Loading…
Intramuscular fatty infiltration and physical function in controlled acromegaly
Introduction Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders. Objective To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients an...
Saved in:
| Published in: | European journal of endocrinology 2021-07, Vol.185 (1), p.167-177 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-b396t-91520156a63778c0bcb40951613fdd2bedbfa08e39a1893dac6afb83fd4586853 |
|---|---|
| cites | |
| container_end_page | 177 |
| container_issue | 1 |
| container_start_page | 167 |
| container_title | European journal of endocrinology |
| container_volume | 185 |
| creator | Martel-Duguech, Luciana Alonso-Pérez, Jorge Bascuñana, Helena Díaz-Manera, Jordi Llauger, Jaume Nuñez-Peralta, Claudia Montesinos, Paula Webb, Susan M Valassi, Elena |
| description | Introduction Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders. Objective To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction. Methods In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Results Intramuscular fat fraction was greater in patients than controls (P < 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (P < 0.05). The greater fat fraction in the combined anterior–posterior compartment and in each muscle was associated with worse performance on timed up and go (P < 0.05). The fat fraction in the anterior–posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (β = 0.737 P < 0.001). Conclusions Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship. |
| doi_str_mv | 10.1530/EJE-21-0209 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2522616165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2553568868</sourcerecordid><originalsourceid>FETCH-LOGICAL-b396t-91520156a63778c0bcb40951613fdd2bedbfa08e39a1893dac6afb83fd4586853</originalsourceid><addsrcrecordid>eNp9kL1PAyEcQInR2Fqd3M0lLibmlI-DcqNpqtY06aKJGwEOlIaDetwN_e-lVh0cnCA_Hi_wADhH8AZRAm_nT_MSoxJiWB-AMaqmdck4eT0EY8hhVVasIiNwktIaQpT38BiMCKkp5AyNwWoR-k62Q9KDl11hZd9vCxes83ncuxgKGZpi875NTktf2CHor6kLhY75avTeNIXUXWzNm_TbU3BkpU_m7HudgJf7-fPssVyuHhazu2WpSM36skYUQ0SZZGQ65RoqrSpYU8QQsU2DlWmUlZAbUkvEa9JIzaRVPB9WlDNOyQRc7b2bLn4MJvWidUkb72UwcUgCU4xZ1rEdevkHXcehC_l1maKEMp6NmbreU_krKXXGik3nWtltBYJi11nkzgIjseuc6Ytv56Ba0_yyP2EzgPaAcjFpZ0LvbC74r_QT_7aIaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2553568868</pqid></control><display><type>article</type><title>Intramuscular fatty infiltration and physical function in controlled acromegaly</title><source>Oxford Journals Online</source><creator>Martel-Duguech, Luciana ; Alonso-Pérez, Jorge ; Bascuñana, Helena ; Díaz-Manera, Jordi ; Llauger, Jaume ; Nuñez-Peralta, Claudia ; Montesinos, Paula ; Webb, Susan M ; Valassi, Elena</creator><creatorcontrib>Martel-Duguech, Luciana ; Alonso-Pérez, Jorge ; Bascuñana, Helena ; Díaz-Manera, Jordi ; Llauger, Jaume ; Nuñez-Peralta, Claudia ; Montesinos, Paula ; Webb, Susan M ; Valassi, Elena</creatorcontrib><description>Introduction Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders. Objective To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction. Methods In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Results Intramuscular fat fraction was greater in patients than controls (P < 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (P < 0.05). The greater fat fraction in the combined anterior–posterior compartment and in each muscle was associated with worse performance on timed up and go (P < 0.05). The fat fraction in the anterior–posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (β = 0.737 P < 0.001). Conclusions Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-21-0209</identifier><identifier>PMID: 33950861</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Acromegaly ; Acromegaly - metabolism ; Acromegaly - physiopathology ; Adipose Tissue - metabolism ; Adult ; Case-Control Studies ; Clinical Study ; Cross-Sectional Studies ; Disease control ; Exercise - physiology ; Female ; Gait ; Hand Strength - physiology ; Humans ; Insulin-like growth factor I ; Lipid Metabolism ; Magnetic resonance imaging ; Male ; Middle Aged ; Muscle, Skeletal - physiopathology ; Muscles ; Muscles - metabolism ; Muscles - physiology ; Osteoarthritis</subject><ispartof>European journal of endocrinology, 2021-07, Vol.185 (1), p.167-177</ispartof><rights>European Society of Endocrinology</rights><rights>Copyright BioScientifica Ltd. Jul 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b396t-91520156a63778c0bcb40951613fdd2bedbfa08e39a1893dac6afb83fd4586853</citedby><orcidid>0000-0001-7052-6436 ; 0000-0002-3864-0105 ; 0000-0001-8866-5186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33950861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martel-Duguech, Luciana</creatorcontrib><creatorcontrib>Alonso-Pérez, Jorge</creatorcontrib><creatorcontrib>Bascuñana, Helena</creatorcontrib><creatorcontrib>Díaz-Manera, Jordi</creatorcontrib><creatorcontrib>Llauger, Jaume</creatorcontrib><creatorcontrib>Nuñez-Peralta, Claudia</creatorcontrib><creatorcontrib>Montesinos, Paula</creatorcontrib><creatorcontrib>Webb, Susan M</creatorcontrib><creatorcontrib>Valassi, Elena</creatorcontrib><title>Intramuscular fatty infiltration and physical function in controlled acromegaly</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Introduction Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders. Objective To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction. Methods In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Results Intramuscular fat fraction was greater in patients than controls (P < 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (P < 0.05). The greater fat fraction in the combined anterior–posterior compartment and in each muscle was associated with worse performance on timed up and go (P < 0.05). The fat fraction in the anterior–posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (β = 0.737 P < 0.001). Conclusions Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship.</description><subject>Acromegaly</subject><subject>Acromegaly - metabolism</subject><subject>Acromegaly - physiopathology</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Clinical Study</subject><subject>Cross-Sectional Studies</subject><subject>Disease control</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Gait</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Insulin-like growth factor I</subject><subject>Lipid Metabolism</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscles</subject><subject>Muscles - metabolism</subject><subject>Muscles - physiology</subject><subject>Osteoarthritis</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kL1PAyEcQInR2Fqd3M0lLibmlI-DcqNpqtY06aKJGwEOlIaDetwN_e-lVh0cnCA_Hi_wADhH8AZRAm_nT_MSoxJiWB-AMaqmdck4eT0EY8hhVVasIiNwktIaQpT38BiMCKkp5AyNwWoR-k62Q9KDl11hZd9vCxes83ncuxgKGZpi875NTktf2CHor6kLhY75avTeNIXUXWzNm_TbU3BkpU_m7HudgJf7-fPssVyuHhazu2WpSM36skYUQ0SZZGQ65RoqrSpYU8QQsU2DlWmUlZAbUkvEa9JIzaRVPB9WlDNOyQRc7b2bLn4MJvWidUkb72UwcUgCU4xZ1rEdevkHXcehC_l1maKEMp6NmbreU_krKXXGik3nWtltBYJi11nkzgIjseuc6Ytv56Ba0_yyP2EzgPaAcjFpZ0LvbC74r_QT_7aIaA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Martel-Duguech, Luciana</creator><creator>Alonso-Pérez, Jorge</creator><creator>Bascuñana, Helena</creator><creator>Díaz-Manera, Jordi</creator><creator>Llauger, Jaume</creator><creator>Nuñez-Peralta, Claudia</creator><creator>Montesinos, Paula</creator><creator>Webb, Susan M</creator><creator>Valassi, Elena</creator><general>Bioscientifica Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7052-6436</orcidid><orcidid>https://orcid.org/0000-0002-3864-0105</orcidid><orcidid>https://orcid.org/0000-0001-8866-5186</orcidid></search><sort><creationdate>20210701</creationdate><title>Intramuscular fatty infiltration and physical function in controlled acromegaly</title><author>Martel-Duguech, Luciana ; Alonso-Pérez, Jorge ; Bascuñana, Helena ; Díaz-Manera, Jordi ; Llauger, Jaume ; Nuñez-Peralta, Claudia ; Montesinos, Paula ; Webb, Susan M ; Valassi, Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b396t-91520156a63778c0bcb40951613fdd2bedbfa08e39a1893dac6afb83fd4586853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acromegaly</topic><topic>Acromegaly - metabolism</topic><topic>Acromegaly - physiopathology</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Clinical Study</topic><topic>Cross-Sectional Studies</topic><topic>Disease control</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Gait</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Insulin-like growth factor I</topic><topic>Lipid Metabolism</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscles</topic><topic>Muscles - metabolism</topic><topic>Muscles - physiology</topic><topic>Osteoarthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martel-Duguech, Luciana</creatorcontrib><creatorcontrib>Alonso-Pérez, Jorge</creatorcontrib><creatorcontrib>Bascuñana, Helena</creatorcontrib><creatorcontrib>Díaz-Manera, Jordi</creatorcontrib><creatorcontrib>Llauger, Jaume</creatorcontrib><creatorcontrib>Nuñez-Peralta, Claudia</creatorcontrib><creatorcontrib>Montesinos, Paula</creatorcontrib><creatorcontrib>Webb, Susan M</creatorcontrib><creatorcontrib>Valassi, Elena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martel-Duguech, Luciana</au><au>Alonso-Pérez, Jorge</au><au>Bascuñana, Helena</au><au>Díaz-Manera, Jordi</au><au>Llauger, Jaume</au><au>Nuñez-Peralta, Claudia</au><au>Montesinos, Paula</au><au>Webb, Susan M</au><au>Valassi, Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramuscular fatty infiltration and physical function in controlled acromegaly</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>185</volume><issue>1</issue><spage>167</spage><epage>177</epage><pages>167-177</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Introduction Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased i.m. fat fraction is a known cause of muscle dysfunction in several disorders. Objective To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients and its relationship with muscle dysfunction. Methods In a cross-sectional study, we included 36 patients with controlled acromegaly and 36 matched controls. We assessed the percentage of fat fraction in each thigh muscle, using MRI 2-point Dixon sequence, and muscle performance and strength using the gait speed, timed up and go, 30-s chair stand, and hand grip strength tests. We evaluated joint symptoms using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). Results Intramuscular fat fraction was greater in patients than controls (P < 0.05 for muscle compartments, rectus femoris (RF), vastus intermedius (VI), adductor magnus (AM) and semimembranosus). Patients had slower gait speed and poorer performance on the 30-s chair stand and timed up and go tests than controls (P < 0.05). The greater fat fraction in the combined anterior–posterior compartment and in each muscle was associated with worse performance on timed up and go (P < 0.05). The fat fraction in the anterior–posterior compartment predicted performance on timed up and go after adjusting for muscle area, IGF-I and WOMAC functional and pain scores (β = 0.737 P < 0.001). Conclusions Patients with controlled acromegaly have greater thigh i.m. fatty infiltration, which is associated with muscle dysfunction. Futures studies are needed to elucidate the mechanisms underlying this relationship.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>33950861</pmid><doi>10.1530/EJE-21-0209</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7052-6436</orcidid><orcidid>https://orcid.org/0000-0002-3864-0105</orcidid><orcidid>https://orcid.org/0000-0001-8866-5186</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0804-4643 |
| ispartof | European journal of endocrinology, 2021-07, Vol.185 (1), p.167-177 |
| issn | 0804-4643 1479-683X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2522616165 |
| source | Oxford Journals Online |
| subjects | Acromegaly Acromegaly - metabolism Acromegaly - physiopathology Adipose Tissue - metabolism Adult Case-Control Studies Clinical Study Cross-Sectional Studies Disease control Exercise - physiology Female Gait Hand Strength - physiology Humans Insulin-like growth factor I Lipid Metabolism Magnetic resonance imaging Male Middle Aged Muscle, Skeletal - physiopathology Muscles Muscles - metabolism Muscles - physiology Osteoarthritis |
| title | Intramuscular fatty infiltration and physical function in controlled acromegaly |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T02%3A24%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intramuscular%20fatty%20infiltration%20and%20physical%20function%20in%20controlled%20acromegaly&rft.jtitle=European%20journal%20of%20endocrinology&rft.au=Martel-Duguech,%20Luciana&rft.date=2021-07-01&rft.volume=185&rft.issue=1&rft.spage=167&rft.epage=177&rft.pages=167-177&rft.issn=0804-4643&rft.eissn=1479-683X&rft_id=info:doi/10.1530/EJE-21-0209&rft_dat=%3Cproquest_cross%3E2553568868%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b396t-91520156a63778c0bcb40951613fdd2bedbfa08e39a1893dac6afb83fd4586853%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2553568868&rft_id=info:pmid/33950861&rfr_iscdi=true |