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Thrombophilia in non‐thrombotic chronic venous disease of the lower limb – a systematic review
Summary Chronic venous disease (CVD) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post‐thrombotic CVD. A systematic review was performed to determine the relationship between thrombophilia and non‐thrombotic CVD. MEDLINE® and Embase® databa...
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| Published in: | British journal of haematology 2018-12, Vol.183 (5), p.703-716 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 716 |
| container_issue | 5 |
| container_start_page | 703 |
| container_title | British journal of haematology |
| container_volume | 183 |
| creator | Tan, Matthew K. H. Onida, Sarah Laffan, Michael Davies, Alun H. |
| description | Summary
Chronic venous disease (CVD) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post‐thrombotic CVD. A systematic review was performed to determine the relationship between thrombophilia and non‐thrombotic CVD. MEDLINE® and Embase® databases were searched from 1946 up to March 2018. Case‐control studies, cohort studies or randomised clinical trials reporting on thrombophilias in non‐thrombotic lower limb CVD in adult patients were included. Non‐English and post‐thrombotic syndrome studies were excluded. Study selection and data extraction were performed by two reviewers. Fifteen studies were included, reporting on 916 cases and 1261 controls. Studies largely focused on venous ulceration and investigated multiple haemostatic factors. An association between thrombophilia and non‐thrombotic CVD was identified, with greater prevalence and factor concentration alteration reported in patients compared to controls. Concomitant thrombophilia presence was associated with earlier CVD onset. Relationship strength varied, with commoner aetiologies showing clearer correlation than rarer ones. Thrombophilia is associated with non‐thrombotic CVD but the mechanism is unclear and causation cannot be determined. Future research should focus on prospective studies with larger populations and identify adjunct therapies targeting thrombophilia. |
| doi_str_mv | 10.1111/bjh.15692 |
| format | article |
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Chronic venous disease (CVD) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post‐thrombotic CVD. A systematic review was performed to determine the relationship between thrombophilia and non‐thrombotic CVD. MEDLINE® and Embase® databases were searched from 1946 up to March 2018. Case‐control studies, cohort studies or randomised clinical trials reporting on thrombophilias in non‐thrombotic lower limb CVD in adult patients were included. Non‐English and post‐thrombotic syndrome studies were excluded. Study selection and data extraction were performed by two reviewers. Fifteen studies were included, reporting on 916 cases and 1261 controls. Studies largely focused on venous ulceration and investigated multiple haemostatic factors. An association between thrombophilia and non‐thrombotic CVD was identified, with greater prevalence and factor concentration alteration reported in patients compared to controls. Concomitant thrombophilia presence was associated with earlier CVD onset. Relationship strength varied, with commoner aetiologies showing clearer correlation than rarer ones. Thrombophilia is associated with non‐thrombotic CVD but the mechanism is unclear and causation cannot be determined. Future research should focus on prospective studies with larger populations and identify adjunct therapies targeting thrombophilia.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.15692</identifier><identifier>PMID: 30488425</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies - blood ; Antithrombins - metabolism ; Blood Coagulation Factors - metabolism ; Causation ; Chronic Disease ; Clinical trials ; Female ; Fibrinolysis - physiology ; Hematology ; Humans ; Hyperhomocysteinemia - complications ; Lower Extremity - blood supply ; Lupus Coagulation Inhibitor - immunology ; Male ; Middle Aged ; Mutation - genetics ; Population studies ; Prothrombin - genetics ; Risk Factors ; Systematic review ; Thrombophilia ; Thrombophilia - complications ; varicose ulcer ; Varicose Ulcer - etiology ; varicose veins ; Vascular Diseases - etiology ; Veins ; venous insufficiency ; Young Adult</subject><ispartof>British journal of haematology, 2018-12, Vol.183 (5), p.703-716</ispartof><rights>2018 British Society for Haematology and John Wiley & Sons Ltd</rights><rights>2018 British Society for Haematology and John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-7d34fede4f2d768df213a9c872da567ee8c5fa3f9b1244749ac7d1188d3aaead3</citedby><cites>FETCH-LOGICAL-c3882-7d34fede4f2d768df213a9c872da567ee8c5fa3f9b1244749ac7d1188d3aaead3</cites><orcidid>0000-0002-5789-0353</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30488425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Matthew K. H.</creatorcontrib><creatorcontrib>Onida, Sarah</creatorcontrib><creatorcontrib>Laffan, Michael</creatorcontrib><creatorcontrib>Davies, Alun H.</creatorcontrib><title>Thrombophilia in non‐thrombotic chronic venous disease of the lower limb – a systematic review</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Chronic venous disease (CVD) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post‐thrombotic CVD. A systematic review was performed to determine the relationship between thrombophilia and non‐thrombotic CVD. MEDLINE® and Embase® databases were searched from 1946 up to March 2018. Case‐control studies, cohort studies or randomised clinical trials reporting on thrombophilias in non‐thrombotic lower limb CVD in adult patients were included. Non‐English and post‐thrombotic syndrome studies were excluded. Study selection and data extraction were performed by two reviewers. Fifteen studies were included, reporting on 916 cases and 1261 controls. Studies largely focused on venous ulceration and investigated multiple haemostatic factors. An association between thrombophilia and non‐thrombotic CVD was identified, with greater prevalence and factor concentration alteration reported in patients compared to controls. Concomitant thrombophilia presence was associated with earlier CVD onset. Relationship strength varied, with commoner aetiologies showing clearer correlation than rarer ones. Thrombophilia is associated with non‐thrombotic CVD but the mechanism is unclear and causation cannot be determined. Future research should focus on prospective studies with larger populations and identify adjunct therapies targeting thrombophilia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies - blood</subject><subject>Antithrombins - metabolism</subject><subject>Blood Coagulation Factors - metabolism</subject><subject>Causation</subject><subject>Chronic Disease</subject><subject>Clinical trials</subject><subject>Female</subject><subject>Fibrinolysis - physiology</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - complications</subject><subject>Lower Extremity - blood supply</subject><subject>Lupus Coagulation Inhibitor - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Population studies</subject><subject>Prothrombin - genetics</subject><subject>Risk Factors</subject><subject>Systematic review</subject><subject>Thrombophilia</subject><subject>Thrombophilia - complications</subject><subject>varicose ulcer</subject><subject>Varicose Ulcer - etiology</subject><subject>varicose veins</subject><subject>Vascular Diseases - etiology</subject><subject>Veins</subject><subject>venous insufficiency</subject><subject>Young Adult</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Kw0AQxxdRbK0efAFZ8KKHtPuVZHNU8ZOCl3oOm-yEbkmydTe19OYjCL6hT-LWqAfBucww_ObH8EfomJIxDTUpFvMxjZOM7aAh5UkcMSroLhoSQtKIEiEH6MD7BSGUk5juowEPOylYPETFbO5sU9jl3NRGYdPi1rYfr29dv-5MicswtqG_QGtXHmvjQXnAtsLdHHBt1-BwbZoCf7y-Y4X9xnfQqO2lgxcD60O0V6naw9F3H6Gnm-vZ1V00fby9v7qYRiWXkkWp5qICDaJiOk2krhjlKitlyrSKkxRAlnGleJUVlAmRikyVqaZUSs2VAqX5CJ313qWzzyvwXd4YX0JdqxbC43nwZUHEYxbQ0z_owq5cG77bUlImKYtFoM57qnTWewdVvnSmUW6TU5Jvg89D8PlX8IE9-Tauigb0L_mTdAAmPbA2NWz-N-WXD3e98hOsL48x</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Tan, Matthew K. H.</creator><creator>Onida, Sarah</creator><creator>Laffan, Michael</creator><creator>Davies, Alun H.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5789-0353</orcidid></search><sort><creationdate>201812</creationdate><title>Thrombophilia in non‐thrombotic chronic venous disease of the lower limb – a systematic review</title><author>Tan, Matthew K. H. ; Onida, Sarah ; Laffan, Michael ; Davies, Alun H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-7d34fede4f2d768df213a9c872da567ee8c5fa3f9b1244749ac7d1188d3aaead3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies - blood</topic><topic>Antithrombins - metabolism</topic><topic>Blood Coagulation Factors - metabolism</topic><topic>Causation</topic><topic>Chronic Disease</topic><topic>Clinical trials</topic><topic>Female</topic><topic>Fibrinolysis - physiology</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - complications</topic><topic>Lower Extremity - blood supply</topic><topic>Lupus Coagulation Inhibitor - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Population studies</topic><topic>Prothrombin - genetics</topic><topic>Risk Factors</topic><topic>Systematic review</topic><topic>Thrombophilia</topic><topic>Thrombophilia - complications</topic><topic>varicose ulcer</topic><topic>Varicose Ulcer - etiology</topic><topic>varicose veins</topic><topic>Vascular Diseases - etiology</topic><topic>Veins</topic><topic>venous insufficiency</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Matthew K. H.</creatorcontrib><creatorcontrib>Onida, Sarah</creatorcontrib><creatorcontrib>Laffan, Michael</creatorcontrib><creatorcontrib>Davies, Alun H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Matthew K. H.</au><au>Onida, Sarah</au><au>Laffan, Michael</au><au>Davies, Alun H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombophilia in non‐thrombotic chronic venous disease of the lower limb – a systematic review</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>183</volume><issue>5</issue><spage>703</spage><epage>716</epage><pages>703-716</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
Chronic venous disease (CVD) represents a significant healthcare burden. Thrombophilia is proposed as a risk factor, particularly for post‐thrombotic CVD. A systematic review was performed to determine the relationship between thrombophilia and non‐thrombotic CVD. MEDLINE® and Embase® databases were searched from 1946 up to March 2018. Case‐control studies, cohort studies or randomised clinical trials reporting on thrombophilias in non‐thrombotic lower limb CVD in adult patients were included. Non‐English and post‐thrombotic syndrome studies were excluded. Study selection and data extraction were performed by two reviewers. Fifteen studies were included, reporting on 916 cases and 1261 controls. Studies largely focused on venous ulceration and investigated multiple haemostatic factors. An association between thrombophilia and non‐thrombotic CVD was identified, with greater prevalence and factor concentration alteration reported in patients compared to controls. Concomitant thrombophilia presence was associated with earlier CVD onset. Relationship strength varied, with commoner aetiologies showing clearer correlation than rarer ones. Thrombophilia is associated with non‐thrombotic CVD but the mechanism is unclear and causation cannot be determined. Future research should focus on prospective studies with larger populations and identify adjunct therapies targeting thrombophilia.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30488425</pmid><doi>10.1111/bjh.15692</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-5789-0353</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 2018-12, Vol.183 (5), p.703-716 |
| issn | 0007-1048 1365-2141 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Antibodies - blood Antithrombins - metabolism Blood Coagulation Factors - metabolism Causation Chronic Disease Clinical trials Female Fibrinolysis - physiology Hematology Humans Hyperhomocysteinemia - complications Lower Extremity - blood supply Lupus Coagulation Inhibitor - immunology Male Middle Aged Mutation - genetics Population studies Prothrombin - genetics Risk Factors Systematic review Thrombophilia Thrombophilia - complications varicose ulcer Varicose Ulcer - etiology varicose veins Vascular Diseases - etiology Veins venous insufficiency Young Adult |
| title | Thrombophilia in non‐thrombotic chronic venous disease of the lower limb – a systematic review |
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