Sex differences in rapid nonclassical action of 17β‐oestradiol on intracellular signalling and oestrogen receptor α expression in basal forebrain cholinergic neurones in mouse

Rapid nonclassical effects of 17β‐oestradiol (E2) on intracellular signalling have been identified in the basal forebrain, although the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element bindi...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2020-01, Vol.32 (1), p.e12830-n/a
Main Authors: Kim, SooHyun, Barad, Zsuzsanna, Cheong, Rachel Y., Ábrahám, István M.
Format: Article
Language:English
Subjects:
17β-Estradiol
Anatomy
Basal forebrain
Brain architecture
cholinergic neurone
CREB
Cyclic AMP response element-binding protein
Females
Forebrain
Intracellular
Intracellular signalling
Males
Neostriatum
nonclassical
oestradiol
oestrogen receptor α
Septum
sex difference
Sex differences
Sexual dimorphism
signalling
Substantia innominata
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Summary:Rapid nonclassical effects of 17β‐oestradiol (E2) on intracellular signalling have been identified in the basal forebrain, although the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element binding protein (CREB) via ΕRα in female cholinergic neurones. Using this indicator, the present study examined whether nonclassical actions of E2 occur in a sexually dimorphic manner within basal forebrain cholinergic neurones in mice. In addition, we investigated the expression and intracellular distribution of oestrogen receptor (ΕR)α in cholinergic neurones in female and male mice. Animals were gonadectomised and treated 2 weeks later with E2. The number of CREB‐expressing cholinergic neurones was not altered in any of the brain regions after E2 treatment in both males and females. However, E2 treatment rapidly (
ISSN:0953-8194
1365-2826
DOI:10.1111/jne.12830