Long-term changes of right ventricular myocardial deformation and remodeling studied by cardiac magnetic resonance imaging in patients with chronic thromboembolic pulmonary hypertension following pulmonary thromboendarterectomy

Right ventricular (RV) afterload in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is associated with reduced myocardial contractility and ventriculoarterial coupling. The impact of increased afterload on RV myocardial deformation was assessed by comparing the characteristics of...

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Bibliographic Details
Published in:International journal of cardiology 2020-02, Vol.300, p.282-288
Main Authors: Waziri, Farhad, Ringgaard, Steffen, Mellemkjær, Søren, Bøgh, Nikolaj, Kim, Won Yong, Clemmensen, Tor Skibsted, Hjortdal, Vibeke Elisabeth, Nielsen, Sten Lyager, Poulsen, Steen Hvitfeldt
Format: Article
Language:English
Subjects:
Aged
Cardiac magnetic resonance
Chronic Disease
Chronic thromboembolic pulmonary hypertension
Endarterectomy - trends
Female
Follow-Up Studies
Humans
Hypertension, Pulmonary - diagnostic imaging
Hypertension, Pulmonary - surgery
Magnetic Resonance Imaging, Cine - trends
Male
Middle Aged
Myocardial deformation
Myocardial strain
Prospective Studies
Pulmonary Embolism - diagnostic imaging
Pulmonary Embolism - surgery
Pulmonary thromboendarterectomy
Right ventricular failure
Time Factors
Ventricular Dysfunction, Right - diagnostic imaging
Ventricular Dysfunction, Right - surgery
Ventricular Remodeling - physiology
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Summary:Right ventricular (RV) afterload in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is associated with reduced myocardial contractility and ventriculoarterial coupling. The impact of increased afterload on RV myocardial deformation was assessed by comparing the characteristics of CTEPH patients to healthy controls at baseline, and by comparing characteristics of CTEPH patients before and 12 months after pulmonary endarterectomy (PEA). Cardiac deformation and function of CTEPH patients (n = 20) and healthy controls (n = 20) were assessed by cardiac magnetic resonance (CMR). CTEPH patients were also examined with right heart catheterization before and 12 months after PEA. PEA resulted in significant improvement of invasive hemodynamics and normalization of RV hypertrophy and right atrial, RV and left ventricular dimensions and volumes. RV ejection fraction improved from 30 ± 13% at baseline to 44 ± 10% at 12 months (p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2019.09.038