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Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome
Introduction Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and o...
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| Published in: | International ophthalmology 2020-10, Vol.40 (10), p.2475-2485 |
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| container_end_page | 2485 |
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| container_title | International ophthalmology |
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| creator | Batum, Melike Kısabay, Ayşın Mayalı, Hüseyin Göktalay, Tuğba Kurt, Emin Selçuki, Deniz Yılmaz, Hikmet |
| description | Introduction
Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers.
Objectives
To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS.
Materials and methods
Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared.
Results
In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (
p
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| doi_str_mv | 10.1007/s10792-020-01426-0 |
| format | article |
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Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers.
Objectives
To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS.
Materials and methods
Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared.
Results
In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (
p
< 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75–P100 waves.
In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75–P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea.
Discussion
It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-020-01426-0</identifier><identifier>PMID: 32506292</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper</subject><ispartof>International ophthalmology, 2020-10, Vol.40 (10), p.2475-2485</ispartof><rights>Springer Nature B.V. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-611b3551df695c0e37277ed590c19d62d03885068b432f604111640aaa35fa8a3</citedby><cites>FETCH-LOGICAL-c347t-611b3551df695c0e37277ed590c19d62d03885068b432f604111640aaa35fa8a3</cites><orcidid>0000-0002-0627-8914 ; 0000-0002-5728-9824</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32506292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batum, Melike</creatorcontrib><creatorcontrib>Kısabay, Ayşın</creatorcontrib><creatorcontrib>Mayalı, Hüseyin</creatorcontrib><creatorcontrib>Göktalay, Tuğba</creatorcontrib><creatorcontrib>Kurt, Emin</creatorcontrib><creatorcontrib>Selçuki, Deniz</creatorcontrib><creatorcontrib>Yılmaz, Hikmet</creatorcontrib><title>Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Introduction
Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers.
Objectives
To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS.
Materials and methods
Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared.
Results
In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (
p
< 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75–P100 waves.
In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75–P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea.
Discussion
It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAURi0EokPhBVggL9kEru38TJaoagGpEhtYW45zM3Gb2MHXSTUPzHvg6RTEipUt3-87tnwYeyvggwBoPpKAppUFSChAlLIu4BnbiapRhawVPGc7EHVVVA2IC_aK6A4A2qatX7ILJSuoZSt37Nf1ZqbVJBc8DwPHYUCb6LRdArnkNuTGxQdz5EtEojUiTxFNmtEnnjsRk_Nm4oPrMPI0Onvvc44b3_PN0ZpHi0ljBhBfyfkDD0tyltswYkRvMy7M4RDNMh7_LeEW7rHPj0j5Imcm4s5nPJ5oLh8Rf3Bp5IRbxvDQUYqrfXwuTYgLN4tHw-no-xhmfM1eDJmBb57WS_bj5vr71Zfi9tvnr1efbguryiYVtRCdqirRD3VbWUDVyKbBvmrBiravZQ9qv88_t-9KJYcaSiFEXYIxRlWD2Rt1yd6fuUsMP1ekpGdHFqfJeAwraVlmZVA2QuWoPEdtDEQRB71EN5t41AL0Sa8-69VZr37UqyGX3j3x127G_m_lj88cUOcA5ZE_YNR3YY1ZEP0P-xsIvrcn</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Batum, Melike</creator><creator>Kısabay, Ayşın</creator><creator>Mayalı, Hüseyin</creator><creator>Göktalay, Tuğba</creator><creator>Kurt, Emin</creator><creator>Selçuki, Deniz</creator><creator>Yılmaz, Hikmet</creator><general>Springer Netherlands</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0627-8914</orcidid><orcidid>https://orcid.org/0000-0002-5728-9824</orcidid></search><sort><creationdate>20201001</creationdate><title>Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome</title><author>Batum, Melike ; Kısabay, Ayşın ; Mayalı, Hüseyin ; Göktalay, Tuğba ; Kurt, Emin ; Selçuki, Deniz ; Yılmaz, Hikmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-611b3551df695c0e37277ed590c19d62d03885068b432f604111640aaa35fa8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batum, Melike</creatorcontrib><creatorcontrib>Kısabay, Ayşın</creatorcontrib><creatorcontrib>Mayalı, Hüseyin</creatorcontrib><creatorcontrib>Göktalay, Tuğba</creatorcontrib><creatorcontrib>Kurt, Emin</creatorcontrib><creatorcontrib>Selçuki, Deniz</creatorcontrib><creatorcontrib>Yılmaz, Hikmet</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batum, Melike</au><au>Kısabay, Ayşın</au><au>Mayalı, Hüseyin</au><au>Göktalay, Tuğba</au><au>Kurt, Emin</au><au>Selçuki, Deniz</au><au>Yılmaz, Hikmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>40</volume><issue>10</issue><spage>2475</spage><epage>2485</epage><pages>2475-2485</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Introduction
Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers.
Objectives
To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS.
Materials and methods
Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared.
Results
In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (
p
< 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75–P100 waves.
In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75–P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea.
Discussion
It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32506292</pmid><doi>10.1007/s10792-020-01426-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0627-8914</orcidid><orcidid>https://orcid.org/0000-0002-5728-9824</orcidid></addata></record> |
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| title | Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome |
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