Loading…
Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor
Wood is one of the extensively used goods on the earth due to its large accessibility and usage in a wide range of human life. When woods are exposed to aquatic media, leachates are generated which may affect the quality of water and damage aquatic life into which they are discharged. This research...
Saved in:
| Published in: | Environmental science and pollution research international 2021-12, Vol.28 (47), p.67150-67158 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433 |
| container_end_page | 67158 |
| container_issue | 47 |
| container_start_page | 67150 |
| container_title | Environmental science and pollution research international |
| container_volume | 28 |
| creator | Sackey, Lyndon N.A. Mocová, Klára A. Petrová, Šárka Kočí, Vladimír |
| description | Wood is one of the extensively used goods on the earth due to its large accessibility and usage in a wide range of human life. When woods are exposed to aquatic media, leachates are generated which may affect the quality of water and damage aquatic life into which they are discharged. This research seeks to evaluate the toxicity of linden (
Tilia cordata
), larch (
Larix decidua
) from the Czech Republic, cedrela (
Cedrela odorata
) and emire (
Terminalia ivorensis
) from Ghana wood leachates to two aquatic organisms (
Desmodesmus subspicatus
and
Lemna minor
). In algal and duckweed toxicity tests, these plants were exposed to different concentrations of wood leachate with nutrient medium creating concentration rates, 20, 30, 45, 67, and 100% v/v. High concentration of phenols and heavy metals may have contributed to toxicity. It was observed that the various wood leachates were inhibitory to the growth rate of algae and duckweed with emire exhibiting the highest toxicity with IC
50
of 30.04% and 28.58% and larch the lowest toxicity with IC
50
of 51.18% and 49.57% in relation to growth rate and chlorophyll respectively, hence indicating confirmed and potential toxicity of the various wood leachates to the aquatic organisms. |
| doi_str_mv | 10.1007/s11356-021-15319-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2550631189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2605774369</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AQ8S8OKlmnQmyeYofsOCHvQc0jZZK22zNi2u_97orgoevGQC88w7w0PIIWennDF1FjkHITOW84wL4DpbbpAJlxwzhVpvkgnTiBkHxB2yG-MLYznTudomO4A5KhD5hDw8hmVd1sM7DZ6-hVDRxtny2Q6ODoHaZm4dvXSxDVV6xkjjWMRFXdoh_W1X0UVju4HOXNtZ2tZd6PfJlrdNdAfrukeerq8eL26z2f3N3cX5LCtBiSHzWldae1TIsPLCMwVgUXILqAucFoBTsEwrhlhpL7iUU12hK6TnDgEB9sjJKnfRh9fRxcG0dSxdk-5xYYwmF4JJ4HyqE3r8B30JY9-l60wumVAKQX5S-Yoq-xBj77xZ9HVr-3fDmfn0bVa-TfJtvnybZRo6WkePReuqn5FvwQmAFRBTq5u7_nf3P7EfqEOJ_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2605774369</pqid></control><display><type>article</type><title>Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor</title><source>ABI/INFORM Global</source><source>Springer Link</source><creator>Sackey, Lyndon N.A. ; Mocová, Klára A. ; Petrová, Šárka ; Kočí, Vladimír</creator><creatorcontrib>Sackey, Lyndon N.A. ; Mocová, Klára A. ; Petrová, Šárka ; Kočí, Vladimír</creatorcontrib><description>Wood is one of the extensively used goods on the earth due to its large accessibility and usage in a wide range of human life. When woods are exposed to aquatic media, leachates are generated which may affect the quality of water and damage aquatic life into which they are discharged. This research seeks to evaluate the toxicity of linden (
Tilia cordata
), larch (
Larix decidua
) from the Czech Republic, cedrela (
Cedrela odorata
) and emire (
Terminalia ivorensis
) from Ghana wood leachates to two aquatic organisms (
Desmodesmus subspicatus
and
Lemna minor
). In algal and duckweed toxicity tests, these plants were exposed to different concentrations of wood leachate with nutrient medium creating concentration rates, 20, 30, 45, 67, and 100% v/v. High concentration of phenols and heavy metals may have contributed to toxicity. It was observed that the various wood leachates were inhibitory to the growth rate of algae and duckweed with emire exhibiting the highest toxicity with IC
50
of 30.04% and 28.58% and larch the lowest toxicity with IC
50
of 51.18% and 49.57% in relation to growth rate and chlorophyll respectively, hence indicating confirmed and potential toxicity of the various wood leachates to the aquatic organisms.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-15319-x</identifier><identifier>PMID: 34247352</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algae ; Aquatic organisms ; Aquatic plants ; Aquatic Pollution ; Araceae ; Atmospheric Protection/Air Quality Control/Air Pollution ; Chlorophyll ; Desmodesmus subspicatus ; Duckweed ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Floating plants ; Growth rate ; Heavy metals ; Humans ; Leachates ; Lemna minor ; Metal concentrations ; Metals, Heavy ; Nutrient concentrations ; Phenols ; Plants ; Research Article ; Toxicity ; Toxicity testing ; Toxicity Tests ; Waste Water Technology ; Water damage ; Water Management ; Water Pollutants, Chemical - toxicity ; Water Pollution Control ; Water quality ; Wood</subject><ispartof>Environmental science and pollution research international, 2021-12, Vol.28 (47), p.67150-67158</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433</citedby><cites>FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2605774369/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2605774369?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,786,790,11715,27957,27958,36095,36096,44398,75252</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34247352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sackey, Lyndon N.A.</creatorcontrib><creatorcontrib>Mocová, Klára A.</creatorcontrib><creatorcontrib>Petrová, Šárka</creatorcontrib><creatorcontrib>Kočí, Vladimír</creatorcontrib><title>Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Wood is one of the extensively used goods on the earth due to its large accessibility and usage in a wide range of human life. When woods are exposed to aquatic media, leachates are generated which may affect the quality of water and damage aquatic life into which they are discharged. This research seeks to evaluate the toxicity of linden (
Tilia cordata
), larch (
Larix decidua
) from the Czech Republic, cedrela (
Cedrela odorata
) and emire (
Terminalia ivorensis
) from Ghana wood leachates to two aquatic organisms (
Desmodesmus subspicatus
and
Lemna minor
). In algal and duckweed toxicity tests, these plants were exposed to different concentrations of wood leachate with nutrient medium creating concentration rates, 20, 30, 45, 67, and 100% v/v. High concentration of phenols and heavy metals may have contributed to toxicity. It was observed that the various wood leachates were inhibitory to the growth rate of algae and duckweed with emire exhibiting the highest toxicity with IC
50
of 30.04% and 28.58% and larch the lowest toxicity with IC
50
of 51.18% and 49.57% in relation to growth rate and chlorophyll respectively, hence indicating confirmed and potential toxicity of the various wood leachates to the aquatic organisms.</description><subject>Algae</subject><subject>Aquatic organisms</subject><subject>Aquatic plants</subject><subject>Aquatic Pollution</subject><subject>Araceae</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Chlorophyll</subject><subject>Desmodesmus subspicatus</subject><subject>Duckweed</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Floating plants</subject><subject>Growth rate</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Leachates</subject><subject>Lemna minor</subject><subject>Metal concentrations</subject><subject>Metals, Heavy</subject><subject>Nutrient concentrations</subject><subject>Phenols</subject><subject>Plants</subject><subject>Research Article</subject><subject>Toxicity</subject><subject>Toxicity testing</subject><subject>Toxicity Tests</subject><subject>Waste Water Technology</subject><subject>Water damage</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><subject>Water quality</subject><subject>Wood</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNp9kE1LxDAQhoMoun78AQ8S8OKlmnQmyeYofsOCHvQc0jZZK22zNi2u_97orgoevGQC88w7w0PIIWennDF1FjkHITOW84wL4DpbbpAJlxwzhVpvkgnTiBkHxB2yG-MLYznTudomO4A5KhD5hDw8hmVd1sM7DZ6-hVDRxtny2Q6ODoHaZm4dvXSxDVV6xkjjWMRFXdoh_W1X0UVju4HOXNtZ2tZd6PfJlrdNdAfrukeerq8eL26z2f3N3cX5LCtBiSHzWldae1TIsPLCMwVgUXILqAucFoBTsEwrhlhpL7iUU12hK6TnDgEB9sjJKnfRh9fRxcG0dSxdk-5xYYwmF4JJ4HyqE3r8B30JY9-l60wumVAKQX5S-Yoq-xBj77xZ9HVr-3fDmfn0bVa-TfJtvnybZRo6WkePReuqn5FvwQmAFRBTq5u7_nf3P7EfqEOJ_Q</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Sackey, Lyndon N.A.</creator><creator>Mocová, Klára A.</creator><creator>Petrová, Šárka</creator><creator>Kočí, Vladimír</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor</title><author>Sackey, Lyndon N.A. ; Mocová, Klára A. ; Petrová, Šárka ; Kočí, Vladimír</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algae</topic><topic>Aquatic organisms</topic><topic>Aquatic plants</topic><topic>Aquatic Pollution</topic><topic>Araceae</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Chlorophyll</topic><topic>Desmodesmus subspicatus</topic><topic>Duckweed</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Floating plants</topic><topic>Growth rate</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Leachates</topic><topic>Lemna minor</topic><topic>Metal concentrations</topic><topic>Metals, Heavy</topic><topic>Nutrient concentrations</topic><topic>Phenols</topic><topic>Plants</topic><topic>Research Article</topic><topic>Toxicity</topic><topic>Toxicity testing</topic><topic>Toxicity Tests</topic><topic>Waste Water Technology</topic><topic>Water damage</topic><topic>Water Management</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water Pollution Control</topic><topic>Water quality</topic><topic>Wood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sackey, Lyndon N.A.</creatorcontrib><creatorcontrib>Mocová, Klára A.</creatorcontrib><creatorcontrib>Petrová, Šárka</creatorcontrib><creatorcontrib>Kočí, Vladimír</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sackey, Lyndon N.A.</au><au>Mocová, Klára A.</au><au>Petrová, Šárka</au><au>Kočí, Vladimír</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>28</volume><issue>47</issue><spage>67150</spage><epage>67158</epage><pages>67150-67158</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Wood is one of the extensively used goods on the earth due to its large accessibility and usage in a wide range of human life. When woods are exposed to aquatic media, leachates are generated which may affect the quality of water and damage aquatic life into which they are discharged. This research seeks to evaluate the toxicity of linden (
Tilia cordata
), larch (
Larix decidua
) from the Czech Republic, cedrela (
Cedrela odorata
) and emire (
Terminalia ivorensis
) from Ghana wood leachates to two aquatic organisms (
Desmodesmus subspicatus
and
Lemna minor
). In algal and duckweed toxicity tests, these plants were exposed to different concentrations of wood leachate with nutrient medium creating concentration rates, 20, 30, 45, 67, and 100% v/v. High concentration of phenols and heavy metals may have contributed to toxicity. It was observed that the various wood leachates were inhibitory to the growth rate of algae and duckweed with emire exhibiting the highest toxicity with IC
50
of 30.04% and 28.58% and larch the lowest toxicity with IC
50
of 51.18% and 49.57% in relation to growth rate and chlorophyll respectively, hence indicating confirmed and potential toxicity of the various wood leachates to the aquatic organisms.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34247352</pmid><doi>10.1007/s11356-021-15319-x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2021-12, Vol.28 (47), p.67150-67158 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2550631189 |
| source | ABI/INFORM Global; Springer Link |
| subjects | Algae Aquatic organisms Aquatic plants Aquatic Pollution Araceae Atmospheric Protection/Air Quality Control/Air Pollution Chlorophyll Desmodesmus subspicatus Duckweed Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Floating plants Growth rate Heavy metals Humans Leachates Lemna minor Metal concentrations Metals, Heavy Nutrient concentrations Phenols Plants Research Article Toxicity Toxicity testing Toxicity Tests Waste Water Technology Water damage Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Water quality Wood |
| title | Toxicity of wood leachate to algae Desmodesmus subspicatus and plant Lemna minor |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T17%3A22%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toxicity%20of%20wood%20leachate%20to%20algae%20Desmodesmus%20subspicatus%20and%20plant%20Lemna%20minor&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Sackey,%20Lyndon%20N.A.&rft.date=2021-12-01&rft.volume=28&rft.issue=47&rft.spage=67150&rft.epage=67158&rft.pages=67150-67158&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-021-15319-x&rft_dat=%3Cproquest_cross%3E2605774369%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c375t-f99d99f47404df5f0733a461a349b48b3483a097044d9f516689d4eb6f1e43433%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2605774369&rft_id=info:pmid/34247352&rfr_iscdi=true |