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Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study
As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well...
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| Published in: | Brain imaging and behavior 2020-12, Vol.14 (6), p.2302-2310 |
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| creator | Mao, Cui Ping Chen, Fen Rong Sun, Hong Hong Shi, Mei Juan Yang, Hua Juan Li, Xiao Hui Ding, Dun |
| description | As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS. |
| doi_str_mv | 10.1007/s11682-019-00181-w |
| format | article |
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However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-019-00181-w</identifier><identifier>PMID: 31468373</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Asymmetry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Caudate nucleus ; Cerebral cortex ; Cross-Sectional Studies ; Data acquisition ; Data processing ; Diarrhea ; Diarrhea - diagnostic imaging ; Diarrhea - pathology ; Humans ; Image processing ; Intestine ; Irritable bowel syndrome ; Irritable Bowel Syndrome - diagnostic imaging ; Irritable Bowel Syndrome - pathology ; Magnetic resonance ; Magnetic Resonance Imaging ; Medical imaging ; Morphology ; Neuroimaging ; Neurology ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Psychiatry ; Segmentation ; Surface analysis (chemical) ; Thalamus ; Thalamus - diagnostic imaging ; Thalamus - pathology ; Volumetric analysis</subject><ispartof>Brain imaging and behavior, 2020-12, Vol.14 (6), p.2302-2310</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Brain Imaging and Behavior is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-2e8810433973866a9a5b1403f2f065033a940291b9839320c51aaab26f9579063</citedby><cites>FETCH-LOGICAL-c403t-2e8810433973866a9a5b1403f2f065033a940291b9839320c51aaab26f9579063</cites><orcidid>0000-0002-1094-6102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31468373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mao, Cui Ping</creatorcontrib><creatorcontrib>Chen, Fen Rong</creatorcontrib><creatorcontrib>Sun, Hong Hong</creatorcontrib><creatorcontrib>Shi, Mei Juan</creatorcontrib><creatorcontrib>Yang, Hua Juan</creatorcontrib><creatorcontrib>Li, Xiao Hui</creatorcontrib><creatorcontrib>Ding, Dun</creatorcontrib><title>Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS.</description><subject>Asymmetry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Caudate nucleus</subject><subject>Cerebral cortex</subject><subject>Cross-Sectional Studies</subject><subject>Data acquisition</subject><subject>Data processing</subject><subject>Diarrhea</subject><subject>Diarrhea - diagnostic imaging</subject><subject>Diarrhea - pathology</subject><subject>Humans</subject><subject>Image processing</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - diagnostic imaging</subject><subject>Irritable Bowel Syndrome - pathology</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical imaging</subject><subject>Morphology</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Psychiatry</subject><subject>Segmentation</subject><subject>Surface analysis (chemical)</subject><subject>Thalamus</subject><subject>Thalamus - 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Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mao, Cui Ping</au><au>Chen, Fen Rong</au><au>Sun, Hong Hong</au><au>Shi, Mei Juan</au><au>Yang, Hua Juan</au><au>Li, Xiao Hui</au><au>Ding, Dun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>14</volume><issue>6</issue><spage>2302</spage><epage>2310</epage><pages>2302-2310</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>As a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to characterize the morphology of the thalamus and other subcortical structures. Our results suggested that the majority (31 cases) of the patients with IBS had diarrhea-predominant symptoms. Volumetric analysis revealed a larger normalized volume of the right thalamus and left caudate nucleus in patients with IBS than in healthy controls. Surface analysis indicated that the difference arose mainly from the laterodorsal nucleus of the right thalamus, and the body of the left caudate nucleus. In addition, patients with IBS had different hemispheric asymmetries of the thalamus (rightward) and caudate nucleus (leftward) from controls (leftward for the thalamus and rightward for the caudate nucleus). In general, our results indicated that patients with diarrhea-predominant IBS had enlarged thalamus and caudate nucleus volumes, as well as altered hemispheric asymmetries of these two structures, compared with healthy controls. The neuroimaging evidence of these structural alterations helps clarify the underlying pathophysiology of diarrhea-predominant IBS.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31468373</pmid><doi>10.1007/s11682-019-00181-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1094-6102</orcidid></addata></record> |
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| subjects | Asymmetry Biomedical and Life Sciences Biomedicine Brain Caudate nucleus Cerebral cortex Cross-Sectional Studies Data acquisition Data processing Diarrhea Diarrhea - diagnostic imaging Diarrhea - pathology Humans Image processing Intestine Irritable bowel syndrome Irritable Bowel Syndrome - diagnostic imaging Irritable Bowel Syndrome - pathology Magnetic resonance Magnetic Resonance Imaging Medical imaging Morphology Neuroimaging Neurology Neuropsychology Neuroradiology Neurosciences Original Research Psychiatry Segmentation Surface analysis (chemical) Thalamus Thalamus - diagnostic imaging Thalamus - pathology Volumetric analysis |
| title | Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study |
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