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Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome
Objective The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS). Methods We recruited adult SLE and pSS patients and two groups of age-...
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| Published in: | Lupus 2019-01, Vol.28 (1), p.27-33 |
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| creator | Pereira e Silva, R Romão, V C Neves, M Garcia, R Oliveira, S Brites, J Ramos, F Oliveira Canhão, H Palma dos Reis, J Pereira da Silva, J A Lopes, T |
| description | Objective
The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).
Methods
We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. We compared the OABq-SF scores for SB and HRQL between patients and controls using univariate and multivariate linear regression analysis.
Results
We recruited 95 rheumatic patients (68 SLE, 27 pSS) and 231 controls. Compared to controls SLE patients showed higher OABq-SF SB scores (22.6 ± 20.4 vs 14.7 ± 17.0, p = 0.004) and lower HRQL scores (89.8 ± 15.8 vs 93.8 ± 11.4, p = 0.044). On multivariate analysis SLE was significantly associated with a higher SB score (ß-coefficient 7.13, p = 0.008) and tended to be associated with worse HRQL values (ß-coefficient –3.53, p = 0.055). Patients with pSS had numerically higher mean SB scores (22.8 ± 22.5 vs 16.2 ± 18.0, respectively, p = 0.107) and lower HRQL scores (91.0 ± 10.7 vs 93.2 ± 11.6, respectively, p = 0.369), although these differences were not statistically significant. Diagnosis of pSS was not significantly associated with SB or HRQL scores on univariate or multivariate analysis.
Conclusions
Patients with SLE have significantly worse OAB-SB and poorer HRQL compared to controls. A similar trend was seen for pSS patients, especially for SB. These findings suggest that clinically subtle OAB symptoms may be present in rheumatic patients for whom, later on, bladder pain syndrome may occur. |
| doi_str_mv | 10.1177/0961203318811605 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2132729358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203318811605</sage_id><sourcerecordid>2132729358</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-3c9792730285ea7cb0efca2f2a12b97d521dbe334bb8c9779b0cc0d30292dd4a3</originalsourceid><addsrcrecordid>eNp1kctO3DAUhi1UBFPKnlVlqRs2Kb4k43hZoZYiIbGgXUe-nDAeOXGwHdC8RZ-mL8CL4dFMqYTEyjo-3_8dWwehM0q-UirEBZFLygjntG0pXZLmAC1oLURV7tkHtNi2q23_GH1MaU0I4VQuj9AxJzWVQvAF-nP7CFGZ7B4Ba6-shYjTZphyGLAOeVVKNVq8AuXzqorgVQaLH2blXd7g0GPvesBuxJPKDsac8JPLq6JIGQZnsJ-nOWGIm6IaVA6pVFvhFN2g4gbfrZ__3kcYS2K0MQzwCR32yic43Z8n6PeP778uf1Y3t1fXl99uKlMTkStupJBMcMLaBpQwmkBvFOuZokxLYRtGrQbOa63bggqpiTHEFl4ya2vFT9D5zjvF8DBDyt3gkgHv1QhhTh2jnAkmedMW9MsbdB3mOJbXFaqRTUN5IwpFdpSJIaUIfbf_Y0dJt91W93ZbJfJ5L571APY18G89Bah2QFL38H_qu8IXLBKf5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2159551357</pqid></control><display><type>article</type><title>Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome</title><source>Sage Journals Online</source><creator>Pereira e Silva, R ; Romão, V C ; Neves, M ; Garcia, R ; Oliveira, S ; Brites, J ; Ramos, F Oliveira ; Canhão, H ; Palma dos Reis, J ; Pereira da Silva, J A ; Lopes, T</creator><creatorcontrib>Pereira e Silva, R ; Romão, V C ; Neves, M ; Garcia, R ; Oliveira, S ; Brites, J ; Ramos, F Oliveira ; Canhão, H ; Palma dos Reis, J ; Pereira da Silva, J A ; Lopes, T</creatorcontrib><description>Objective
The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).
Methods
We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. We compared the OABq-SF scores for SB and HRQL between patients and controls using univariate and multivariate linear regression analysis.
Results
We recruited 95 rheumatic patients (68 SLE, 27 pSS) and 231 controls. Compared to controls SLE patients showed higher OABq-SF SB scores (22.6 ± 20.4 vs 14.7 ± 17.0, p = 0.004) and lower HRQL scores (89.8 ± 15.8 vs 93.8 ± 11.4, p = 0.044). On multivariate analysis SLE was significantly associated with a higher SB score (ß-coefficient 7.13, p = 0.008) and tended to be associated with worse HRQL values (ß-coefficient –3.53, p = 0.055). Patients with pSS had numerically higher mean SB scores (22.8 ± 22.5 vs 16.2 ± 18.0, respectively, p = 0.107) and lower HRQL scores (91.0 ± 10.7 vs 93.2 ± 11.6, respectively, p = 0.369), although these differences were not statistically significant. Diagnosis of pSS was not significantly associated with SB or HRQL scores on univariate or multivariate analysis.
Conclusions
Patients with SLE have significantly worse OAB-SB and poorer HRQL compared to controls. A similar trend was seen for pSS patients, especially for SB. These findings suggest that clinically subtle OAB symptoms may be present in rheumatic patients for whom, later on, bladder pain syndrome may occur.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203318811605</identifier><identifier>PMID: 30419773</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Bladder ; Lupus ; Multivariate analysis ; Pain ; Quality of life ; Sjogren's syndrome ; Statistical analysis ; Systemic lupus erythematosus</subject><ispartof>Lupus, 2019-01, Vol.28 (1), p.27-33</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-3c9792730285ea7cb0efca2f2a12b97d521dbe334bb8c9779b0cc0d30292dd4a3</citedby><cites>FETCH-LOGICAL-c407t-3c9792730285ea7cb0efca2f2a12b97d521dbe334bb8c9779b0cc0d30292dd4a3</cites><orcidid>0000-0002-4396-4921</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30419773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira e Silva, R</creatorcontrib><creatorcontrib>Romão, V C</creatorcontrib><creatorcontrib>Neves, M</creatorcontrib><creatorcontrib>Garcia, R</creatorcontrib><creatorcontrib>Oliveira, S</creatorcontrib><creatorcontrib>Brites, J</creatorcontrib><creatorcontrib>Ramos, F Oliveira</creatorcontrib><creatorcontrib>Canhão, H</creatorcontrib><creatorcontrib>Palma dos Reis, J</creatorcontrib><creatorcontrib>Pereira da Silva, J A</creatorcontrib><creatorcontrib>Lopes, T</creatorcontrib><title>Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objective
The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).
Methods
We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. We compared the OABq-SF scores for SB and HRQL between patients and controls using univariate and multivariate linear regression analysis.
Results
We recruited 95 rheumatic patients (68 SLE, 27 pSS) and 231 controls. Compared to controls SLE patients showed higher OABq-SF SB scores (22.6 ± 20.4 vs 14.7 ± 17.0, p = 0.004) and lower HRQL scores (89.8 ± 15.8 vs 93.8 ± 11.4, p = 0.044). On multivariate analysis SLE was significantly associated with a higher SB score (ß-coefficient 7.13, p = 0.008) and tended to be associated with worse HRQL values (ß-coefficient –3.53, p = 0.055). Patients with pSS had numerically higher mean SB scores (22.8 ± 22.5 vs 16.2 ± 18.0, respectively, p = 0.107) and lower HRQL scores (91.0 ± 10.7 vs 93.2 ± 11.6, respectively, p = 0.369), although these differences were not statistically significant. Diagnosis of pSS was not significantly associated with SB or HRQL scores on univariate or multivariate analysis.
Conclusions
Patients with SLE have significantly worse OAB-SB and poorer HRQL compared to controls. A similar trend was seen for pSS patients, especially for SB. These findings suggest that clinically subtle OAB symptoms may be present in rheumatic patients for whom, later on, bladder pain syndrome may occur.</description><subject>Bladder</subject><subject>Lupus</subject><subject>Multivariate analysis</subject><subject>Pain</subject><subject>Quality of life</subject><subject>Sjogren's syndrome</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctO3DAUhi1UBFPKnlVlqRs2Kb4k43hZoZYiIbGgXUe-nDAeOXGwHdC8RZ-mL8CL4dFMqYTEyjo-3_8dWwehM0q-UirEBZFLygjntG0pXZLmAC1oLURV7tkHtNi2q23_GH1MaU0I4VQuj9AxJzWVQvAF-nP7CFGZ7B4Ba6-shYjTZphyGLAOeVVKNVq8AuXzqorgVQaLH2blXd7g0GPvesBuxJPKDsac8JPLq6JIGQZnsJ-nOWGIm6IaVA6pVFvhFN2g4gbfrZ__3kcYS2K0MQzwCR32yic43Z8n6PeP778uf1Y3t1fXl99uKlMTkStupJBMcMLaBpQwmkBvFOuZokxLYRtGrQbOa63bggqpiTHEFl4ya2vFT9D5zjvF8DBDyt3gkgHv1QhhTh2jnAkmedMW9MsbdB3mOJbXFaqRTUN5IwpFdpSJIaUIfbf_Y0dJt91W93ZbJfJ5L571APY18G89Bah2QFL38H_qu8IXLBKf5A</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Pereira e Silva, R</creator><creator>Romão, V C</creator><creator>Neves, M</creator><creator>Garcia, R</creator><creator>Oliveira, S</creator><creator>Brites, J</creator><creator>Ramos, F Oliveira</creator><creator>Canhão, H</creator><creator>Palma dos Reis, J</creator><creator>Pereira da Silva, J A</creator><creator>Lopes, T</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4396-4921</orcidid></search><sort><creationdate>201901</creationdate><title>Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome</title><author>Pereira e Silva, R ; Romão, V C ; Neves, M ; Garcia, R ; Oliveira, S ; Brites, J ; Ramos, F Oliveira ; Canhão, H ; Palma dos Reis, J ; Pereira da Silva, J A ; Lopes, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-3c9792730285ea7cb0efca2f2a12b97d521dbe334bb8c9779b0cc0d30292dd4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bladder</topic><topic>Lupus</topic><topic>Multivariate analysis</topic><topic>Pain</topic><topic>Quality of life</topic><topic>Sjogren's syndrome</topic><topic>Statistical analysis</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira e Silva, R</creatorcontrib><creatorcontrib>Romão, V C</creatorcontrib><creatorcontrib>Neves, M</creatorcontrib><creatorcontrib>Garcia, R</creatorcontrib><creatorcontrib>Oliveira, S</creatorcontrib><creatorcontrib>Brites, J</creatorcontrib><creatorcontrib>Ramos, F Oliveira</creatorcontrib><creatorcontrib>Canhão, H</creatorcontrib><creatorcontrib>Palma dos Reis, J</creatorcontrib><creatorcontrib>Pereira da Silva, J A</creatorcontrib><creatorcontrib>Lopes, T</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira e Silva, R</au><au>Romão, V C</au><au>Neves, M</au><au>Garcia, R</au><au>Oliveira, S</au><au>Brites, J</au><au>Ramos, F Oliveira</au><au>Canhão, H</au><au>Palma dos Reis, J</au><au>Pereira da Silva, J A</au><au>Lopes, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2019-01</date><risdate>2019</risdate><volume>28</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective
The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).
Methods
We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. We compared the OABq-SF scores for SB and HRQL between patients and controls using univariate and multivariate linear regression analysis.
Results
We recruited 95 rheumatic patients (68 SLE, 27 pSS) and 231 controls. Compared to controls SLE patients showed higher OABq-SF SB scores (22.6 ± 20.4 vs 14.7 ± 17.0, p = 0.004) and lower HRQL scores (89.8 ± 15.8 vs 93.8 ± 11.4, p = 0.044). On multivariate analysis SLE was significantly associated with a higher SB score (ß-coefficient 7.13, p = 0.008) and tended to be associated with worse HRQL values (ß-coefficient –3.53, p = 0.055). Patients with pSS had numerically higher mean SB scores (22.8 ± 22.5 vs 16.2 ± 18.0, respectively, p = 0.107) and lower HRQL scores (91.0 ± 10.7 vs 93.2 ± 11.6, respectively, p = 0.369), although these differences were not statistically significant. Diagnosis of pSS was not significantly associated with SB or HRQL scores on univariate or multivariate analysis.
Conclusions
Patients with SLE have significantly worse OAB-SB and poorer HRQL compared to controls. A similar trend was seen for pSS patients, especially for SB. These findings suggest that clinically subtle OAB symptoms may be present in rheumatic patients for whom, later on, bladder pain syndrome may occur.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30419773</pmid><doi>10.1177/0961203318811605</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4396-4921</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals Online |
| subjects | Bladder Lupus Multivariate analysis Pain Quality of life Sjogren's syndrome Statistical analysis Systemic lupus erythematosus |
| title | Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome |
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