Antiproliferative potential of Andean Berry (Vaccinium meridionale Swartz) juice in combination with Aspirin in human SW480 colon adenocarcinoma cells

Andean Berry (Vaccinium meridionale Sw.) is a South American fruit rich in phytochemicals with promising anti‐cancer properties as co‐adjuvants to nonsteroidal anti‐inflammatory drugs such as Aspirin. This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combina...

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Published in:Journal of food biochemistry 2021-06, Vol.45 (6), p.e13760-n/a
Main Authors: Arango‐Varela, Sandra S., Luzardo‐Ocampo, Ivan, Reyes‐Dieck, Camilo, Yahia, Elhadi M., Maldonado‐Celis, Maria E.
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Language:English
Subjects:
antiproliferative
apoptosis
Aspirin
colorectal cancer
Vaccinium meridionale Swartz
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Luzardo‐Ocampo, Ivan
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description Andean Berry (Vaccinium meridionale Sw.) is a South American fruit rich in phytochemicals with promising anti‐cancer properties as co‐adjuvants to nonsteroidal anti‐inflammatory drugs such as Aspirin. This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combination with Aspirin in human SW480 colon adenocarcinoma cells. ABJ primarily contained 3,4‐dihydroxybenzoic and chlorogenic acids. The combined treatment of ABJ (IC50: 30.0 ± 0.11%) and Aspirin (IC50: 20.0 ± 0.57) exhibited a higher (p 
doi_str_mv 10.1111/jfbc.13760
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This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combination with Aspirin in human SW480 colon adenocarcinoma cells. ABJ primarily contained 3,4‐dihydroxybenzoic and chlorogenic acids. The combined treatment of ABJ (IC50: 30.0 ± 0.11%) and Aspirin (IC50: 20.0 ± 0.57) exhibited a higher (p &lt; .01) antiproliferative effect than each counterpart. Moreover the same mixture displayed a lower reduced glutathione/oxidized glutathione ratio (GSH/GSSG) than the untreated cells. ABJ‐Aspirin combination induced late apoptosis stage without stimulating mitochondrial depolarization and prompted phosphatidylserine relocalization. These results emphasize the antiproliferative potential of bioactive compounds from ABJ and Aspirin combinations. Practical applications Natural products such as Andean Berry (V. meridionale Sw.) juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non‐steroidal anti‐inflammatory drugs, currently employed in cancer treatment, to prevent its side effects. The high abundance of polyphenols from this underutilized berry could stimulate the standardization of its production and industrial exploitation to be transformed into suitable food products delivering natural bioactive compounds with potential anti‐cancer effects in vitro. 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Practical applications Natural products such as Andean Berry (V. meridionale Sw.) juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non‐steroidal anti‐inflammatory drugs, currently employed in cancer treatment, to prevent its side effects. The high abundance of polyphenols from this underutilized berry could stimulate the standardization of its production and industrial exploitation to be transformed into suitable food products delivering natural bioactive compounds with potential anti‐cancer effects in vitro. 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Practical applications Natural products such as Andean Berry (V. meridionale Sw.) juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non‐steroidal anti‐inflammatory drugs, currently employed in cancer treatment, to prevent its side effects. The high abundance of polyphenols from this underutilized berry could stimulate the standardization of its production and industrial exploitation to be transformed into suitable food products delivering natural bioactive compounds with potential anti‐cancer effects in vitro. Bioactive components from Andean Berry (V. meridionale) juice, combined with Aspirin, exhibited antiproliferative effects against human SW480 colon adenocarcinoma cells, involving reactive oxygen species activation, decreasing reduced glutathione and oxidized glutathione, and potentially triggering apoptosis.</abstract><cop>United States</cop><pmid>33974285</pmid><doi>10.1111/jfbc.13760</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8033-3520</orcidid><orcidid>https://orcid.org/0000-0003-2422-3439</orcidid><orcidid>https://orcid.org/0000-0002-3557-8975</orcidid><oa>free_for_read</oa></addata></record>
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subjects antiproliferative
apoptosis
Aspirin
colorectal cancer
Vaccinium meridionale Swartz
title Antiproliferative potential of Andean Berry (Vaccinium meridionale Swartz) juice in combination with Aspirin in human SW480 colon adenocarcinoma cells
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