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Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus
Dromedary camel hepatitis E virus is a novel HEV that belongs to the family Hepeviridae, and is classified as genotype 7 HEV (HEV-7). Since HEV-7 is transmitted from camels to humans and causes acute hepatitis E, this virus is a non-negligible pathogen for zoonosis, and a vaccine against HEV-7 infec...
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| Published in: | Vaccine 2020-10, Vol.38 (46), p.7316-7322 |
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| container_end_page | 7322 |
| container_issue | 46 |
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| container_title | Vaccine |
| container_volume | 38 |
| creator | Guo, Yingqiu Yang, Fengmei Xu, Xingli Feng, Min Liao, Yun He, Zhanlong Takeda, Naokazu Muramatsu, Masamichi Li, Qihan Li, Tian-Cheng |
| description | Dromedary camel hepatitis E virus is a novel HEV that belongs to the family Hepeviridae, and is classified as genotype 7 HEV (HEV-7). Since HEV-7 is transmitted from camels to humans and causes acute hepatitis E, this virus is a non-negligible pathogen for zoonosis, and a vaccine against HEV-7 infection is urgently needed. Here, we first intravenously inoculated HEV-7 to rhesus monkeys to explore the susceptibility, and we established an animal model. We then used virus-like particles (VLPs) of HEV-1 (HEV-1 VLPs) and HEV-3 (HEV-3 VLPs), a candidate hepatitis E vaccine, to intramuscularly inoculate rhesus monkeys. The monkeys elicited IgG antibody titers as high as >1:102,400 against heterologous HEV-7 without any adjuvants. The HEV-1 VLPs and HEV-3 VLPs-immunized monkeys were challenged intravenously with HEV-7, and they were protected completely from the infection, demonstrating that these VLPs could be a usable vaccine against HEV-7 infection. We also observed that HEV-7-infected rhesus monkeys did not show any liver damage during these experiments. Further efforts are necessary to establish an animal model for investigation of the pathogenesis of hepatitis E caused by HEV-7 infection. |
| doi_str_mv | 10.1016/j.vaccine.2020.09.036 |
| format | article |
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Since HEV-7 is transmitted from camels to humans and causes acute hepatitis E, this virus is a non-negligible pathogen for zoonosis, and a vaccine against HEV-7 infection is urgently needed. Here, we first intravenously inoculated HEV-7 to rhesus monkeys to explore the susceptibility, and we established an animal model. We then used virus-like particles (VLPs) of HEV-1 (HEV-1 VLPs) and HEV-3 (HEV-3 VLPs), a candidate hepatitis E vaccine, to intramuscularly inoculate rhesus monkeys. The monkeys elicited IgG antibody titers as high as >1:102,400 against heterologous HEV-7 without any adjuvants. The HEV-1 VLPs and HEV-3 VLPs-immunized monkeys were challenged intravenously with HEV-7, and they were protected completely from the infection, demonstrating that these VLPs could be a usable vaccine against HEV-7 infection. We also observed that HEV-7-infected rhesus monkeys did not show any liver damage during these experiments. Further efforts are necessary to establish an animal model for investigation of the pathogenesis of hepatitis E caused by HEV-7 infection.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2020.09.036</identifier><identifier>PMID: 32980200</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adjuvants ; Animal models ; Animals ; Antibodies ; Antigens ; Camels ; Camelus ; Cell culture ; Dromedary camel hepatitis E virus ; Experiments ; Feces ; Genomes ; Genotypes ; Hepatitis ; Hepatitis E - prevention & control ; Hepatitis E - veterinary ; Hepatitis E virus ; Hepeviridae ; HEV-7 ; Humans ; IgG antibody ; Immunization ; Immunoglobulin G ; Infections ; Laboratories ; Membrane filters ; Monkeys ; Monkeys & apes ; Pathogenesis ; Proteins ; Vaccination ; Vaccine ; Vaccines ; Virus-like particle ; Virus-like particles ; Viruses ; Zoonoses ; Zoonotic infection</subject><ispartof>Vaccine, 2020-10, Vol.38 (46), p.7316-7322</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-46920ffc1e50fe13a9d023829c9b33155718e0a618703d775d2b731eefdd0bb13</citedby><cites>FETCH-LOGICAL-c440t-46920ffc1e50fe13a9d023829c9b33155718e0a618703d775d2b731eefdd0bb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32980200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Yingqiu</creatorcontrib><creatorcontrib>Yang, Fengmei</creatorcontrib><creatorcontrib>Xu, Xingli</creatorcontrib><creatorcontrib>Feng, Min</creatorcontrib><creatorcontrib>Liao, Yun</creatorcontrib><creatorcontrib>He, Zhanlong</creatorcontrib><creatorcontrib>Takeda, Naokazu</creatorcontrib><creatorcontrib>Muramatsu, Masamichi</creatorcontrib><creatorcontrib>Li, Qihan</creatorcontrib><creatorcontrib>Li, Tian-Cheng</creatorcontrib><title>Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Dromedary camel hepatitis E virus is a novel HEV that belongs to the family Hepeviridae, and is classified as genotype 7 HEV (HEV-7). 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Further efforts are necessary to establish an animal model for investigation of the pathogenesis of hepatitis E caused by HEV-7 infection.</description><subject>Adjuvants</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Camels</subject><subject>Camelus</subject><subject>Cell culture</subject><subject>Dromedary camel hepatitis E virus</subject><subject>Experiments</subject><subject>Feces</subject><subject>Genomes</subject><subject>Genotypes</subject><subject>Hepatitis</subject><subject>Hepatitis E - prevention & control</subject><subject>Hepatitis E - veterinary</subject><subject>Hepatitis E virus</subject><subject>Hepeviridae</subject><subject>HEV-7</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immunization</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Membrane filters</subject><subject>Monkeys</subject><subject>Monkeys & apes</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Vaccination</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Virus-like particle</subject><subject>Virus-like particles</subject><subject>Viruses</subject><subject>Zoonoses</subject><subject>Zoonotic infection</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkUtr3DAUhUVoaKZpf0KCoJtu7Fy9_FiVEpImEOgmge6ELF1nNNjyVLIHkl9fJTPpol10deHynXMfh5AzBiUDVl1syp2x1gcsOXAooS1BVEdkxZpaFFyx5h1ZAa9kIRn8PCEfUtoAgBKsfU9OBG-brIIVGW_HcQn-2cx-CnTq6XoZTaBr3ObO7BO9ojsfl4SJ2in0GCM6uo3TjPZVYR6ND2mmdm2GAcMj0u6JGmrNiMO_Lh_JcW-GhJ8O9ZQ8XF_dX94Udz--315-uyuslDAXsmo59L1lqKBHJkzrgIuGt7bthGBK1axBMFW-FYSra-V4VwuG2DsHXcfEKfmy982b_lowzXr0yeIwmIDTkjSXeUTTMAkZ_fwXupmWGPJ2mVJQKy6kzJTaUzZOKUXs9Tb60cQnzUC_5KE3-pCHfslDQ6tzHll3fnBfuhHdH9VbABn4ugcwv2PnMepkPQaLzsf8Yu0m_58RvwFZY564</recordid><startdate>20201027</startdate><enddate>20201027</enddate><creator>Guo, Yingqiu</creator><creator>Yang, Fengmei</creator><creator>Xu, Xingli</creator><creator>Feng, Min</creator><creator>Liao, Yun</creator><creator>He, Zhanlong</creator><creator>Takeda, Naokazu</creator><creator>Muramatsu, Masamichi</creator><creator>Li, Qihan</creator><creator>Li, Tian-Cheng</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20201027</creationdate><title>Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus</title><author>Guo, Yingqiu ; Yang, Fengmei ; Xu, Xingli ; Feng, Min ; Liao, Yun ; He, Zhanlong ; Takeda, Naokazu ; Muramatsu, Masamichi ; Li, Qihan ; Li, Tian-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-46920ffc1e50fe13a9d023829c9b33155718e0a618703d775d2b731eefdd0bb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adjuvants</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Camels</topic><topic>Camelus</topic><topic>Cell culture</topic><topic>Dromedary camel hepatitis E virus</topic><topic>Experiments</topic><topic>Feces</topic><topic>Genomes</topic><topic>Genotypes</topic><topic>Hepatitis</topic><topic>Hepatitis E - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Yingqiu</au><au>Yang, Fengmei</au><au>Xu, Xingli</au><au>Feng, Min</au><au>Liao, Yun</au><au>He, Zhanlong</au><au>Takeda, Naokazu</au><au>Muramatsu, Masamichi</au><au>Li, Qihan</au><au>Li, Tian-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2020-10-27</date><risdate>2020</risdate><volume>38</volume><issue>46</issue><spage>7316</spage><epage>7322</epage><pages>7316-7322</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Dromedary camel hepatitis E virus is a novel HEV that belongs to the family Hepeviridae, and is classified as genotype 7 HEV (HEV-7). Since HEV-7 is transmitted from camels to humans and causes acute hepatitis E, this virus is a non-negligible pathogen for zoonosis, and a vaccine against HEV-7 infection is urgently needed. Here, we first intravenously inoculated HEV-7 to rhesus monkeys to explore the susceptibility, and we established an animal model. We then used virus-like particles (VLPs) of HEV-1 (HEV-1 VLPs) and HEV-3 (HEV-3 VLPs), a candidate hepatitis E vaccine, to intramuscularly inoculate rhesus monkeys. The monkeys elicited IgG antibody titers as high as >1:102,400 against heterologous HEV-7 without any adjuvants. The HEV-1 VLPs and HEV-3 VLPs-immunized monkeys were challenged intravenously with HEV-7, and they were protected completely from the infection, demonstrating that these VLPs could be a usable vaccine against HEV-7 infection. We also observed that HEV-7-infected rhesus monkeys did not show any liver damage during these experiments. Further efforts are necessary to establish an animal model for investigation of the pathogenesis of hepatitis E caused by HEV-7 infection.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32980200</pmid><doi>10.1016/j.vaccine.2020.09.036</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adjuvants Animal models Animals Antibodies Antigens Camels Camelus Cell culture Dromedary camel hepatitis E virus Experiments Feces Genomes Genotypes Hepatitis Hepatitis E - prevention & control Hepatitis E - veterinary Hepatitis E virus Hepeviridae HEV-7 Humans IgG antibody Immunization Immunoglobulin G Infections Laboratories Membrane filters Monkeys Monkeys & apes Pathogenesis Proteins Vaccination Vaccine Vaccines Virus-like particle Virus-like particles Viruses Zoonoses Zoonotic infection |
| title | Immunization of human hepatitis E viruses conferred protection against challenge by a camel hepatitis E virus |
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