Whole-genome sequence analyses by a new easy-to-use software solution support the suspicion of a neonatal ward outbreak of methicillin-resistant Staphylococcus aureus (MRSA) and transmission between hospitals

To the Editor–Methicillin-resistant Staphylococcus aureus (MRSA) occasionally causes outbreaks in hospitals, often in departments where newborns receive treatment.1,2 Hospital-acquired infections by MRSA may have a lethal outcome3 and expenses for infection control measures for containing hospital o...

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Published in:Infection control and hospital epidemiology 2022-07, Vol.43 (7), p.947-949
Main Authors: Slott Jensen, Marie Louise, Chen, Ming, Detlefsen, Mette, Kudsk Klitgaard, Janne, Andersen, Thomas Emil, Kemp, Michael
Format: Article
Language:English
Subjects:
Antibiotics
Cluster analysis
Disease control
Drug resistance
Genes
Genomes
Letter to the Editor
Mutation
Nosocomial infections
Staphylococcus infections
Surveillance
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description To the Editor–Methicillin-resistant Staphylococcus aureus (MRSA) occasionally causes outbreaks in hospitals, often in departments where newborns receive treatment.1,2 Hospital-acquired infections by MRSA may have a lethal outcome3 and expenses for infection control measures for containing hospital outbreaks may become very high.4 Surveillance of MRSA is essential for early detection and interruption of transmission. For S. aureus, results include individual MLST ST, antibiotic resistance mechanisms (resistance genes and mutations associated with resistance), and virulence gene profiles. [...]all isolates from hospital B in the outbreak cluster were cultured later than the isolate from the index patient. [...]the higher resolution obtained from cgMLST did support suspicion of transmission of the outbreak strain between the hospitals but did not confirm this taking place via transfer of the index patient from hospital B. Another 2 clusters were detected among isolates from hospital B (Fig. 1).
doi_str_mv 10.1017/ice.2021.123
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subjects Antibiotics
Cluster analysis
Disease control
Drug resistance
Genes
Genomes
Letter to the Editor
Mutation
Nosocomial infections
Staphylococcus infections
Surveillance
title Whole-genome sequence analyses by a new easy-to-use software solution support the suspicion of a neonatal ward outbreak of methicillin-resistant Staphylococcus aureus (MRSA) and transmission between hospitals
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