Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility

To investigate the paternal mitochondrial DNA’s effect on assisted reproductive technology (ART) applications and possible paternal mitochondrial DNA transmission in male factor infertility diagnosed fathers. Study group was designed according to the families all of which applied to assisted reprodu...

Full description

Saved in:
Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2019-05, Vol.236, p.183-192
Main Authors: Eker, Candan, Celik, Hale Goksever, Balci, Burcin Karamustafaoglu, Gunel, Tuba
Format: Article
Language:English
Subjects:
mtDNA transmission
Next generation sequencing
Paternal mitochondria
Paternal mitochondrial inheritance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53
cites cdi_FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53
container_end_page 192
container_issue
container_start_page 183
container_title European journal of obstetrics & gynecology and reproductive biology
container_volume 236
creator Eker, Candan
Celik, Hale Goksever
Balci, Burcin Karamustafaoglu
Gunel, Tuba
description To investigate the paternal mitochondrial DNA’s effect on assisted reproductive technology (ART) applications and possible paternal mitochondrial DNA transmission in male factor infertility diagnosed fathers. Study group was designed according to the families all of which applied to assisted reproductive technologies as a result of male infertility. A total of 16 trios (48 mother-father-child samples) which contain 7 newborns and 9 infants born by in vitro fertilization method (IVF-ICSI) were studied using “Illumina, MiSeq” next-generation sequencing platform (Case-parent trio study). The study has been conducted between February 2017 and May 2018. Sequencing analysis results were investigated on the basis of “mother-father-child”, “mother-child” and “father-child” mitochondrial DNA whole genome sequence data, respectively. In 14 “trios” of 16; maternal mitochondrial DNA haplotype were detected for children, the remaining 2 “trios” had different mitochondrial DNA haplotypes when compared to their mother and fathers. Also; “father-child” sharing same genetic variants (SNP (“Single nucleotide polymorphism”) / MNP (“Multiple nucleotide polymorphism”) / INDEL (“Insertion/Deletion”) were found in 8 “trios”. In 5 “trios” of 16; 98–99% paternal mitochondrial DNA genome sequence similarity were obtained by alignment of “father-child” mitochondrial DNA genome. This study is the first whole mitochondrial genome investigation for paternal mitochondrial DNA contribution in human IVF / ICSI applied trio cases. Our findings for paternally derived variants could be the result of intermolecular recombination between maternal and paternal mitochondrial DNA.
doi_str_mv 10.1016/j.ejogrb.2019.02.011
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2205410058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301211519300788</els_id><sourcerecordid>2205410058</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EokvhHyDkI5cEfybZC9Kq5aNSBRIqZ2vijBuvEnuxvUX993i1hSNzsUZ63hnPQ8hbzlrOePdh3-I-3qexFYxvWyZaxvkzsuFDL5q-0-o52TDJeCM41xfkVc57VkvK7UtyIdlWq57rDTnchAfMxd9D8THQ6Oh8XCHQAxRMARa6-hLtHMOUfO2uv-1oSRDy6nM-BXygux93dITRY6a_55iROigzptr5MtMVFqyUw1T84svja_LCwZLxzdN7SX5-_nR39bW5_f7l5mp321jZidJMekBhR6fsAAIYdKCEG-UgdTf1UrNeCanFyHro1aAncIwrzrmTA2i1BS0vyfvz3EOKv471RFO_bHFZIGA8ZiME04ozpoeKqjNqU8w5oTOH5FdIj4Yzc3Jt9ubs2pxcGyZMdV1j7542HMcVp3-hv3Ir8PEMYL3zwWMy2XoMFief0BYzRf__DX8AayeSjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2205410058</pqid></control><display><type>article</type><title>Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility</title><source>ScienceDirect Journals</source><creator>Eker, Candan ; Celik, Hale Goksever ; Balci, Burcin Karamustafaoglu ; Gunel, Tuba</creator><creatorcontrib>Eker, Candan ; Celik, Hale Goksever ; Balci, Burcin Karamustafaoglu ; Gunel, Tuba</creatorcontrib><description>To investigate the paternal mitochondrial DNA’s effect on assisted reproductive technology (ART) applications and possible paternal mitochondrial DNA transmission in male factor infertility diagnosed fathers. Study group was designed according to the families all of which applied to assisted reproductive technologies as a result of male infertility. A total of 16 trios (48 mother-father-child samples) which contain 7 newborns and 9 infants born by in vitro fertilization method (IVF-ICSI) were studied using “Illumina, MiSeq” next-generation sequencing platform (Case-parent trio study). The study has been conducted between February 2017 and May 2018. Sequencing analysis results were investigated on the basis of “mother-father-child”, “mother-child” and “father-child” mitochondrial DNA whole genome sequence data, respectively. In 14 “trios” of 16; maternal mitochondrial DNA haplotype were detected for children, the remaining 2 “trios” had different mitochondrial DNA haplotypes when compared to their mother and fathers. Also; “father-child” sharing same genetic variants (SNP (“Single nucleotide polymorphism”) / MNP (“Multiple nucleotide polymorphism”) / INDEL (“Insertion/Deletion”) were found in 8 “trios”. In 5 “trios” of 16; 98–99% paternal mitochondrial DNA genome sequence similarity were obtained by alignment of “father-child” mitochondrial DNA genome. This study is the first whole mitochondrial genome investigation for paternal mitochondrial DNA contribution in human IVF / ICSI applied trio cases. Our findings for paternally derived variants could be the result of intermolecular recombination between maternal and paternal mitochondrial DNA.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2019.02.011</identifier><identifier>PMID: 30954715</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>mtDNA transmission ; Next generation sequencing ; Paternal mitochondria ; Paternal mitochondrial inheritance</subject><ispartof>European journal of obstetrics &amp; gynecology and reproductive biology, 2019-05, Vol.236, p.183-192</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53</citedby><cites>FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30954715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eker, Candan</creatorcontrib><creatorcontrib>Celik, Hale Goksever</creatorcontrib><creatorcontrib>Balci, Burcin Karamustafaoglu</creatorcontrib><creatorcontrib>Gunel, Tuba</creatorcontrib><title>Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility</title><title>European journal of obstetrics &amp; gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>To investigate the paternal mitochondrial DNA’s effect on assisted reproductive technology (ART) applications and possible paternal mitochondrial DNA transmission in male factor infertility diagnosed fathers. Study group was designed according to the families all of which applied to assisted reproductive technologies as a result of male infertility. A total of 16 trios (48 mother-father-child samples) which contain 7 newborns and 9 infants born by in vitro fertilization method (IVF-ICSI) were studied using “Illumina, MiSeq” next-generation sequencing platform (Case-parent trio study). The study has been conducted between February 2017 and May 2018. Sequencing analysis results were investigated on the basis of “mother-father-child”, “mother-child” and “father-child” mitochondrial DNA whole genome sequence data, respectively. In 14 “trios” of 16; maternal mitochondrial DNA haplotype were detected for children, the remaining 2 “trios” had different mitochondrial DNA haplotypes when compared to their mother and fathers. Also; “father-child” sharing same genetic variants (SNP (“Single nucleotide polymorphism”) / MNP (“Multiple nucleotide polymorphism”) / INDEL (“Insertion/Deletion”) were found in 8 “trios”. In 5 “trios” of 16; 98–99% paternal mitochondrial DNA genome sequence similarity were obtained by alignment of “father-child” mitochondrial DNA genome. This study is the first whole mitochondrial genome investigation for paternal mitochondrial DNA contribution in human IVF / ICSI applied trio cases. Our findings for paternally derived variants could be the result of intermolecular recombination between maternal and paternal mitochondrial DNA.</description><subject>mtDNA transmission</subject><subject>Next generation sequencing</subject><subject>Paternal mitochondria</subject><subject>Paternal mitochondrial inheritance</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EokvhHyDkI5cEfybZC9Kq5aNSBRIqZ2vijBuvEnuxvUX993i1hSNzsUZ63hnPQ8hbzlrOePdh3-I-3qexFYxvWyZaxvkzsuFDL5q-0-o52TDJeCM41xfkVc57VkvK7UtyIdlWq57rDTnchAfMxd9D8THQ6Oh8XCHQAxRMARa6-hLtHMOUfO2uv-1oSRDy6nM-BXygux93dITRY6a_55iROigzptr5MtMVFqyUw1T84svja_LCwZLxzdN7SX5-_nR39bW5_f7l5mp321jZidJMekBhR6fsAAIYdKCEG-UgdTf1UrNeCanFyHro1aAncIwrzrmTA2i1BS0vyfvz3EOKv471RFO_bHFZIGA8ZiME04ozpoeKqjNqU8w5oTOH5FdIj4Yzc3Jt9ubs2pxcGyZMdV1j7542HMcVp3-hv3Ir8PEMYL3zwWMy2XoMFief0BYzRf__DX8AayeSjw</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Eker, Candan</creator><creator>Celik, Hale Goksever</creator><creator>Balci, Burcin Karamustafaoglu</creator><creator>Gunel, Tuba</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility</title><author>Eker, Candan ; Celik, Hale Goksever ; Balci, Burcin Karamustafaoglu ; Gunel, Tuba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>mtDNA transmission</topic><topic>Next generation sequencing</topic><topic>Paternal mitochondria</topic><topic>Paternal mitochondrial inheritance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eker, Candan</creatorcontrib><creatorcontrib>Celik, Hale Goksever</creatorcontrib><creatorcontrib>Balci, Burcin Karamustafaoglu</creatorcontrib><creatorcontrib>Gunel, Tuba</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eker, Candan</au><au>Celik, Hale Goksever</au><au>Balci, Burcin Karamustafaoglu</au><au>Gunel, Tuba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility</atitle><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>236</volume><spage>183</spage><epage>192</epage><pages>183-192</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>To investigate the paternal mitochondrial DNA’s effect on assisted reproductive technology (ART) applications and possible paternal mitochondrial DNA transmission in male factor infertility diagnosed fathers. Study group was designed according to the families all of which applied to assisted reproductive technologies as a result of male infertility. A total of 16 trios (48 mother-father-child samples) which contain 7 newborns and 9 infants born by in vitro fertilization method (IVF-ICSI) were studied using “Illumina, MiSeq” next-generation sequencing platform (Case-parent trio study). The study has been conducted between February 2017 and May 2018. Sequencing analysis results were investigated on the basis of “mother-father-child”, “mother-child” and “father-child” mitochondrial DNA whole genome sequence data, respectively. In 14 “trios” of 16; maternal mitochondrial DNA haplotype were detected for children, the remaining 2 “trios” had different mitochondrial DNA haplotypes when compared to their mother and fathers. Also; “father-child” sharing same genetic variants (SNP (“Single nucleotide polymorphism”) / MNP (“Multiple nucleotide polymorphism”) / INDEL (“Insertion/Deletion”) were found in 8 “trios”. In 5 “trios” of 16; 98–99% paternal mitochondrial DNA genome sequence similarity were obtained by alignment of “father-child” mitochondrial DNA genome. This study is the first whole mitochondrial genome investigation for paternal mitochondrial DNA contribution in human IVF / ICSI applied trio cases. Our findings for paternally derived variants could be the result of intermolecular recombination between maternal and paternal mitochondrial DNA.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30954715</pmid><doi>10.1016/j.ejogrb.2019.02.011</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0301-2115
ispartof European journal of obstetrics & gynecology and reproductive biology, 2019-05, Vol.236, p.183-192
issn 0301-2115
1872-7654
language eng
recordid cdi_proquest_miscellaneous_2205410058
source ScienceDirect Journals
subjects mtDNA transmission
Next generation sequencing
Paternal mitochondria
Paternal mitochondrial inheritance
title Investigation of human paternal mitochondrial DNA transmission in ART babies whose fathers with male infertility
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T21%3A26%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20human%20paternal%20mitochondrial%20DNA%20transmission%20in%20ART%20babies%20whose%20fathers%20with%20male%20infertility&rft.jtitle=European%20journal%20of%20obstetrics%20&%20gynecology%20and%20reproductive%20biology&rft.au=Eker,%20Candan&rft.date=2019-05-01&rft.volume=236&rft.spage=183&rft.epage=192&rft.pages=183-192&rft.issn=0301-2115&rft.eissn=1872-7654&rft_id=info:doi/10.1016/j.ejogrb.2019.02.011&rft_dat=%3Cproquest_cross%3E2205410058%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c362t-d58e2cbf4c8a2a0a6a42fb38356d7350742352b07a7485daf014111f38a549a53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2205410058&rft_id=info:pmid/30954715&rfr_iscdi=true