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Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures
Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of assisted reproductive technology (ART) programme success. The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion m...
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| Published in: | Zygote (Cambridge) 2021-10, Vol.29 (5), p.365-371 |
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| creator | Benkhalifa, Mustapha Zidi, Wiem Bahri, Hatem Mahjoub, Sami Boudhraa, Khaled Sanhaji, Haifa Khorsi-Cauet, Hafida Feki, Moncef Benkhalifa, Moncef Allal-Elasmi, Monia |
| description | Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of assisted reproductive technology (ART) programme success. The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged between 25 and 39 years old and undergoing intracytoplasmic sperm injection (ICSI). These women were divided into two groups: 22 RIF women with embryo implantation failures after the transfer of at least four fresh or frozen-thawed good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women (controls) who achieved a clinical pregnancy at their first ICSI attempt. The PB and FF samples were obtained from each patient on the day of oocyte retrieval. MMP-1, -2, -3, -7, -9, TIMP-1, -2, vascular endothelial growth factor (VEGF), leukaemia inhibitory factor (LIF), vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecules 1 (ICAM1) were analyzed using enzyme-linked immunosorbent assay of PB and FF. Our results showed significant decreases in PB MMP-7 and PB VEGF in the RIF group compared with controls [281.11 (33-614) pg/ml vs 119.92 (27-441) pg/ml; P-value = 0.030] and [82.54 (25.94-210.20) pg/ml vs 30.93 (13.62-193.33) pg/ml; P-value = 0.022; respectively]. Receiver operating characteristic (ROC) curve analysis showed informative area under the curve values for PB MMP-7, as well as for PB VEGF, making them able to be proposed as biomarkers of the RIF. Therefore, circulating MMP-7 and VEGF seem to play an interesting role in embryo implantation in in vitro fertilization (IVF)/ICSI cycles and could be proposed as circulating biomarkers of the RIF. These results could be helpful for clinicians and patients to choose the best rescue strategy and treatment to minimize implantation failure in women undergoing IVF/ICSI procedures after the first attempt. |
| doi_str_mv | 10.1017/S0967199421000113 |
| format | article |
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The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged between 25 and 39 years old and undergoing intracytoplasmic sperm injection (ICSI). These women were divided into two groups: 22 RIF women with embryo implantation failures after the transfer of at least four fresh or frozen-thawed good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women (controls) who achieved a clinical pregnancy at their first ICSI attempt. The PB and FF samples were obtained from each patient on the day of oocyte retrieval. MMP-1, -2, -3, -7, -9, TIMP-1, -2, vascular endothelial growth factor (VEGF), leukaemia inhibitory factor (LIF), vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecules 1 (ICAM1) were analyzed using enzyme-linked immunosorbent assay of PB and FF. Our results showed significant decreases in PB MMP-7 and PB VEGF in the RIF group compared with controls [281.11 (33-614) pg/ml vs 119.92 (27-441) pg/ml; P-value = 0.030] and [82.54 (25.94-210.20) pg/ml vs 30.93 (13.62-193.33) pg/ml; P-value = 0.022; respectively]. Receiver operating characteristic (ROC) curve analysis showed informative area under the curve values for PB MMP-7, as well as for PB VEGF, making them able to be proposed as biomarkers of the RIF. Therefore, circulating MMP-7 and VEGF seem to play an interesting role in embryo implantation in in vitro fertilization (IVF)/ICSI cycles and could be proposed as circulating biomarkers of the RIF. These results could be helpful for clinicians and patients to choose the best rescue strategy and treatment to minimize implantation failure in women undergoing IVF/ICSI procedures after the first attempt.</description><identifier>ISSN: 0967-1994</identifier><identifier>EISSN: 1469-8730</identifier><identifier>DOI: 10.1017/S0967199421000113</identifier><identifier>PMID: 33736747</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adhesion ; Adult ; Biomarkers ; Cell adhesion ; Cell adhesion & migration ; Cell adhesion molecules ; Cytokines ; Embryo Implantation ; Embryos ; Endometrium ; Enzyme-linked immunosorbent assay ; Female ; Fertilization in Vitro ; Follicular fluid ; Gametocytes ; Growth factors ; Humans ; Implantation ; In vitro fertilization ; Infertility ; Intercellular adhesion molecule 1 ; Interstitial collagenase ; Investigations ; Leukemia ; Leukemia inhibitory factor ; Matrilysin ; Matrix metalloproteinase ; Matrix Metalloproteinase 7 ; Matrix metalloproteinases ; Ovaries ; Patients ; Peripheral blood ; Plasma ; Pregnancy ; Pregnancy Rate ; Reproductive technologies ; Reproductive technology ; Sperm ; Sperm Injections, Intracytoplasmic ; Statistical analysis ; Tissue inhibitor of metalloproteinase 1 ; Vascular cell adhesion molecule 1 ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A</subject><ispartof>Zygote (Cambridge), 2021-10, Vol.29 (5), p.365-371</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-84c7113f0b015d8ab21a4d849619f08d42501b8a8b4e506096850e80fe5b76263</citedby><cites>FETCH-LOGICAL-c329t-84c7113f0b015d8ab21a4d849619f08d42501b8a8b4e506096850e80fe5b76263</cites><orcidid>0000-0002-5325-6347 ; 0000-0002-3382-989X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33736747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benkhalifa, Mustapha</creatorcontrib><creatorcontrib>Zidi, Wiem</creatorcontrib><creatorcontrib>Bahri, Hatem</creatorcontrib><creatorcontrib>Mahjoub, Sami</creatorcontrib><creatorcontrib>Boudhraa, Khaled</creatorcontrib><creatorcontrib>Sanhaji, Haifa</creatorcontrib><creatorcontrib>Khorsi-Cauet, Hafida</creatorcontrib><creatorcontrib>Feki, Moncef</creatorcontrib><creatorcontrib>Benkhalifa, Moncef</creatorcontrib><creatorcontrib>Allal-Elasmi, Monia</creatorcontrib><title>Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures</title><title>Zygote (Cambridge)</title><addtitle>Zygote</addtitle><description>Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of assisted reproductive technology (ART) programme success. The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged between 25 and 39 years old and undergoing intracytoplasmic sperm injection (ICSI). These women were divided into two groups: 22 RIF women with embryo implantation failures after the transfer of at least four fresh or frozen-thawed good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women (controls) who achieved a clinical pregnancy at their first ICSI attempt. The PB and FF samples were obtained from each patient on the day of oocyte retrieval. MMP-1, -2, -3, -7, -9, TIMP-1, -2, vascular endothelial growth factor (VEGF), leukaemia inhibitory factor (LIF), vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecules 1 (ICAM1) were analyzed using enzyme-linked immunosorbent assay of PB and FF. Our results showed significant decreases in PB MMP-7 and PB VEGF in the RIF group compared with controls [281.11 (33-614) pg/ml vs 119.92 (27-441) pg/ml; P-value = 0.030] and [82.54 (25.94-210.20) pg/ml vs 30.93 (13.62-193.33) pg/ml; P-value = 0.022; respectively]. Receiver operating characteristic (ROC) curve analysis showed informative area under the curve values for PB MMP-7, as well as for PB VEGF, making them able to be proposed as biomarkers of the RIF. Therefore, circulating MMP-7 and VEGF seem to play an interesting role in embryo implantation in in vitro fertilization (IVF)/ICSI cycles and could be proposed as circulating biomarkers of the RIF. These results could be helpful for clinicians and patients to choose the best rescue strategy and treatment to minimize implantation failure in women undergoing IVF/ICSI procedures after the first attempt.</description><subject>Adhesion</subject><subject>Adult</subject><subject>Biomarkers</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Cytokines</subject><subject>Embryo Implantation</subject><subject>Embryos</subject><subject>Endometrium</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Follicular fluid</subject><subject>Gametocytes</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Implantation</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interstitial collagenase</subject><subject>Investigations</subject><subject>Leukemia</subject><subject>Leukemia inhibitory factor</subject><subject>Matrilysin</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 7</subject><subject>Matrix metalloproteinases</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive technologies</subject><subject>Reproductive technology</subject><subject>Sperm</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Statistical analysis</subject><subject>Tissue inhibitor of metalloproteinase 1</subject><subject>Vascular cell adhesion molecule 1</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor 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MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures</title><author>Benkhalifa, Mustapha ; Zidi, Wiem ; Bahri, Hatem ; Mahjoub, Sami ; Boudhraa, Khaled ; Sanhaji, Haifa ; Khorsi-Cauet, Hafida ; Feki, Moncef ; Benkhalifa, Moncef ; Allal-Elasmi, Monia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-84c7113f0b015d8ab21a4d849619f08d42501b8a8b4e506096850e80fe5b76263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adhesion</topic><topic>Adult</topic><topic>Biomarkers</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Cytokines</topic><topic>Embryo Implantation</topic><topic>Embryos</topic><topic>Endometrium</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Follicular fluid</topic><topic>Gametocytes</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Implantation</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interstitial collagenase</topic><topic>Investigations</topic><topic>Leukemia</topic><topic>Leukemia inhibitory factor</topic><topic>Matrilysin</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 7</topic><topic>Matrix metalloproteinases</topic><topic>Ovaries</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive technologies</topic><topic>Reproductive technology</topic><topic>Sperm</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Statistical analysis</topic><topic>Tissue inhibitor of metalloproteinase 1</topic><topic>Vascular cell adhesion molecule 1</topic><topic>Vascular endothelial growth 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benkhalifa, Mustapha</au><au>Zidi, Wiem</au><au>Bahri, Hatem</au><au>Mahjoub, Sami</au><au>Boudhraa, Khaled</au><au>Sanhaji, Haifa</au><au>Khorsi-Cauet, Hafida</au><au>Feki, Moncef</au><au>Benkhalifa, Moncef</au><au>Allal-Elasmi, Monia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures</atitle><jtitle>Zygote (Cambridge)</jtitle><addtitle>Zygote</addtitle><date>2021-10</date><risdate>2021</risdate><volume>29</volume><issue>5</issue><spage>365</spage><epage>371</epage><pages>365-371</pages><issn>0967-1994</issn><eissn>1469-8730</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of assisted reproductive technology (ART) programme success. The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged between 25 and 39 years old and undergoing intracytoplasmic sperm injection (ICSI). These women were divided into two groups: 22 RIF women with embryo implantation failures after the transfer of at least four fresh or frozen-thawed good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women (controls) who achieved a clinical pregnancy at their first ICSI attempt. The PB and FF samples were obtained from each patient on the day of oocyte retrieval. MMP-1, -2, -3, -7, -9, TIMP-1, -2, vascular endothelial growth factor (VEGF), leukaemia inhibitory factor (LIF), vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecules 1 (ICAM1) were analyzed using enzyme-linked immunosorbent assay of PB and FF. Our results showed significant decreases in PB MMP-7 and PB VEGF in the RIF group compared with controls [281.11 (33-614) pg/ml vs 119.92 (27-441) pg/ml; P-value = 0.030] and [82.54 (25.94-210.20) pg/ml vs 30.93 (13.62-193.33) pg/ml; P-value = 0.022; respectively]. Receiver operating characteristic (ROC) curve analysis showed informative area under the curve values for PB MMP-7, as well as for PB VEGF, making them able to be proposed as biomarkers of the RIF. Therefore, circulating MMP-7 and VEGF seem to play an interesting role in embryo implantation in in vitro fertilization (IVF)/ICSI cycles and could be proposed as circulating biomarkers of the RIF. These results could be helpful for clinicians and patients to choose the best rescue strategy and treatment to minimize implantation failure in women undergoing IVF/ICSI procedures after the first attempt.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>33736747</pmid><doi>10.1017/S0967199421000113</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5325-6347</orcidid><orcidid>https://orcid.org/0000-0002-3382-989X</orcidid></addata></record> |
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| ispartof | Zygote (Cambridge), 2021-10, Vol.29 (5), p.365-371 |
| issn | 0967-1994 1469-8730 |
| language | eng |
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| source | Cambridge Journals Online |
| subjects | Adhesion Adult Biomarkers Cell adhesion Cell adhesion & migration Cell adhesion molecules Cytokines Embryo Implantation Embryos Endometrium Enzyme-linked immunosorbent assay Female Fertilization in Vitro Follicular fluid Gametocytes Growth factors Humans Implantation In vitro fertilization Infertility Intercellular adhesion molecule 1 Interstitial collagenase Investigations Leukemia Leukemia inhibitory factor Matrilysin Matrix metalloproteinase Matrix Metalloproteinase 7 Matrix metalloproteinases Ovaries Patients Peripheral blood Plasma Pregnancy Pregnancy Rate Reproductive technologies Reproductive technology Sperm Sperm Injections, Intracytoplasmic Statistical analysis Tissue inhibitor of metalloproteinase 1 Vascular cell adhesion molecule 1 Vascular endothelial growth factor Vascular Endothelial Growth Factor A |
| title | Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures |
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