Passive exposure of non-smokers to E-Cigarette aerosols: Sensory irritation, timing and association with volatile organic compounds

The current study examined symptoms of irritation reported by non-smokers passively exposed to e-cigarette aerosols and their timing and association with the concentrations of volatile organic compounds (VOCs) produced. 40 healthy non-smoking adults were exposed to e-cigarette aerosols for 30 min in...

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Published in:Environmental research 2020-03, Vol.182, p.108963-108963, Article 108963
Main Authors: Tzortzi, Anna, Teloniatis, Stephanie, Matiampa, George, Bakelas, Gerasimos, Tzavara, Chara, Vyzikidou, Vergina Konstantina, Vardavas, Constantine, Behrakis, Panagiotis, Fernandez, Esteve, Fernández, Esteve, Castellano, Yolanda, Fu, Marcela, Amalia, Beladenta, Tigova, Olena, López, Maria José, Continente, Xavier, Arechavala, Teresa, Gallus, Silvano, Lugo, Alessandra, Liu, Xiaoqiu, Bosetti, Cristina, Davoli, Enrico, Doxa, Istituto, Colombo, Paolo, Semple, Sean, O'Donnell, Rachel, Dobson, Ruaraidh, Clancy, Luke, Keogan, Sheila, Li, Shashsa, Breslin, Elizabeth, Gorini, Giuseppe, Carreras, Giulia, Cortini, Barbara, Chellini, Elisabetta, Boffi, Roberto, Ruprecht, Ario, De Marco, Cinzia, Borgini, Alessandro, Veronese, Chiara, Bertoldi, Martina, Tittarelli, Andrea, Nicolás, Ángel López, Trapero-Bertran, Marta, Guerrero, Daniel Celdrán, Radu-Loghin, Cornel, Nguyen, Dominick, Starchenko, Polina, oan B Soriano, Ancochea, Julio, Alonso, Tamara, Pastor, María Teresa, Erro, Marta, Roca, Ana
Format: Article
Language:English
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e-cigarettes
Second-hand aerosol
Sensory irritation
Ultrafine particulates
Volatile organic compounds
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cited_by cdi_FETCH-LOGICAL-c362t-97087ef99feb52462adaacc14f2f3b37fb9ec669d8fc84232011b38a8a5ff58c3
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container_title Environmental research
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creator Tzortzi, Anna
Teloniatis, Stephanie
Matiampa, George
Bakelas, Gerasimos
Tzavara, Chara
Vyzikidou, Vergina Konstantina
Vardavas, Constantine
Behrakis, Panagiotis
Fernandez, Esteve
Fernández, Esteve
Castellano, Yolanda
Fu, Marcela
Amalia, Beladenta
Tigova, Olena
López, Maria José
Continente, Xavier
Arechavala, Teresa
Gallus, Silvano
Lugo, Alessandra
Liu, Xiaoqiu
Bosetti, Cristina
Davoli, Enrico
Doxa, Istituto
Colombo, Paolo
Semple, Sean
O'Donnell, Rachel
Dobson, Ruaraidh
Clancy, Luke
Keogan, Sheila
Li, Shashsa
Breslin, Elizabeth
Behrakis, Panagiotis
Tzortzi, Anna
Vardavas, Constantine
Vyzikidou, Vergina Konstantina
Teloniatis, Stephanie
Bakelas, Gerasimos
Matiampa, George
Gorini, Giuseppe
Carreras, Giulia
Cortini, Barbara
Chellini, Elisabetta
Boffi, Roberto
Ruprecht, Ario
De Marco, Cinzia
Borgini, Alessandro
Veronese, Chiara
Bertoldi, Martina
Tittarelli, Andrea
Nicolás, Ángel López
Trapero-Bertran, Marta
Guerrero, Daniel Celdrán
Radu-Loghin, Cornel
Nguyen, Dominick
Starchenko, Polina
oan B Soriano
Ancochea, Julio
Alonso, Tamara
Pastor, María Teresa
Erro, Marta
Roca, Ana
description The current study examined symptoms of irritation reported by non-smokers passively exposed to e-cigarette aerosols and their timing and association with the concentrations of volatile organic compounds (VOCs) produced. 40 healthy non-smoking adults were exposed to e-cigarette aerosols for 30 min in a 35 m3 room. Second-hand e-cigarette aerosol (SHA) was produced by an experienced e-cigarette user using a standardized topography and two resistance settings (exposure 0.5 Ohm and 1.5 Ohm), in addition to a control session (no emissions). PM2.5 and PM1.0 were continuously measured over the duration of exposure, while Volatile Organic Compounds (VOCs) were recorded at 0, 15 and 30 min (t0, t15 and t30) of exposure. Each participant completed an irritation questionnaire at t0, t15, t30 of exposure and t60 (30 min post-exposure) on ocular, nasal, throat-respiratory symptoms of irritation and general complaints. Kruskal-Wallis H test for PM comparisons, repeated measures ANOVA for VOCs and Generalized Estimating Equations for symptoms of irritation and association with VOCs were used for statistical analysis. 20 males and 20 females, with a mean age of 24.6 years (SD = 4.3) and exhaled CO 
doi_str_mv 10.1016/j.envres.2019.108963
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Second-hand e-cigarette aerosol (SHA) was produced by an experienced e-cigarette user using a standardized topography and two resistance settings (exposure 0.5 Ohm and 1.5 Ohm), in addition to a control session (no emissions). PM2.5 and PM1.0 were continuously measured over the duration of exposure, while Volatile Organic Compounds (VOCs) were recorded at 0, 15 and 30 min (t0, t15 and t30) of exposure. Each participant completed an irritation questionnaire at t0, t15, t30 of exposure and t60 (30 min post-exposure) on ocular, nasal, throat-respiratory symptoms of irritation and general complaints. Kruskal-Wallis H test for PM comparisons, repeated measures ANOVA for VOCs and Generalized Estimating Equations for symptoms of irritation and association with VOCs were used for statistical analysis. 20 males and 20 females, with a mean age of 24.6 years (SD = 4.3) and exhaled CO &lt; 7 ppm participated. PM concentrations in both experimental sessions were higher than the Control (p &lt; 0.001). The most commonly reported symptoms were burning, dryness, sore throat, cough, breathlessness and headache. During both experimental sessions, ocular, nasal, throat-respiratory symptoms and general complaints increased significantly (p &lt; 0.05). Ocular and nasal symptoms returned to baseline by t60 (p &gt; 0.05) while throat-respiratory symptoms were still significantly higher at t60 (p = 0.044). VOCs were significantly associated with reported nasal and throat-respiratory symptoms in both experimental sessions (p &lt; 0.05). A 30-min exposure to SHA provoked symptoms of sensory irritation and general complaints that lasted up to 30 min after the exposure and were positively associated with the concentrations of the VOC mixture emitted. •E-cigarette emits VOCs, PM1.0 and PM2.5 into the environment.•Most common sensory irritation symptoms reported were burning and itchiness.•Passive exposure to e-cigarette aerosols resulted in chemosensory irritation.•Irritation symptoms were related to VOCs concentrations produced.•Throat-respiratory irritation symptoms persisted beyond 30 min after exposure.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2019.108963</identifier><identifier>PMID: 31837549</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>e-cigarettes ; Second-hand aerosol ; Sensory irritation ; Ultrafine particulates ; Volatile organic compounds</subject><ispartof>Environmental research, 2020-03, Vol.182, p.108963-108963, Article 108963</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. 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Second-hand e-cigarette aerosol (SHA) was produced by an experienced e-cigarette user using a standardized topography and two resistance settings (exposure 0.5 Ohm and 1.5 Ohm), in addition to a control session (no emissions). PM2.5 and PM1.0 were continuously measured over the duration of exposure, while Volatile Organic Compounds (VOCs) were recorded at 0, 15 and 30 min (t0, t15 and t30) of exposure. Each participant completed an irritation questionnaire at t0, t15, t30 of exposure and t60 (30 min post-exposure) on ocular, nasal, throat-respiratory symptoms of irritation and general complaints. Kruskal-Wallis H test for PM comparisons, repeated measures ANOVA for VOCs and Generalized Estimating Equations for symptoms of irritation and association with VOCs were used for statistical analysis. 20 males and 20 females, with a mean age of 24.6 years (SD = 4.3) and exhaled CO &lt; 7 ppm participated. PM concentrations in both experimental sessions were higher than the Control (p &lt; 0.001). The most commonly reported symptoms were burning, dryness, sore throat, cough, breathlessness and headache. During both experimental sessions, ocular, nasal, throat-respiratory symptoms and general complaints increased significantly (p &lt; 0.05). Ocular and nasal symptoms returned to baseline by t60 (p &gt; 0.05) while throat-respiratory symptoms were still significantly higher at t60 (p = 0.044). VOCs were significantly associated with reported nasal and throat-respiratory symptoms in both experimental sessions (p &lt; 0.05). A 30-min exposure to SHA provoked symptoms of sensory irritation and general complaints that lasted up to 30 min after the exposure and were positively associated with the concentrations of the VOC mixture emitted. •E-cigarette emits VOCs, PM1.0 and PM2.5 into the environment.•Most common sensory irritation symptoms reported were burning and itchiness.•Passive exposure to e-cigarette aerosols resulted in chemosensory irritation.•Irritation symptoms were related to VOCs concentrations produced.•Throat-respiratory irritation symptoms persisted beyond 30 min after exposure.</description><subject>e-cigarettes</subject><subject>Second-hand aerosol</subject><subject>Sensory irritation</subject><subject>Ultrafine particulates</subject><subject>Volatile organic 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Stephanie ; Bakelas, Gerasimos ; Matiampa, George ; Gorini, Giuseppe ; Carreras, Giulia ; Cortini, Barbara ; Chellini, Elisabetta ; Boffi, Roberto ; Ruprecht, Ario ; De Marco, Cinzia ; Borgini, Alessandro ; Veronese, Chiara ; Bertoldi, Martina ; Tittarelli, Andrea ; Nicolás, Ángel López ; Trapero-Bertran, Marta ; Guerrero, Daniel Celdrán ; Radu-Loghin, Cornel ; Nguyen, Dominick ; Starchenko, Polina ; oan B Soriano ; Ancochea, Julio ; Alonso, Tamara ; Pastor, María Teresa ; Erro, Marta ; Roca, Ana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-97087ef99feb52462adaacc14f2f3b37fb9ec669d8fc84232011b38a8a5ff58c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>e-cigarettes</topic><topic>Second-hand aerosol</topic><topic>Sensory irritation</topic><topic>Ultrafine particulates</topic><topic>Volatile organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tzortzi, Anna</creatorcontrib><creatorcontrib>Teloniatis, Stephanie</creatorcontrib><creatorcontrib>Matiampa, George</creatorcontrib><creatorcontrib>Bakelas, Gerasimos</creatorcontrib><creatorcontrib>Tzavara, Chara</creatorcontrib><creatorcontrib>Vyzikidou, Vergina Konstantina</creatorcontrib><creatorcontrib>Vardavas, Constantine</creatorcontrib><creatorcontrib>Behrakis, Panagiotis</creatorcontrib><creatorcontrib>Fernandez, Esteve</creatorcontrib><creatorcontrib>Fernández, Esteve</creatorcontrib><creatorcontrib>Castellano, Yolanda</creatorcontrib><creatorcontrib>Fu, Marcela</creatorcontrib><creatorcontrib>Amalia, Beladenta</creatorcontrib><creatorcontrib>Tigova, Olena</creatorcontrib><creatorcontrib>López, Maria José</creatorcontrib><creatorcontrib>Continente, Xavier</creatorcontrib><creatorcontrib>Arechavala, Teresa</creatorcontrib><creatorcontrib>Gallus, Silvano</creatorcontrib><creatorcontrib>Lugo, Alessandra</creatorcontrib><creatorcontrib>Liu, Xiaoqiu</creatorcontrib><creatorcontrib>Bosetti, Cristina</creatorcontrib><creatorcontrib>Davoli, Enrico</creatorcontrib><creatorcontrib>Doxa, Istituto</creatorcontrib><creatorcontrib>Colombo, Paolo</creatorcontrib><creatorcontrib>Semple, Sean</creatorcontrib><creatorcontrib>O'Donnell, Rachel</creatorcontrib><creatorcontrib>Dobson, Ruaraidh</creatorcontrib><creatorcontrib>Clancy, Luke</creatorcontrib><creatorcontrib>Keogan, Sheila</creatorcontrib><creatorcontrib>Li, Shashsa</creatorcontrib><creatorcontrib>Breslin, Elizabeth</creatorcontrib><creatorcontrib>Behrakis, Panagiotis</creatorcontrib><creatorcontrib>Tzortzi, Anna</creatorcontrib><creatorcontrib>Vardavas, Constantine</creatorcontrib><creatorcontrib>Vyzikidou, Vergina Konstantina</creatorcontrib><creatorcontrib>Teloniatis, Stephanie</creatorcontrib><creatorcontrib>Bakelas, Gerasimos</creatorcontrib><creatorcontrib>Matiampa, George</creatorcontrib><creatorcontrib>Gorini, Giuseppe</creatorcontrib><creatorcontrib>Carreras, Giulia</creatorcontrib><creatorcontrib>Cortini, Barbara</creatorcontrib><creatorcontrib>Chellini, Elisabetta</creatorcontrib><creatorcontrib>Boffi, Roberto</creatorcontrib><creatorcontrib>Ruprecht, Ario</creatorcontrib><creatorcontrib>De Marco, Cinzia</creatorcontrib><creatorcontrib>Borgini, Alessandro</creatorcontrib><creatorcontrib>Veronese, Chiara</creatorcontrib><creatorcontrib>Bertoldi, Martina</creatorcontrib><creatorcontrib>Tittarelli, Andrea</creatorcontrib><creatorcontrib>Nicolás, Ángel López</creatorcontrib><creatorcontrib>Trapero-Bertran, Marta</creatorcontrib><creatorcontrib>Guerrero, Daniel Celdrán</creatorcontrib><creatorcontrib>Radu-Loghin, Cornel</creatorcontrib><creatorcontrib>Nguyen, Dominick</creatorcontrib><creatorcontrib>Starchenko, Polina</creatorcontrib><creatorcontrib>oan B Soriano</creatorcontrib><creatorcontrib>Ancochea, Julio</creatorcontrib><creatorcontrib>Alonso, Tamara</creatorcontrib><creatorcontrib>Pastor, María Teresa</creatorcontrib><creatorcontrib>Erro, Marta</creatorcontrib><creatorcontrib>Roca, Ana</creatorcontrib><creatorcontrib>TackSHS Project Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tzortzi, Anna</au><au>Teloniatis, Stephanie</au><au>Matiampa, George</au><au>Bakelas, Gerasimos</au><au>Tzavara, Chara</au><au>Vyzikidou, Vergina Konstantina</au><au>Vardavas, Constantine</au><au>Behrakis, Panagiotis</au><au>Fernandez, Esteve</au><au>Fernández, Esteve</au><au>Castellano, Yolanda</au><au>Fu, Marcela</au><au>Amalia, Beladenta</au><au>Tigova, Olena</au><au>López, Maria José</au><au>Continente, Xavier</au><au>Arechavala, Teresa</au><au>Gallus, Silvano</au><au>Lugo, Alessandra</au><au>Liu, Xiaoqiu</au><au>Bosetti, Cristina</au><au>Davoli, Enrico</au><au>Doxa, Istituto</au><au>Colombo, Paolo</au><au>Semple, Sean</au><au>O'Donnell, Rachel</au><au>Dobson, Ruaraidh</au><au>Clancy, Luke</au><au>Keogan, Sheila</au><au>Li, Shashsa</au><au>Breslin, Elizabeth</au><au>Behrakis, Panagiotis</au><au>Tzortzi, Anna</au><au>Vardavas, Constantine</au><au>Vyzikidou, Vergina Konstantina</au><au>Teloniatis, Stephanie</au><au>Bakelas, Gerasimos</au><au>Matiampa, George</au><au>Gorini, Giuseppe</au><au>Carreras, Giulia</au><au>Cortini, Barbara</au><au>Chellini, Elisabetta</au><au>Boffi, Roberto</au><au>Ruprecht, Ario</au><au>De Marco, Cinzia</au><au>Borgini, Alessandro</au><au>Veronese, Chiara</au><au>Bertoldi, Martina</au><au>Tittarelli, Andrea</au><au>Nicolás, Ángel López</au><au>Trapero-Bertran, Marta</au><au>Guerrero, Daniel Celdrán</au><au>Radu-Loghin, Cornel</au><au>Nguyen, Dominick</au><au>Starchenko, Polina</au><au>oan B Soriano</au><au>Ancochea, Julio</au><au>Alonso, Tamara</au><au>Pastor, María Teresa</au><au>Erro, Marta</au><au>Roca, Ana</au><aucorp>TackSHS Project Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Passive exposure of non-smokers to E-Cigarette aerosols: Sensory irritation, timing and association with volatile organic compounds</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2020-03</date><risdate>2020</risdate><volume>182</volume><spage>108963</spage><epage>108963</epage><pages>108963-108963</pages><artnum>108963</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The current study examined symptoms of irritation reported by non-smokers passively exposed to e-cigarette aerosols and their timing and association with the concentrations of volatile organic compounds (VOCs) produced. 40 healthy non-smoking adults were exposed to e-cigarette aerosols for 30 min in a 35 m3 room. Second-hand e-cigarette aerosol (SHA) was produced by an experienced e-cigarette user using a standardized topography and two resistance settings (exposure 0.5 Ohm and 1.5 Ohm), in addition to a control session (no emissions). PM2.5 and PM1.0 were continuously measured over the duration of exposure, while Volatile Organic Compounds (VOCs) were recorded at 0, 15 and 30 min (t0, t15 and t30) of exposure. Each participant completed an irritation questionnaire at t0, t15, t30 of exposure and t60 (30 min post-exposure) on ocular, nasal, throat-respiratory symptoms of irritation and general complaints. Kruskal-Wallis H test for PM comparisons, repeated measures ANOVA for VOCs and Generalized Estimating Equations for symptoms of irritation and association with VOCs were used for statistical analysis. 20 males and 20 females, with a mean age of 24.6 years (SD = 4.3) and exhaled CO &lt; 7 ppm participated. PM concentrations in both experimental sessions were higher than the Control (p &lt; 0.001). The most commonly reported symptoms were burning, dryness, sore throat, cough, breathlessness and headache. During both experimental sessions, ocular, nasal, throat-respiratory symptoms and general complaints increased significantly (p &lt; 0.05). Ocular and nasal symptoms returned to baseline by t60 (p &gt; 0.05) while throat-respiratory symptoms were still significantly higher at t60 (p = 0.044). VOCs were significantly associated with reported nasal and throat-respiratory symptoms in both experimental sessions (p &lt; 0.05). A 30-min exposure to SHA provoked symptoms of sensory irritation and general complaints that lasted up to 30 min after the exposure and were positively associated with the concentrations of the VOC mixture emitted. •E-cigarette emits VOCs, PM1.0 and PM2.5 into the environment.•Most common sensory irritation symptoms reported were burning and itchiness.•Passive exposure to e-cigarette aerosols resulted in chemosensory irritation.•Irritation symptoms were related to VOCs concentrations produced.•Throat-respiratory irritation symptoms persisted beyond 30 min after exposure.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>31837549</pmid><doi>10.1016/j.envres.2019.108963</doi><tpages>1</tpages></addata></record>
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source ScienceDirect Freedom Collection 2022-2024
subjects e-cigarettes
Second-hand aerosol
Sensory irritation
Ultrafine particulates
Volatile organic compounds
title Passive exposure of non-smokers to E-Cigarette aerosols: Sensory irritation, timing and association with volatile organic compounds
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