Impact of renal dysfunction and acute kidney injury on outcome in elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention

Abstract Background Chronic kidney disease is common in patients admitted with acute coronary syndrome and its prevalence dramatically increases with age. Understanding the determinants of adverse outcomes in this extremely high-risk population may be useful for the development of specific treatment...

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Published in:European heart journal. Acute cardiovascular care 2021-12, Vol.10 (10), p.1160-1169
Main Authors: De Rosa, Roberta, Morici, Nuccia, De Servi, Stefano, De Luca, Giuseppe, Galasso, Gennaro, Piscione, Federico, Ferri, Luca A, Piatti, Luigi, Grosseto, Daniele, Tortorella, Giovanni, Franco, Nicoletta, Lenatti, Laura, Misuraca, Leonardo, Leuzzi, Chiara, Verdoia, Monica, Sganzerla, Paolo, Cacucci, Michele, Ferrario, Maurizio, Murena, Ernesto, Sibilio, Gerolamo, Toso, Anna, Savonitto, Stefano
Format: Article
Language:English
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Summary:Abstract Background Chronic kidney disease is common in patients admitted with acute coronary syndrome and its prevalence dramatically increases with age. Understanding the determinants of adverse outcomes in this extremely high-risk population may be useful for the development of specific treatment strategies and planning of secondary prevention modalities. Aim The aim of this study was to assess the impact of baseline renal function and acute kidney injury on one-year outcome of elderly patients with acute coronary syndrome treated with percutaneous coronary intervention. Methods Patients aged 75 years and older with acute coronary syndrome undergoing successful percutaneous coronary intervention were selected among those enrolled in three Italian multicentre studies. Based on the baseline estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault formula ([(140–age) × body weight × 0.85 if female]/(72 × serum creatinine)* 1.73 m2 of body surface area), patients were classified as having none or mild (eGFR ≥60 ml/min/1.73 m2), moderate (eGFR 30–59 ml/min/1.73 m2) or severe (eGFR
ISSN:2048-8726
2048-8734
2048-8734
DOI:10.1177/2048872620920475