Restoring the Sense of Touch Using a Sensorimotor Demultiplexing Neural Interface

Paralyzed muscles can be reanimated following spinal cord injury (SCI) using a brain-computer interface (BCI) to enhance motor function alone. Importantly, the sense of touch is a key component of motor function. Here, we demonstrate that a human participant with a clinically complete SCI can use a...

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Bibliographic Details
Published in:Cell 2020-05, Vol.181 (4), p.763-773.e12
Main Authors: Ganzer, Patrick D., Colachis, Samuel C., Schwemmer, Michael A., Friedenberg, David A., Dunlap, Collin F., Swiftney, Carly E., Jacobowitz, Adam F., Weber, Doug J., Bockbrader, Marcia A., Sharma, Gaurav
Format: Article
Language:English
Subjects:
Adult
brain-computer interface
Brain-Computer Interfaces - psychology
cortex
decoding
demultiplex
Feedback, Sensory - physiology
Hand - physiopathology
Hand Strength - physiology
Humans
machine learning
Male
Motor Cortex - physiology
Movement - physiology
sensory feedback
Spinal Cord Injuries - physiopathology
spinal cord injury
touch
Touch - physiology
Touch Perception - physiology
upper limb
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Summary:Paralyzed muscles can be reanimated following spinal cord injury (SCI) using a brain-computer interface (BCI) to enhance motor function alone. Importantly, the sense of touch is a key component of motor function. Here, we demonstrate that a human participant with a clinically complete SCI can use a BCI to simultaneously reanimate both motor function and the sense of touch, leveraging residual touch signaling from his own hand. In the primary motor cortex (M1), residual subperceptual hand touch signals are simultaneously demultiplexed from ongoing efferent motor intention, enabling intracortically controlled closed-loop sensory feedback. Using the closed-loop demultiplexing BCI almost fully restored the ability to detect object touch and significantly improved several sensorimotor functions. Afferent grip-intensity levels are also decoded from M1, enabling grip reanimation regulated by touch signaling. These results demonstrate that subperceptual neural signals can be decoded from the cortex and transformed into conscious perception, significantly augmenting function. [Display omitted] •Following spinal cord injury, subperceptual touch signals affect the human motor cortex•A brain-computer interface uses subperceptual signals to restore the sense of touch•Sensorimotor function is further enhanced using demultiplexed sensorimotor signals•Touch-regulated grip force can automate movement cascades and grip reanimation Sensation is restored to the hand of a participant with quadriplegia by a brain-computer interface that transforms residual, subperceptual touch signals into conscious perception.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2020.03.054