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Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife
To evaluate the toxicity and efficacy of re-irradiation with salvage stereotactic radiotherapy (SRT) for recurrent glioma using CyberKnife. This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2...
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| Published in: | Anticancer research 2019-06, Vol.39 (6), p.2935-2940 |
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| Main Authors: | , , , , , , , , , , , , , , , |
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| container_title | Anticancer research |
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| creator | Adachi, Kana Hayashi, Kazuhiko Kagawa, Naoki Kinoshita, Manabu Sumida, Iori Akino, Yuichi Shiomi, Hiroya Tamari, Keisuke Suzuki, Osamu Hirayama, Ryuichi Kijima, Noriyuki Isohashi, Fumiaki Seo, Yuji Otani, Keisuke Kishima, Haruhiko Ogawa, Kazuhiko |
| description | To evaluate the toxicity and efficacy of re-irradiation with salvage stereotactic radiotherapy (SRT) for recurrent glioma using CyberKnife.
This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively.
After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival.
Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma. |
| doi_str_mv | 10.21873/anticanres.13423 |
| format | article |
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This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively.
After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival.
Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.13423</identifier><identifier>PMID: 31177132</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adolescent ; Adult ; Aged ; Brain ; Brain Neoplasms - radiotherapy ; Child ; Feasibility ; Feasibility Studies ; Female ; Glioma ; Glioma - radiotherapy ; Humans ; Irradiation ; Male ; Middle Aged ; Necrosis ; Neoplasm Recurrence, Local - radiotherapy ; Prognosis ; Radiation ; Radiation Dosage ; Radiation effects ; Radiation therapy ; Radiosurgery - adverse effects ; Retrospective Studies ; Salvage ; Salvage Therapy - adverse effects ; Surgery ; Survival ; Toxicity ; Treatment Outcome ; Young Adult</subject><ispartof>Anticancer research, 2019-06, Vol.39 (6), p.2935-2940</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Jun 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-cf42589a5aebb9099f481b4653741486fa44f2d55472377f82fd4affd7135b003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31177132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Kana</creatorcontrib><creatorcontrib>Hayashi, Kazuhiko</creatorcontrib><creatorcontrib>Kagawa, Naoki</creatorcontrib><creatorcontrib>Kinoshita, Manabu</creatorcontrib><creatorcontrib>Sumida, Iori</creatorcontrib><creatorcontrib>Akino, Yuichi</creatorcontrib><creatorcontrib>Shiomi, Hiroya</creatorcontrib><creatorcontrib>Tamari, Keisuke</creatorcontrib><creatorcontrib>Suzuki, Osamu</creatorcontrib><creatorcontrib>Hirayama, Ryuichi</creatorcontrib><creatorcontrib>Kijima, Noriyuki</creatorcontrib><creatorcontrib>Isohashi, Fumiaki</creatorcontrib><creatorcontrib>Seo, Yuji</creatorcontrib><creatorcontrib>Otani, Keisuke</creatorcontrib><creatorcontrib>Kishima, Haruhiko</creatorcontrib><creatorcontrib>Ogawa, Kazuhiko</creatorcontrib><title>Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>To evaluate the toxicity and efficacy of re-irradiation with salvage stereotactic radiotherapy (SRT) for recurrent glioma using CyberKnife.
This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively.
After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival.
Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Brain</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Feasibility</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - radiotherapy</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Necrosis</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Prognosis</subject><subject>Radiation</subject><subject>Radiation Dosage</subject><subject>Radiation effects</subject><subject>Radiation therapy</subject><subject>Radiosurgery - adverse effects</subject><subject>Retrospective Studies</subject><subject>Salvage</subject><subject>Salvage Therapy - adverse effects</subject><subject>Surgery</subject><subject>Survival</subject><subject>Toxicity</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkUlLxEAQhRtRdFx-gBdp8OIl2ms6OcrghoIwo3gMlaRae8ikx-6OMP_euIOnOtT3Xi2PkEPOTgUvjDyDPrkG-oDxlEsl5AaZcFPyzGjJNsmECc0yw5jeIbsxLhjL87KQ22RHcm4Ml2JCFpcI0dWuc2lNvaVz6N7gGekMMxcCtA6S8z19cumFzhMG9AmacSidjT2fXjDAak2tD6OiGULAPtGrzvkl0Mfo-mc6XdcYbntncZ9sWegiHnzXPfJ4efEwvc7u7q9upud3WaN0nrLGKqGLEjRgXZesLK0qeK1yLY3iqsgtKGVFq7UyQhpjC2FbBda240G6ZkzukZMv31XwrwPGVC1dbLDroEc_xEoIJQophfpAj_-hCz-EftxupDQ3jOdlOVL8i2qCjzGgrVbBLSGsK86qzyCqvyCqzyBGzdG381Avsf1V_HxevgMXDYaY</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Adachi, Kana</creator><creator>Hayashi, Kazuhiko</creator><creator>Kagawa, Naoki</creator><creator>Kinoshita, Manabu</creator><creator>Sumida, Iori</creator><creator>Akino, Yuichi</creator><creator>Shiomi, Hiroya</creator><creator>Tamari, Keisuke</creator><creator>Suzuki, Osamu</creator><creator>Hirayama, Ryuichi</creator><creator>Kijima, Noriyuki</creator><creator>Isohashi, Fumiaki</creator><creator>Seo, Yuji</creator><creator>Otani, Keisuke</creator><creator>Kishima, Haruhiko</creator><creator>Ogawa, Kazuhiko</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife</title><author>Adachi, Kana ; 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This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively.
After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival.
Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>31177132</pmid><doi>10.21873/anticanres.13423</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Brain Brain Neoplasms - radiotherapy Child Feasibility Feasibility Studies Female Glioma Glioma - radiotherapy Humans Irradiation Male Middle Aged Necrosis Neoplasm Recurrence, Local - radiotherapy Prognosis Radiation Radiation Dosage Radiation effects Radiation therapy Radiosurgery - adverse effects Retrospective Studies Salvage Salvage Therapy - adverse effects Surgery Survival Toxicity Treatment Outcome Young Adult |
| title | Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife |
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