C</creatorcontrib><creatorcontrib>Ponci, Vitor</creatorcontrib><creatorcontrib>Banzato, Rosana</creatorcontrib><creatorcontrib>Pinheiro, Aruanã J M C R</creatorcontrib><creatorcontrib>Olivo, Clarice R</creatorcontrib><creatorcontrib>Tibério, Iolanda F L C</creatorcontrib><creatorcontrib>Lima Neto, Lídio G</creatorcontrib><creatorcontrib>Santana, Fernanda P R</creatorcontrib><creatorcontrib>Lago, João H G</creatorcontrib><creatorcontrib>Prado, Carla M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bittencourt-Mernak, Márcia I</au><au>Pinheiro, Nathalia M</au><au>da Silva, Rafael C</au><au>Ponci, Vitor</au><au>Banzato, Rosana</au><au>Pinheiro, Aruanã J M C R</au><au>Olivo, Clarice R</au><au>Tibério, Iolanda F L C</au><au>Lima Neto, Lídio G</au><au>Santana, Fernanda P R</au><au>Lago, João H G</au><au>Prado, Carla M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J Nat Prod</addtitle><date>2021-08-27</date><risdate>2021</risdate><volume>84</volume><issue>8</issue><spage>2282</spage><epage>2294</epage><pages>2282-2294</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Acute lung injury (ALI) is an important public health problem. The present work investigated whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant
(Lauraceae), modulates experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B
in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were evaluated. The lung and systemic inflammatory profile, lung function, and possible mechanisms involved in BALB/C male mice (6-8 weeks) with ALI induced by LPS instillation (5 mg/kg) was assayed. Dehydrodieugenol B did not affect the cell viability and inhibited the increase in NO release and IL-1β and IL-6 gene expression induced by LPS.
, both compounds reduced lung edema, inflammatory cells, and the IL-6 and IL-1 β levels in bronchoalveolar lavage fluid, as well as reduced inflammatory cell infiltration and those positive to iNOS, MMP-9, and TIMP-1, and reduced the collagen content and the 8-isoprostane expression in lung tissue. Eugenol and dehydrodieugenol B also inhibited the phosphorylation of Jc-Jun-NH2 terminal Kinase (JNK), a signaling protein involved in the MAPKinase pathway. There was no effect of these compounds in lung function. Therefore, eugenol and dehydrodieugenol B ameliorates several features of experimental ALI and could be considered as a pharmacological tool to ameliorate acute lung inflammation.</abstract><cop>United States</cop><pmid>34264084</pmid><doi>10.1021/acs.jnatprod.1c00386</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1160-0442</orcidid><orcidid>https://orcid.org/0000-0002-1193-8374</orcidid></addata></record> |
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| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Animals Anisoles - pharmacology Brazil Eugenol - pharmacology Lauraceae - chemistry Lipopolysaccharides Male Mice Mice, Inbred BALB C Phytochemicals - pharmacology Plant Leaves - chemistry Pneumonia - chemically induced Pneumonia - drug therapy RAW 264.7 Cells |
| title | Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation |
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