MST1 modulates Th17 activation in psoriasis via regulating TLR4-NF-κB pathway

Psoriasis is a chronic inflammatory skin disease which mainly involves immune system. This research was to investigate the role of MST1 in the psoriasis, and the detailed mechanism whether related with Th17 and NF-κB. The skin samples and peripheral blood were obtained from psoriasis patients. Skin...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2021, Vol.34 (1), p.28-36
Main Authors: Tang, Huayang, Guo, Ze, Tang, Xianfa, Gao, Jinping, Wang, Wenjun, Huang, He, Zheng, Xiaodong, Cheng, Hui, Sheng, Yujun, Sun, Liangdan
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
CD4 antigen
CD8 antigen
Cell Biology
Cell migration
Cell proliferation
Gynecology
Helper cells
Immune system
Interleukin 1
Interleukin 17
Interleukin 22
Life Sciences
Lymphocytes
Lymphocytes T
NF-κB protein
Oncology
Peripheral blood
Psoriasis
Reproductive Medicine
Research Article
Signal transduction
Skin diseases
Stem Cells
Surgery
TLR4 protein
Toll-like receptors
Tumor necrosis factor-α
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Summary:Psoriasis is a chronic inflammatory skin disease which mainly involves immune system. This research was to investigate the role of MST1 in the psoriasis, and the detailed mechanism whether related with Th17 and NF-κB. The skin samples and peripheral blood were obtained from psoriasis patients. Skin samples and T cells isolated from peripheral blood of patients were cultured in vitro. The results showed that the level of MST1 in the lesional skin of all three patients was higher than that of un-lesional skin, as well as the amount of CD4, CD8 and IL17 positive T cells. The amount of circulating Th17 was higher than that of control. The level of MST1, IL-17, IL-22 and TNFα was enhanced in activated T cells ( p  
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-020-00423-w