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Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study
Pityriasis versicolor (PV) is a chronic superficial fungal infection. Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was co...
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Published in: | Dermatologic therapy 2020-05, Vol.33 (3), p.e13319-n/a |
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description | Pityriasis versicolor (PV) is a chronic superficial fungal infection. Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was conducted on 90 PV patients divided into three equal groups. GI was treated with topical ketoconazole 2% cream twice daily and placebo, GII was treated with topical 0.1% adapalene gel twice daily and placebo and GIII was treated with topical combination of 0.1% adapalene gel (at night) and ketoconazole 2% cream (in the morning). All patients received medications for 4 weeks. Evaluation was done at 2 and 4 weeks and included clinical assessment, laboratory assessment, and patient satisfaction. We found that after 4 weeks of treatment, all groups showed significant improvement. There was better response in GIII in terms of lower rate of positive potassium hydroxide staining, higher rate of significantly improved cases and higher rate of well‐satisfied patients. However, the difference fell short of statistical significance. We concluded that a combination of adapalene gel and ketoconazole cream is very effective in treatment of PV with no or mild side effects. |
doi_str_mv | 10.1111/dth.13319 |
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Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was conducted on 90 PV patients divided into three equal groups. GI was treated with topical ketoconazole 2% cream twice daily and placebo, GII was treated with topical 0.1% adapalene gel twice daily and placebo and GIII was treated with topical combination of 0.1% adapalene gel (at night) and ketoconazole 2% cream (in the morning). All patients received medications for 4 weeks. Evaluation was done at 2 and 4 weeks and included clinical assessment, laboratory assessment, and patient satisfaction. We found that after 4 weeks of treatment, all groups showed significant improvement. There was better response in GIII in terms of lower rate of positive potassium hydroxide staining, higher rate of significantly improved cases and higher rate of well‐satisfied patients. However, the difference fell short of statistical significance. We concluded that a combination of adapalene gel and ketoconazole cream is very effective in treatment of PV with no or mild side effects.</description><identifier>ISSN: 1396-0296</identifier><identifier>EISSN: 1529-8019</identifier><identifier>DOI: 10.1111/dth.13319</identifier><identifier>PMID: 32182387</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acne Vulgaris - drug therapy ; Adapalene ; Dermatologic Agents - adverse effects ; Gels ; Humans ; ketoconazole ; Ketoconazole - adverse effects ; Ointments ; pityriasis versicolor ; Tinea Versicolor - diagnosis ; Tinea Versicolor - drug therapy ; Treatment Outcome</subject><ispartof>Dermatologic therapy, 2020-05, Vol.33 (3), p.e13319-n/a</ispartof><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3609-995f7c6d8090c9a29c4f369fac91490af24f9a8705d0ac1ed2df068888c097c93</citedby><cites>FETCH-LOGICAL-c3609-995f7c6d8090c9a29c4f369fac91490af24f9a8705d0ac1ed2df068888c097c93</cites><orcidid>0000-0002-4126-7962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdth.13319$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdth.13319$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32182387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakr, Essam</creatorcontrib><creatorcontrib>Abdo, Hamed</creatorcontrib><creatorcontrib>Abd‐Elaziz, Hassan</creatorcontrib><creatorcontrib>Abd‐Elrazek, Hazem</creatorcontrib><creatorcontrib>Amer, Mohamed</creatorcontrib><title>Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study</title><title>Dermatologic therapy</title><addtitle>Dermatol Ther</addtitle><description>Pityriasis versicolor (PV) is a chronic superficial fungal infection. Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was conducted on 90 PV patients divided into three equal groups. GI was treated with topical ketoconazole 2% cream twice daily and placebo, GII was treated with topical 0.1% adapalene gel twice daily and placebo and GIII was treated with topical combination of 0.1% adapalene gel (at night) and ketoconazole 2% cream (in the morning). All patients received medications for 4 weeks. Evaluation was done at 2 and 4 weeks and included clinical assessment, laboratory assessment, and patient satisfaction. We found that after 4 weeks of treatment, all groups showed significant improvement. There was better response in GIII in terms of lower rate of positive potassium hydroxide staining, higher rate of significantly improved cases and higher rate of well‐satisfied patients. However, the difference fell short of statistical significance. We concluded that a combination of adapalene gel and ketoconazole cream is very effective in treatment of PV with no or mild side effects.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Adapalene</subject><subject>Dermatologic Agents - adverse effects</subject><subject>Gels</subject><subject>Humans</subject><subject>ketoconazole</subject><subject>Ketoconazole - adverse effects</subject><subject>Ointments</subject><subject>pityriasis versicolor</subject><subject>Tinea Versicolor - diagnosis</subject><subject>Tinea Versicolor - drug therapy</subject><subject>Treatment Outcome</subject><issn>1396-0296</issn><issn>1529-8019</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kD1vFDEQQC0URD6g4A-gaSJBsYk_7nZ30p0CIUiRaEK9cuwxceK1D9uX6FLzwzFcoGOameLNKx5jbwU_EW1Obb09EUoJfMEOxFJiN3KBe-1W2HdcYr_PDku541xIVOIV21dSjFKNwwH7ubJ6rQNFgu8UoAmP4aHAPdVkUtRPKRCYTHoGeQw6Wqi35DOYNN_4qKtPEXyE2og6U6yQHKx93Waviy_wQLl4k0LKZ7CC3P7T7J_Iggk-eqMDlLqx29fspdOh0JvnfcS-XXy6Pr_srr5-_nK-uuqM6jl2iEs3mN6OHLlBLdEsnOrRaYNigVw7uXCox4EvLddGkJXW8X5sYzgOBtURe7_zrnP6saFSp9kXQyHoSGlTJqmGcRyw50NDP-xQk1Mpmdy0zn7WeTsJPv2OPrXo05_ojX33rN3czGT_kX8rN-B0Bzz6QNv_m6aP15c75S8PY4w7</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Bakr, Essam</creator><creator>Abdo, Hamed</creator><creator>Abd‐Elaziz, Hassan</creator><creator>Abd‐Elrazek, Hazem</creator><creator>Amer, Mohamed</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4126-7962</orcidid></search><sort><creationdate>202005</creationdate><title>Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study</title><author>Bakr, Essam ; Abdo, Hamed ; Abd‐Elaziz, Hassan ; Abd‐Elrazek, Hazem ; Amer, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3609-995f7c6d8090c9a29c4f369fac91490af24f9a8705d0ac1ed2df068888c097c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Adapalene</topic><topic>Dermatologic Agents - adverse effects</topic><topic>Gels</topic><topic>Humans</topic><topic>ketoconazole</topic><topic>Ketoconazole - adverse effects</topic><topic>Ointments</topic><topic>pityriasis versicolor</topic><topic>Tinea Versicolor - diagnosis</topic><topic>Tinea Versicolor - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakr, Essam</creatorcontrib><creatorcontrib>Abdo, Hamed</creatorcontrib><creatorcontrib>Abd‐Elaziz, Hassan</creatorcontrib><creatorcontrib>Abd‐Elrazek, Hazem</creatorcontrib><creatorcontrib>Amer, Mohamed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakr, Essam</au><au>Abdo, Hamed</au><au>Abd‐Elaziz, Hassan</au><au>Abd‐Elrazek, Hazem</au><au>Amer, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study</atitle><jtitle>Dermatologic therapy</jtitle><addtitle>Dermatol Ther</addtitle><date>2020-05</date><risdate>2020</risdate><volume>33</volume><issue>3</issue><spage>e13319</spage><epage>n/a</epage><pages>e13319-n/a</pages><issn>1396-0296</issn><eissn>1529-8019</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><abstract>Pityriasis versicolor (PV) is a chronic superficial fungal infection. Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was conducted on 90 PV patients divided into three equal groups. GI was treated with topical ketoconazole 2% cream twice daily and placebo, GII was treated with topical 0.1% adapalene gel twice daily and placebo and GIII was treated with topical combination of 0.1% adapalene gel (at night) and ketoconazole 2% cream (in the morning). All patients received medications for 4 weeks. Evaluation was done at 2 and 4 weeks and included clinical assessment, laboratory assessment, and patient satisfaction. We found that after 4 weeks of treatment, all groups showed significant improvement. There was better response in GIII in terms of lower rate of positive potassium hydroxide staining, higher rate of significantly improved cases and higher rate of well‐satisfied patients. However, the difference fell short of statistical significance. We concluded that a combination of adapalene gel and ketoconazole cream is very effective in treatment of PV with no or mild side effects.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32182387</pmid><doi>10.1111/dth.13319</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4126-7962</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acne Vulgaris - drug therapy Adapalene Dermatologic Agents - adverse effects Gels Humans ketoconazole Ketoconazole - adverse effects Ointments pityriasis versicolor Tinea Versicolor - diagnosis Tinea Versicolor - drug therapy Treatment Outcome |
title | Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study |
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