Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study

Background and Objectives Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appear...

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Bibliographic Details
Published in:Lasers in surgery and medicine 2021-04, Vol.53 (4), p.482-487
Main Authors: Fawzi, Marwa M.T., Gawdat, Heba I., Mahmoud, Sara B., El‐Hawary, Marwa S., Rashed, Laila A., Esmat, Samia M.
Format: Article
Language:English
Subjects:
Ablation
Amyloidosis
Amyloidosis, Familial
Carbon dioxide
Carbon dioxide lasers
Cytokines
fractional carbon dioxide laser
Health services
Humans
IL‐31 receptor
Interleukins
interleukin‐31
Lasers
Lasers, Gas - therapeutic use
Patients
Polymerase chain reaction
primary cutaneous amyloidosis
Pruritus
Pruritus - etiology
Receptors
Skin Diseases, Genetic
Statistical analysis
Treatment Outcome
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Summary:Background and Objectives Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appearance, histological pattern, and pruritus. The aim of this study is to assess the effect of fractional CO2 laser on pruritus associated with PCA, and analyze whether this effect is related to IL‐31 and IL‐31 receptor (R) expression. Study Design/Materials and Methods The study included 24 patients with PCA and 24 healthy controls. Each patient received four fractional CO2 laser sessions, 4 weeks apart, using the superficial ablative mode. Skin biopsies were taken from patients before and after treatment, as well as controls, for assessment of IL‐31 and IL‐31R by real‐time polymerase chain reaction. Results Treatment resulted in significant improvement of all clinical parameters, including pruritus (P 
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.23313