Cancer and Cardiovascular Risk in Women With Hypertensive Disorders of Pregnancy Carrying a Common IGF1R Variant

To evaluate the impact of insulin-like growth factor 1 receptor variant rs2016347 on the risk for breast and nonbreast cancers and cardiovascular disease in women with a history of hypertensive disorders of pregnancy (HDP). This retrospective cohort study included all parous women in the UK Biobank...

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Published in:Mayo Clinic proceedings 2020-12, Vol.95 (12), p.2684-2696
Main Authors: Powell, Mark J., Dufault, Suzanne M., Gunderson, Erica P., Benz, Christopher C.
Format: Article
Language:English
Subjects:
Adult
Age
Alleles
Biobanks
Blood pressure
Blood Pressure Determination - statistics & numerical data
Breast cancer
Cardiovascular disease
Cardiovascular diseases
Cohort Studies
Female
Genotype & phenotype
Genotypes
Genotyping
Guanine
Haplotypes
Heart Disease Risk Factors
Humans
Hypertension
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - epidemiology
Hypertension, Pregnancy-Induced - genetics
Insulin
Insulin-like growth factors
Mortality
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - genetics
Polymorphism, Single Nucleotide
Population
Preeclampsia
Pregnancy
Pregnancy Complications, Cardiovascular - diagnosis
Pregnancy Complications, Cardiovascular - epidemiology
Pregnancy Complications, Cardiovascular - genetics
Receptor, IGF Type 1 - genetics
Retrospective Studies
Risk Assessment - methods
Thymine
United Kingdom - epidemiology
Womens health
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description To evaluate the impact of insulin-like growth factor 1 receptor variant rs2016347 on the risk for breast and nonbreast cancers and cardiovascular disease in women with a history of hypertensive disorders of pregnancy (HDP). This retrospective cohort study included all parous women in the UK Biobank with prior rs2016347 genotyping (N=204,155), with enrollment taking place from March 2006 to July 2010. History of HDP was self-reported, and outcomes included breast and all nonbreast cancers, hospital diagnoses of hypertension and cardiovascular disease, and direct blood pressure measurements. Women with previous HDP had a higher risk for future hypertension and cardiovascular diagnoses, increased blood pressures, and lower risk for breast cancer compared with women without HDP, consistent with prior studies. Hazard ratios for all nonbreast cancers were unchanged. However, when taking genotype into account, HDP-positive women carrying at least 1 thymine (T) allele of rs2016347 had a lower risk for nonbreast cancer (hazard ratio, 0.59; 95% CI, 0.37 to 0.92; P=.02) and lower systolic blood pressure (−2.08±0.98 mm Hg; P=.03) compared with women with the guanine/guanine (GG) genotype with positive evidence of interaction (HDP:T allele) for both outcomes; P=.04 and P=.03, respectively. Women who experience HDP and carry a T allele of rs2016347 have 41% lower risk for developing nonbreast cancer and a lower systolic blood pressure of 2.08 mm Hg when compared with those with the GG genotype, suggesting a possible role of the insulin-like growth factor 1 axis for both cardiovascular and cancer risk in women with HDP.
doi_str_mv 10.1016/j.mayocp.2020.03.037
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However, when taking genotype into account, HDP-positive women carrying at least 1 thymine (T) allele of rs2016347 had a lower risk for nonbreast cancer (hazard ratio, 0.59; 95% CI, 0.37 to 0.92; P=.02) and lower systolic blood pressure (−2.08±0.98 mm Hg; P=.03) compared with women with the guanine/guanine (GG) genotype with positive evidence of interaction (HDP:T allele) for both outcomes; P=.04 and P=.03, respectively. 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ispartof Mayo Clinic proceedings, 2020-12, Vol.95 (12), p.2684-2696
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source ScienceDirect®
subjects Adult
Age
Alleles
Biobanks
Blood pressure
Blood Pressure Determination - statistics & numerical data
Breast cancer
Cardiovascular disease
Cardiovascular diseases
Cohort Studies
Female
Genotype & phenotype
Genotypes
Genotyping
Guanine
Haplotypes
Heart Disease Risk Factors
Humans
Hypertension
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - epidemiology
Hypertension, Pregnancy-Induced - genetics
Insulin
Insulin-like growth factors
Mortality
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - genetics
Polymorphism, Single Nucleotide
Population
Preeclampsia
Pregnancy
Pregnancy Complications, Cardiovascular - diagnosis
Pregnancy Complications, Cardiovascular - epidemiology
Pregnancy Complications, Cardiovascular - genetics
Receptor, IGF Type 1 - genetics
Retrospective Studies
Risk Assessment - methods
Thymine
United Kingdom - epidemiology
Womens health
title Cancer and Cardiovascular Risk in Women With Hypertensive Disorders of Pregnancy Carrying a Common IGF1R Variant
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