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Antimicrobial susceptibility and clinical findings of significant anaerobic bacteria in southern Spain
The objectives of this study were to report on the antimicrobial susceptibility of 276 clinically significant anaerobic bacteria belonging to the major genera isolated between May 2017 and November 2018 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients....
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| Published in: | Anaerobe 2019-10, Vol.59, p.49-53 |
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| creator | Cobo, Fernando Rodríguez-Granger, Javier Pérez-Zapata, Inés Sampedro, Antonio Aliaga, Luis Navarro-Marí, José María |
| description | The objectives of this study were to report on the antimicrobial susceptibility of 276 clinically significant anaerobic bacteria belonging to the major genera isolated between May 2017 and November 2018 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species identification was performed by MALDI-TOF MS. Antimicrobial susceptibility tests were performed against penicillin, amoxicillin-clavulanic, imipenem, meropenem, moxifloxacin, clindamycin, metronidazole, vancomycin, and piperacillin-tazobactam using the gradient diffusion technique and EUCAST breakpoints (except for moxifloxacin). The most frequent anaerobes were Bacteroides (29.7%; n = 82), Clostridioides difficile (15.9%, n = 44), Prevotella (10.8%, n = 30), and Propionibacterium (10.7%, n = 25). Metronidazole was not universally active against all genera tested, and some isolates showed resistance to this drug. Almost all tested anaerobes were susceptible to carbapenems and amoxicillin-clavulanate except for Clostridioides difficile (resistance rate of 94%) and Bacteroides (19%), respectively. High overall resistance rates to clindamycin were observed, especially for genera Finegoldia (54%), Bacteroides (49%), and Prevotella (40%). Resistance rates to carbapenems and amoxicillin-clavulanate were very low for the majority of tested genera but were high for Clostridioides difficile and Bacteroides spp., respectively. Resistance to clindamycin was very high, especially for Bacteroides, Finegoldia magna, Prevotella and Peptoniphilus. Routine antimicrobial susceptibility testing for anaerobes contributes information on the global situation and allows empirical therapies to be selected in accordance with local data on resistant strains.
•Metronidazole was not universally active against all anaerobes.•Resistance rates to carbapenems and amoxicillin-clavulanate were very low.•Resistance rates of almost all genera to clindamycin were very high.•Routine antimicrobial susceptibility testing is highly recommended. |
| doi_str_mv | 10.1016/j.anaerobe.2019.05.007 |
| format | article |
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•Metronidazole was not universally active against all anaerobes.•Resistance rates to carbapenems and amoxicillin-clavulanate were very low.•Resistance rates of almost all genera to clindamycin were very high.•Routine antimicrobial susceptibility testing is highly recommended.</description><identifier>ISSN: 1075-9964</identifier><identifier>EISSN: 1095-8274</identifier><identifier>DOI: 10.1016/j.anaerobe.2019.05.007</identifier><identifier>PMID: 31103531</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anaerobic bacteria ; Anti-Bacterial Agents - pharmacology ; Antimicrobial susceptibility ; Bacteria, Anaerobic - classification ; Bacteria, Anaerobic - drug effects ; Bacteria, Anaerobic - isolation & purification ; Bacterial Infections - epidemiology ; Bacterial Infections - microbiology ; Bacterial Infections - pathology ; Child ; Child, Preschool ; Clinical features ; Drug Resistance, Bacterial ; Female ; Humans ; Infant ; MALDI-TOF MS ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Prevalence ; Prospective Studies ; Southern Spain ; Spain - epidemiology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Tertiary Care Centers ; Young Adult</subject><ispartof>Anaerobe, 2019-10, Vol.59, p.49-53</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-9768b66dba6545fa5c6b1178c5053b7a0d72ab3e624bdc66d50b60fd8838ee363</citedby><cites>FETCH-LOGICAL-c368t-9768b66dba6545fa5c6b1178c5053b7a0d72ab3e624bdc66d50b60fd8838ee363</cites><orcidid>0000-0002-9203-9628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31103531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cobo, Fernando</creatorcontrib><creatorcontrib>Rodríguez-Granger, Javier</creatorcontrib><creatorcontrib>Pérez-Zapata, Inés</creatorcontrib><creatorcontrib>Sampedro, Antonio</creatorcontrib><creatorcontrib>Aliaga, Luis</creatorcontrib><creatorcontrib>Navarro-Marí, José María</creatorcontrib><title>Antimicrobial susceptibility and clinical findings of significant anaerobic bacteria in southern Spain</title><title>Anaerobe</title><addtitle>Anaerobe</addtitle><description>The objectives of this study were to report on the antimicrobial susceptibility of 276 clinically significant anaerobic bacteria belonging to the major genera isolated between May 2017 and November 2018 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species identification was performed by MALDI-TOF MS. Antimicrobial susceptibility tests were performed against penicillin, amoxicillin-clavulanic, imipenem, meropenem, moxifloxacin, clindamycin, metronidazole, vancomycin, and piperacillin-tazobactam using the gradient diffusion technique and EUCAST breakpoints (except for moxifloxacin). The most frequent anaerobes were Bacteroides (29.7%; n = 82), Clostridioides difficile (15.9%, n = 44), Prevotella (10.8%, n = 30), and Propionibacterium (10.7%, n = 25). Metronidazole was not universally active against all genera tested, and some isolates showed resistance to this drug. Almost all tested anaerobes were susceptible to carbapenems and amoxicillin-clavulanate except for Clostridioides difficile (resistance rate of 94%) and Bacteroides (19%), respectively. High overall resistance rates to clindamycin were observed, especially for genera Finegoldia (54%), Bacteroides (49%), and Prevotella (40%). Resistance rates to carbapenems and amoxicillin-clavulanate were very low for the majority of tested genera but were high for Clostridioides difficile and Bacteroides spp., respectively. Resistance to clindamycin was very high, especially for Bacteroides, Finegoldia magna, Prevotella and Peptoniphilus. Routine antimicrobial susceptibility testing for anaerobes contributes information on the global situation and allows empirical therapies to be selected in accordance with local data on resistant strains.
•Metronidazole was not universally active against all anaerobes.•Resistance rates to carbapenems and amoxicillin-clavulanate were very low.•Resistance rates of almost all genera to clindamycin were very high.•Routine antimicrobial susceptibility testing is highly recommended.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anaerobic bacteria</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial susceptibility</subject><subject>Bacteria, Anaerobic - classification</subject><subject>Bacteria, Anaerobic - drug effects</subject><subject>Bacteria, Anaerobic - isolation & purification</subject><subject>Bacterial Infections - epidemiology</subject><subject>Bacterial Infections - microbiology</subject><subject>Bacterial Infections - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical features</subject><subject>Drug Resistance, Bacterial</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>MALDI-TOF MS</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Southern Spain</subject><subject>Spain - epidemiology</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Tertiary Care Centers</subject><subject>Young Adult</subject><issn>1075-9964</issn><issn>1095-8274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkEtv1DAURi0Eog_4C5WXbBKu49hJdlQVBaRKXQBry4-bckcZZ7AdpP57PJopW1a27HMf32HsRkArQOiPu9ZGi2l12HYgphZUCzC8YpcCJtWM3dC_Pt4H1UyT7i_YVc47ACF6pd6yCykESCXFJZtvY6E9-dqJ7MLzlj0eCjlaqDxzGwP3C0Xy9W-mGCg-Zb7OPNNTpLk-x8LPi5DnzvqCiSynyPO6lV-YIv9-sBTfsTezXTK-P5_X7Of95x93X5uHxy_f7m4fGi_1WJpp0KPTOjirVa9mq7x2QgyjV6CkGyyEobNOou56F3wFFTgNcxhHOSJKLa_Zh1PfQ1p_b5iL2VNNtCw24rpl03WyAz2KASqqT2jNnnPC2RwS7W16NgLM0bHZmRfH5ujYgDLVcS28Oc_Y3B7Dv7IXqRX4dAKwJv1DmEz2hNFjoIS-mLDS_2b8BRZpknE</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Cobo, Fernando</creator><creator>Rodríguez-Granger, Javier</creator><creator>Pérez-Zapata, Inés</creator><creator>Sampedro, Antonio</creator><creator>Aliaga, Luis</creator><creator>Navarro-Marí, José María</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9203-9628</orcidid></search><sort><creationdate>201910</creationdate><title>Antimicrobial susceptibility and clinical findings of significant anaerobic bacteria in southern Spain</title><author>Cobo, Fernando ; Rodríguez-Granger, Javier ; Pérez-Zapata, Inés ; Sampedro, Antonio ; Aliaga, Luis ; Navarro-Marí, José María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-9768b66dba6545fa5c6b1178c5053b7a0d72ab3e624bdc66d50b60fd8838ee363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anaerobic bacteria</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial susceptibility</topic><topic>Bacteria, Anaerobic - classification</topic><topic>Bacteria, Anaerobic - drug effects</topic><topic>Bacteria, Anaerobic - isolation & purification</topic><topic>Bacterial Infections - epidemiology</topic><topic>Bacterial Infections - microbiology</topic><topic>Bacterial Infections - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical features</topic><topic>Drug Resistance, Bacterial</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>MALDI-TOF MS</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Southern Spain</topic><topic>Spain - epidemiology</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Tertiary Care Centers</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cobo, Fernando</creatorcontrib><creatorcontrib>Rodríguez-Granger, Javier</creatorcontrib><creatorcontrib>Pérez-Zapata, Inés</creatorcontrib><creatorcontrib>Sampedro, Antonio</creatorcontrib><creatorcontrib>Aliaga, Luis</creatorcontrib><creatorcontrib>Navarro-Marí, José María</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaerobe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cobo, Fernando</au><au>Rodríguez-Granger, Javier</au><au>Pérez-Zapata, Inés</au><au>Sampedro, Antonio</au><au>Aliaga, Luis</au><au>Navarro-Marí, José María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial susceptibility and clinical findings of significant anaerobic bacteria in southern Spain</atitle><jtitle>Anaerobe</jtitle><addtitle>Anaerobe</addtitle><date>2019-10</date><risdate>2019</risdate><volume>59</volume><spage>49</spage><epage>53</epage><pages>49-53</pages><issn>1075-9964</issn><eissn>1095-8274</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The objectives of this study were to report on the antimicrobial susceptibility of 276 clinically significant anaerobic bacteria belonging to the major genera isolated between May 2017 and November 2018 in a tertiary hospital in Granada (Spain) and to describe key clinical features of the patients. Species identification was performed by MALDI-TOF MS. Antimicrobial susceptibility tests were performed against penicillin, amoxicillin-clavulanic, imipenem, meropenem, moxifloxacin, clindamycin, metronidazole, vancomycin, and piperacillin-tazobactam using the gradient diffusion technique and EUCAST breakpoints (except for moxifloxacin). The most frequent anaerobes were Bacteroides (29.7%; n = 82), Clostridioides difficile (15.9%, n = 44), Prevotella (10.8%, n = 30), and Propionibacterium (10.7%, n = 25). Metronidazole was not universally active against all genera tested, and some isolates showed resistance to this drug. Almost all tested anaerobes were susceptible to carbapenems and amoxicillin-clavulanate except for Clostridioides difficile (resistance rate of 94%) and Bacteroides (19%), respectively. High overall resistance rates to clindamycin were observed, especially for genera Finegoldia (54%), Bacteroides (49%), and Prevotella (40%). Resistance rates to carbapenems and amoxicillin-clavulanate were very low for the majority of tested genera but were high for Clostridioides difficile and Bacteroides spp., respectively. Resistance to clindamycin was very high, especially for Bacteroides, Finegoldia magna, Prevotella and Peptoniphilus. Routine antimicrobial susceptibility testing for anaerobes contributes information on the global situation and allows empirical therapies to be selected in accordance with local data on resistant strains.
•Metronidazole was not universally active against all anaerobes.•Resistance rates to carbapenems and amoxicillin-clavulanate were very low.•Resistance rates of almost all genera to clindamycin were very high.•Routine antimicrobial susceptibility testing is highly recommended.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31103531</pmid><doi>10.1016/j.anaerobe.2019.05.007</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9203-9628</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anaerobic bacteria Anti-Bacterial Agents - pharmacology Antimicrobial susceptibility Bacteria, Anaerobic - classification Bacteria, Anaerobic - drug effects Bacteria, Anaerobic - isolation & purification Bacterial Infections - epidemiology Bacterial Infections - microbiology Bacterial Infections - pathology Child Child, Preschool Clinical features Drug Resistance, Bacterial Female Humans Infant MALDI-TOF MS Male Microbial Sensitivity Tests Middle Aged Prevalence Prospective Studies Southern Spain Spain - epidemiology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tertiary Care Centers Young Adult |
| title | Antimicrobial susceptibility and clinical findings of significant anaerobic bacteria in southern Spain |
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