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Calcium phosphate cement reinforced with poly (vinyl alcohol) fibers: An experimental and numerical failure analysis
Calcium phosphate cements (CPCs) have been widely used during the past decades as biocompatible bone substitution in maxillofacial, oral and orthopedic surgery. CPCs are injectable and are chemically resemblant to the mineral phase of native bone. Nevertheless, their low fracture toughness and high...
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| Published in: | Acta biomaterialia 2021-01, Vol.119, p.458-471 |
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| container_title | Acta biomaterialia |
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| creator | Paknahad, Ali Goudarzi, Mohsen Kucko, Nathan W. Leeuwenburgh, Sander C.G. Sluys, Lambertus J. |
| description | Calcium phosphate cements (CPCs) have been widely used during the past decades as biocompatible bone substitution in maxillofacial, oral and orthopedic surgery. CPCs are injectable and are chemically resemblant to the mineral phase of native bone. Nevertheless, their low fracture toughness and high brittleness reduce their clinical applicability to weakly loaded bones. Reinforcement of CPC matrix with polymeric fibers can overcome these mechanical drawbacks and significantly enhance their toughness and strength. Such fiber-reinforced calcium phosphate cements (FRCPCs) have the potential to act as advanced bone substitute in load-bearing anatomical sites. This work achieves integrated experimental and numerical characterization of the mechanical properties of FRCPCs under bending and tensile loading. To this end, a 3-D numerical gradient enhanced damage model combined with a dimensionally-reduced fiber model are employed to develop a computational model for material characterization and to simulate the failure process of fiber-reinforced CPC matrix based on experimental data. In addition, an advanced interfacial constitutive law, derived from micromechanical pull-out tests, is used to represent the interaction between the polymeric fiber and CPC matrix. The presented computational model is successfully validated with the experimental results and offers a firm basis for further investigations on the development of numerical and experimental analysis of fiber-reinforced bone cements. |
| doi_str_mv | 10.1016/j.actbio.2020.10.014 |
| format | article |
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CPCs are injectable and are chemically resemblant to the mineral phase of native bone. Nevertheless, their low fracture toughness and high brittleness reduce their clinical applicability to weakly loaded bones. Reinforcement of CPC matrix with polymeric fibers can overcome these mechanical drawbacks and significantly enhance their toughness and strength. Such fiber-reinforced calcium phosphate cements (FRCPCs) have the potential to act as advanced bone substitute in load-bearing anatomical sites. This work achieves integrated experimental and numerical characterization of the mechanical properties of FRCPCs under bending and tensile loading. To this end, a 3-D numerical gradient enhanced damage model combined with a dimensionally-reduced fiber model are employed to develop a computational model for material characterization and to simulate the failure process of fiber-reinforced CPC matrix based on experimental data. In addition, an advanced interfacial constitutive law, derived from micromechanical pull-out tests, is used to represent the interaction between the polymeric fiber and CPC matrix. The presented computational model is successfully validated with the experimental results and offers a firm basis for further investigations on the development of numerical and experimental analysis of fiber-reinforced bone cements.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2020.10.014</identifier><identifier>PMID: 33164819</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biocompatibility ; Biomedical materials ; Bone Cements ; Bone Substitutes ; Bone surgery ; Calcium ; Calcium Phosphates ; Cement reinforcements ; Computer applications ; Damage assessment ; Failure analysis ; Fiber reinforced materials ; Fiber-reinforced calcium phosphate cements ; Fibers ; Fracture toughness ; Loading ; Materials Testing ; Mathematical models ; Maxillofacial ; Mechanical properties ; Numerical modeling ; Orthopedics ; Polyvinyl Alcohol ; Pull out tests ; Substitute bone ; Surgical implants ; Tensile test ; Three dimensional models ; Three-point bending test</subject><ispartof>Acta biomaterialia, 2021-01, Vol.119, p.458-471</ispartof><rights>2020 Acta Materialia Inc.</rights><rights>Copyright © 2020 Acta Materialia Inc. 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CPCs are injectable and are chemically resemblant to the mineral phase of native bone. Nevertheless, their low fracture toughness and high brittleness reduce their clinical applicability to weakly loaded bones. Reinforcement of CPC matrix with polymeric fibers can overcome these mechanical drawbacks and significantly enhance their toughness and strength. Such fiber-reinforced calcium phosphate cements (FRCPCs) have the potential to act as advanced bone substitute in load-bearing anatomical sites. This work achieves integrated experimental and numerical characterization of the mechanical properties of FRCPCs under bending and tensile loading. To this end, a 3-D numerical gradient enhanced damage model combined with a dimensionally-reduced fiber model are employed to develop a computational model for material characterization and to simulate the failure process of fiber-reinforced CPC matrix based on experimental data. In addition, an advanced interfacial constitutive law, derived from micromechanical pull-out tests, is used to represent the interaction between the polymeric fiber and CPC matrix. The presented computational model is successfully validated with the experimental results and offers a firm basis for further investigations on the development of numerical and experimental analysis of fiber-reinforced bone cements.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone Cements</subject><subject>Bone Substitutes</subject><subject>Bone surgery</subject><subject>Calcium</subject><subject>Calcium Phosphates</subject><subject>Cement reinforcements</subject><subject>Computer applications</subject><subject>Damage assessment</subject><subject>Failure analysis</subject><subject>Fiber reinforced materials</subject><subject>Fiber-reinforced calcium phosphate cements</subject><subject>Fibers</subject><subject>Fracture toughness</subject><subject>Loading</subject><subject>Materials Testing</subject><subject>Mathematical models</subject><subject>Maxillofacial</subject><subject>Mechanical properties</subject><subject>Numerical modeling</subject><subject>Orthopedics</subject><subject>Polyvinyl Alcohol</subject><subject>Pull out tests</subject><subject>Substitute bone</subject><subject>Surgical implants</subject><subject>Tensile test</subject><subject>Three dimensional models</subject><subject>Three-point bending test</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU2P1SAYhYnROOPoPzCGxM246JWvAnVhMrkZP5JJ3OiaUPqSyw0tFdrR---H5o4uXLgCTp7zAucg9JqSHSVUvj_urFv6kHaMsE3aESqeoEuqlW5UK_XTuleCNYpIeoFelHIkhGvK9HN0wTmVQtPuEi17G11YRzwfUpkPdgHsYIRpwRnC5FN2MOBfYTngOcUTvr4P0yni6kmHFN9hH3rI5QO-mTD8niGHzWorMA14WscquHryNsQ1Q1VtPJVQXqJn3sYCrx7XK_Tj0-33_Zfm7tvnr_ubu8YJLpfGK-ck1xoUt7QlBIRyXnaD71vPubOsZb3yHe2gY8Ky3pOhVy3wjosOuG75Fbo-z51z-rlCWcwYioMY7QRpLYaJVneSECUq-vYf9JjWXN-7UVpq2dZcKyXOlMuplAzezPXLNp8MJWZrxRzNuRWztbKptZVqe_M4fO1HGP6a_tRQgY9nAGoa9wGyKS7AVLMPGdxihhT-f8MDlsmgiw</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Paknahad, Ali</creator><creator>Goudarzi, Mohsen</creator><creator>Kucko, Nathan W.</creator><creator>Leeuwenburgh, Sander C.G.</creator><creator>Sluys, Lambertus J.</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4904-8238</orcidid></search><sort><creationdate>20210101</creationdate><title>Calcium phosphate cement reinforced with poly (vinyl alcohol) fibers: An experimental and numerical failure analysis</title><author>Paknahad, Ali ; 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In addition, an advanced interfacial constitutive law, derived from micromechanical pull-out tests, is used to represent the interaction between the polymeric fiber and CPC matrix. The presented computational model is successfully validated with the experimental results and offers a firm basis for further investigations on the development of numerical and experimental analysis of fiber-reinforced bone cements.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33164819</pmid><doi>10.1016/j.actbio.2020.10.014</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-4904-8238</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta biomaterialia, 2021-01, Vol.119, p.458-471 |
| issn | 1742-7061 1878-7568 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Biocompatibility Biomedical materials Bone Cements Bone Substitutes Bone surgery Calcium Calcium Phosphates Cement reinforcements Computer applications Damage assessment Failure analysis Fiber reinforced materials Fiber-reinforced calcium phosphate cements Fibers Fracture toughness Loading Materials Testing Mathematical models Maxillofacial Mechanical properties Numerical modeling Orthopedics Polyvinyl Alcohol Pull out tests Substitute bone Surgical implants Tensile test Three dimensional models Three-point bending test |
| title | Calcium phosphate cement reinforced with poly (vinyl alcohol) fibers: An experimental and numerical failure analysis |
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