Loading…
Animal models of psoriasis—highlights and drawbacks
Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-...
Saved in:
Published in: | Journal of allergy and clinical immunology 2021-02, Vol.147 (2), p.439-455 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53 |
---|---|
cites | cdi_FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53 |
container_end_page | 455 |
container_issue | 2 |
container_start_page | 439 |
container_title | Journal of allergy and clinical immunology |
container_volume | 147 |
creator | Schön, Michael P. Manzke, Veit Erpenbeck, Luise |
description | Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called “psoriasiform”, “psoriasis-like” or even “psoriasis” usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models. |
doi_str_mv | 10.1016/j.jaci.2020.04.034 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2415297806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674920306308</els_id><sourcerecordid>2415297806</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53</originalsourceid><addsrcrecordid>eNp9kEtOwzAQhi0EoqVwARYoSzYJYyexY4lNVfGSkNjA2nL8oA55FDsFseMQnJCT4KqFJYvRaKRv_tF8CJ1iyDBgetFkjVQuI0AggyKDvNhDUwycpbQi5T6aAnCcUlbwCToKoYE45xU_RJOclDRyeIrKee862SbdoE0bksEmqzB4J4ML359fS_e8bGONIZG9TrSX77VUL-EYHVjZBnOy6zP0dH31uLhN7x9u7hbz-1QVAGOKGbGU5nUpSc2spVYqyXiV43hfW6kl1bU0IIuSEmYooQxTBbXhFsByVeYzdL7NXfnhdW3CKDoXlGlb2ZthHQQpcEk4q4BGlGxR5YcQvLFi5eNn_kNgEBtdohEbXWKjS0Ahoq64dLbLX9ed0X8rv34icLkFohzz5owXQTnTK6OdN2oUenD_5f8Agut8GQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2415297806</pqid></control><display><type>article</type><title>Animal models of psoriasis—highlights and drawbacks</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Schön, Michael P. ; Manzke, Veit ; Erpenbeck, Luise</creator><creatorcontrib>Schön, Michael P. ; Manzke, Veit ; Erpenbeck, Luise</creatorcontrib><description>Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called “psoriasiform”, “psoriasis-like” or even “psoriasis” usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2020.04.034</identifier><identifier>PMID: 32560971</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>adoptive transfer ; animal model ; chronic inflammation ; dermatology ; drug testing ; epidermis ; hyperproliferation ; imiquimod ; preclinical ; preclinical therapeutic study ; Psoriasis ; skin immunity ; skin inflammation ; transgenic ; xenotransplantation</subject><ispartof>Journal of allergy and clinical immunology, 2021-02, Vol.147 (2), p.439-455</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53</citedby><cites>FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32560971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schön, Michael P.</creatorcontrib><creatorcontrib>Manzke, Veit</creatorcontrib><creatorcontrib>Erpenbeck, Luise</creatorcontrib><title>Animal models of psoriasis—highlights and drawbacks</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called “psoriasiform”, “psoriasis-like” or even “psoriasis” usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models.</description><subject>adoptive transfer</subject><subject>animal model</subject><subject>chronic inflammation</subject><subject>dermatology</subject><subject>drug testing</subject><subject>epidermis</subject><subject>hyperproliferation</subject><subject>imiquimod</subject><subject>preclinical</subject><subject>preclinical therapeutic study</subject><subject>Psoriasis</subject><subject>skin immunity</subject><subject>skin inflammation</subject><subject>transgenic</subject><subject>xenotransplantation</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtOwzAQhi0EoqVwARYoSzYJYyexY4lNVfGSkNjA2nL8oA55FDsFseMQnJCT4KqFJYvRaKRv_tF8CJ1iyDBgetFkjVQuI0AggyKDvNhDUwycpbQi5T6aAnCcUlbwCToKoYE45xU_RJOclDRyeIrKee862SbdoE0bksEmqzB4J4ML359fS_e8bGONIZG9TrSX77VUL-EYHVjZBnOy6zP0dH31uLhN7x9u7hbz-1QVAGOKGbGU5nUpSc2spVYqyXiV43hfW6kl1bU0IIuSEmYooQxTBbXhFsByVeYzdL7NXfnhdW3CKDoXlGlb2ZthHQQpcEk4q4BGlGxR5YcQvLFi5eNn_kNgEBtdohEbXWKjS0Ahoq64dLbLX9ed0X8rv34icLkFohzz5owXQTnTK6OdN2oUenD_5f8Agut8GQ</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Schön, Michael P.</creator><creator>Manzke, Veit</creator><creator>Erpenbeck, Luise</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202102</creationdate><title>Animal models of psoriasis—highlights and drawbacks</title><author>Schön, Michael P. ; Manzke, Veit ; Erpenbeck, Luise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>adoptive transfer</topic><topic>animal model</topic><topic>chronic inflammation</topic><topic>dermatology</topic><topic>drug testing</topic><topic>epidermis</topic><topic>hyperproliferation</topic><topic>imiquimod</topic><topic>preclinical</topic><topic>preclinical therapeutic study</topic><topic>Psoriasis</topic><topic>skin immunity</topic><topic>skin inflammation</topic><topic>transgenic</topic><topic>xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schön, Michael P.</creatorcontrib><creatorcontrib>Manzke, Veit</creatorcontrib><creatorcontrib>Erpenbeck, Luise</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schön, Michael P.</au><au>Manzke, Veit</au><au>Erpenbeck, Luise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Animal models of psoriasis—highlights and drawbacks</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>147</volume><issue>2</issue><spage>439</spage><epage>455</epage><pages>439-455</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called “psoriasiform”, “psoriasis-like” or even “psoriasis” usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32560971</pmid><doi>10.1016/j.jaci.2020.04.034</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0091-6749 |
ispartof | Journal of allergy and clinical immunology, 2021-02, Vol.147 (2), p.439-455 |
issn | 0091-6749 1097-6825 |
language | eng |
recordid | cdi_proquest_miscellaneous_2415297806 |
source | ScienceDirect Freedom Collection 2022-2024 |
subjects | adoptive transfer animal model chronic inflammation dermatology drug testing epidermis hyperproliferation imiquimod preclinical preclinical therapeutic study Psoriasis skin immunity skin inflammation transgenic xenotransplantation |
title | Animal models of psoriasis—highlights and drawbacks |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T05%3A16%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Animal%20models%20of%20psoriasis%E2%80%94highlights%20and%20drawbacks&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Sch%C3%B6n,%20Michael%20P.&rft.date=2021-02&rft.volume=147&rft.issue=2&rft.spage=439&rft.epage=455&rft.pages=439-455&rft.issn=0091-6749&rft.eissn=1097-6825&rft_id=info:doi/10.1016/j.jaci.2020.04.034&rft_dat=%3Cproquest_cross%3E2415297806%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c400t-172f663b5a2b7ff6faca79831325dfada6dbae0a45627e626716c0be9f00f9c53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2415297806&rft_id=info:pmid/32560971&rfr_iscdi=true |