Loading…
The paradoxical and still obscure properties of fungal extracellular vesicles
•Fungal extracellular vesicles (EVs) carry a number of virulence factors, virulence regulators and immunogens.•Innate immune response is activated by fungal EVs.•Fungal EVs can impact disease development in insect, plants and mammals.•Fungal organisms can use EVs to communicate to each other. Early...
Saved in:
Published in: | Molecular immunology 2021-07, Vol.135, p.137-146 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73 |
---|---|
cites | cdi_FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73 |
container_end_page | 146 |
container_issue | |
container_start_page | 137 |
container_title | Molecular immunology |
container_volume | 135 |
creator | Piffer, Alicia C. Kuczera, Diogo Rodrigues, Marcio L. Nimrichter, Leonardo |
description | •Fungal extracellular vesicles (EVs) carry a number of virulence factors, virulence regulators and immunogens.•Innate immune response is activated by fungal EVs.•Fungal EVs can impact disease development in insect, plants and mammals.•Fungal organisms can use EVs to communicate to each other.
Early compositional studies of fungal EVs revealed a complex combination of biomolecules, including proteins, lipids, glycans, polysaccharides, nucleic acid and pigments, indicating that these compartments could be involved with multiple functions. Curiously, some of the activities attributed to fungal EVs were already attested experimentally and are implicated with contrasting effects in vitro and in vivo. For instance, the presence of virulence factors is correlated with increased pathogenic potential. Indeed, the administration to hosts of EVs along with some fungal pathogens seems to help the disease development. However, it has been clearly shown that immunization of insects and mice with fungal EVs can protect these animals against a subsequent infection. Fungal EVs not only influence the host response, as concluded from the observation that these compartments also work as messengers between fungal organisms. In this context, despite their size characterization, other physical properties of EVs are poorly known. For instance, their stability and half-life under physiological conditions can be a crucial parameter determining their long-distance effects. In this review, we will discuss the paradoxical and still unexploited functions and properties of fungal EVs that could be determinant for their biological functions. |
doi_str_mv | 10.1016/j.molimm.2021.04.009 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2518741752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161589021001267</els_id><sourcerecordid>2518741752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78A5EevbRO2qRNL4KIX7DiZT2HJJ1olnS7Jq3ovzfLrh49ZSDPzLzzEHJOoaBA66tl0Q_e9X1RQkkLYAVAu0dmVDRl3lJW7pNZwmjORQtH5DjGJQDUUPNDclRVouW8ETPyvHjHbK2C6oYvZ5TP1KrL4ui8zwYdzRTSbxjWGEaHMRtsZqfVW8LwawzKoPeTVyH7xOiMx3hKDqzyEc927wl5vb9b3D7m85eHp9ubeW6quhxzrZrKUgvU6JppC3UqbCO46Db5DINOtFZXSolagBJV1SLVoBm3gnGNTXVCLrdzU7aPCeMoexc3adQKhynKkicNjDa8TCjboiYMMQa0ch1cr8K3pCA3IuVSbkXKjUgJTCaRqe1it2HSPXZ_Tb_mEnC9BTDd-ekwyGgcrgx2LqAZZTe4_zf8AJiIhyo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2518741752</pqid></control><display><type>article</type><title>The paradoxical and still obscure properties of fungal extracellular vesicles</title><source>ScienceDirect Journals</source><creator>Piffer, Alicia C. ; Kuczera, Diogo ; Rodrigues, Marcio L. ; Nimrichter, Leonardo</creator><creatorcontrib>Piffer, Alicia C. ; Kuczera, Diogo ; Rodrigues, Marcio L. ; Nimrichter, Leonardo</creatorcontrib><description>•Fungal extracellular vesicles (EVs) carry a number of virulence factors, virulence regulators and immunogens.•Innate immune response is activated by fungal EVs.•Fungal EVs can impact disease development in insect, plants and mammals.•Fungal organisms can use EVs to communicate to each other.
Early compositional studies of fungal EVs revealed a complex combination of biomolecules, including proteins, lipids, glycans, polysaccharides, nucleic acid and pigments, indicating that these compartments could be involved with multiple functions. Curiously, some of the activities attributed to fungal EVs were already attested experimentally and are implicated with contrasting effects in vitro and in vivo. For instance, the presence of virulence factors is correlated with increased pathogenic potential. Indeed, the administration to hosts of EVs along with some fungal pathogens seems to help the disease development. However, it has been clearly shown that immunization of insects and mice with fungal EVs can protect these animals against a subsequent infection. Fungal EVs not only influence the host response, as concluded from the observation that these compartments also work as messengers between fungal organisms. In this context, despite their size characterization, other physical properties of EVs are poorly known. For instance, their stability and half-life under physiological conditions can be a crucial parameter determining their long-distance effects. In this review, we will discuss the paradoxical and still unexploited functions and properties of fungal EVs that could be determinant for their biological functions.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2021.04.009</identifier><identifier>PMID: 33895578</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>EVs stability ; Fungal extracellular vesicles ; Innate immune response ; Vaccine</subject><ispartof>Molecular immunology, 2021-07, Vol.135, p.137-146</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73</citedby><cites>FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33895578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piffer, Alicia C.</creatorcontrib><creatorcontrib>Kuczera, Diogo</creatorcontrib><creatorcontrib>Rodrigues, Marcio L.</creatorcontrib><creatorcontrib>Nimrichter, Leonardo</creatorcontrib><title>The paradoxical and still obscure properties of fungal extracellular vesicles</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>•Fungal extracellular vesicles (EVs) carry a number of virulence factors, virulence regulators and immunogens.•Innate immune response is activated by fungal EVs.•Fungal EVs can impact disease development in insect, plants and mammals.•Fungal organisms can use EVs to communicate to each other.
Early compositional studies of fungal EVs revealed a complex combination of biomolecules, including proteins, lipids, glycans, polysaccharides, nucleic acid and pigments, indicating that these compartments could be involved with multiple functions. Curiously, some of the activities attributed to fungal EVs were already attested experimentally and are implicated with contrasting effects in vitro and in vivo. For instance, the presence of virulence factors is correlated with increased pathogenic potential. Indeed, the administration to hosts of EVs along with some fungal pathogens seems to help the disease development. However, it has been clearly shown that immunization of insects and mice with fungal EVs can protect these animals against a subsequent infection. Fungal EVs not only influence the host response, as concluded from the observation that these compartments also work as messengers between fungal organisms. In this context, despite their size characterization, other physical properties of EVs are poorly known. For instance, their stability and half-life under physiological conditions can be a crucial parameter determining their long-distance effects. In this review, we will discuss the paradoxical and still unexploited functions and properties of fungal EVs that could be determinant for their biological functions.</description><subject>EVs stability</subject><subject>Fungal extracellular vesicles</subject><subject>Innate immune response</subject><subject>Vaccine</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMoun78A5EevbRO2qRNL4KIX7DiZT2HJJ1olnS7Jq3ovzfLrh49ZSDPzLzzEHJOoaBA66tl0Q_e9X1RQkkLYAVAu0dmVDRl3lJW7pNZwmjORQtH5DjGJQDUUPNDclRVouW8ETPyvHjHbK2C6oYvZ5TP1KrL4ui8zwYdzRTSbxjWGEaHMRtsZqfVW8LwawzKoPeTVyH7xOiMx3hKDqzyEc927wl5vb9b3D7m85eHp9ubeW6quhxzrZrKUgvU6JppC3UqbCO46Db5DINOtFZXSolagBJV1SLVoBm3gnGNTXVCLrdzU7aPCeMoexc3adQKhynKkicNjDa8TCjboiYMMQa0ch1cr8K3pCA3IuVSbkXKjUgJTCaRqe1it2HSPXZ_Tb_mEnC9BTDd-ekwyGgcrgx2LqAZZTe4_zf8AJiIhyo</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Piffer, Alicia C.</creator><creator>Kuczera, Diogo</creator><creator>Rodrigues, Marcio L.</creator><creator>Nimrichter, Leonardo</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210701</creationdate><title>The paradoxical and still obscure properties of fungal extracellular vesicles</title><author>Piffer, Alicia C. ; Kuczera, Diogo ; Rodrigues, Marcio L. ; Nimrichter, Leonardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>EVs stability</topic><topic>Fungal extracellular vesicles</topic><topic>Innate immune response</topic><topic>Vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piffer, Alicia C.</creatorcontrib><creatorcontrib>Kuczera, Diogo</creatorcontrib><creatorcontrib>Rodrigues, Marcio L.</creatorcontrib><creatorcontrib>Nimrichter, Leonardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piffer, Alicia C.</au><au>Kuczera, Diogo</au><au>Rodrigues, Marcio L.</au><au>Nimrichter, Leonardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The paradoxical and still obscure properties of fungal extracellular vesicles</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>135</volume><spage>137</spage><epage>146</epage><pages>137-146</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>•Fungal extracellular vesicles (EVs) carry a number of virulence factors, virulence regulators and immunogens.•Innate immune response is activated by fungal EVs.•Fungal EVs can impact disease development in insect, plants and mammals.•Fungal organisms can use EVs to communicate to each other.
Early compositional studies of fungal EVs revealed a complex combination of biomolecules, including proteins, lipids, glycans, polysaccharides, nucleic acid and pigments, indicating that these compartments could be involved with multiple functions. Curiously, some of the activities attributed to fungal EVs were already attested experimentally and are implicated with contrasting effects in vitro and in vivo. For instance, the presence of virulence factors is correlated with increased pathogenic potential. Indeed, the administration to hosts of EVs along with some fungal pathogens seems to help the disease development. However, it has been clearly shown that immunization of insects and mice with fungal EVs can protect these animals against a subsequent infection. Fungal EVs not only influence the host response, as concluded from the observation that these compartments also work as messengers between fungal organisms. In this context, despite their size characterization, other physical properties of EVs are poorly known. For instance, their stability and half-life under physiological conditions can be a crucial parameter determining their long-distance effects. In this review, we will discuss the paradoxical and still unexploited functions and properties of fungal EVs that could be determinant for their biological functions.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33895578</pmid><doi>10.1016/j.molimm.2021.04.009</doi><tpages>10</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0161-5890 |
ispartof | Molecular immunology, 2021-07, Vol.135, p.137-146 |
issn | 0161-5890 1872-9142 |
language | eng |
recordid | cdi_proquest_miscellaneous_2518741752 |
source | ScienceDirect Journals |
subjects | EVs stability Fungal extracellular vesicles Innate immune response Vaccine |
title | The paradoxical and still obscure properties of fungal extracellular vesicles |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A30%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20paradoxical%20and%20still%20obscure%20properties%20of%20fungal%20extracellular%20vesicles&rft.jtitle=Molecular%20immunology&rft.au=Piffer,%20Alicia%20C.&rft.date=2021-07-01&rft.volume=135&rft.spage=137&rft.epage=146&rft.pages=137-146&rft.issn=0161-5890&rft.eissn=1872-9142&rft_id=info:doi/10.1016/j.molimm.2021.04.009&rft_dat=%3Cproquest_cross%3E2518741752%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c362t-ba73f1f01cb64bf061cbf7858d6065c40d89fb3aa8680a8339e1b0b45f845be73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2518741752&rft_id=info:pmid/33895578&rfr_iscdi=true |