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Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?
Piezo channels play fundamental roles in many physiological processes. Their presence and functional role in the enteric nervous system is still not known. We hypothesize that they play a role in mechanotransduction in enteric neurons. Our aims are to quantify the presence of both Piezo1 and 2 in en...
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| Published in: | Cell and tissue research 2019-03, Vol.375 (3), p.605-618 |
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| creator | Mazzuoli-Weber, Gemma Kugler, Eva Maria Bühler, Carina Ines Kreutz, Florian Demir, Ihsan Ekin Ceyhan, Onur Güralp Zeller, Florian Schemann, Michael |
| description | Piezo channels play fundamental roles in many physiological processes. Their presence and functional role in the enteric nervous system is still not known. We hypothesize that they play a role in mechanotransduction in enteric neurons. Our aims are to quantify the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract using immunohistochemistry and analyze their function(s) using neuroimaging techniques and pharmacological investigations. In order to perform a systematic and comparative study, we performed our experiments in gastrointestinal tissue from guinea pigs, mice and humans. Piezo1 (20–70%) is expressed by both enteric neuronal cell bodies and fibers in the myenteric and submucosal plexi of all the species investigated. Generally, Piezo1 expressing somata are more numerous in the submucosal plexus (50–80%) than in the myenteric plexus (15–35%) apart from the stomach where Piezo1 is expressed in up to 60% of cell bodies. Myenteric Piezo1 neurons mainly (60–100%) but not exclusively, also express nitric oxide synthase, a minority express choline acetyltransferase. In the submucosal plexus, Piezo1 neurons co-express vasoactive intestinal peptide (40–90%). Conversely, expression of Piezo2 is extremely rare in the somata of enteric neurons and is present in few neurites. In functional experiments, 38–76% of the mechanosensitive neurons expressed Piezo1 channels. Statistical analysis showed a positive significant correlation between mechanosensitive and Piezo1 positive neurons. However, pharmacological experiments using an activator and an inhibitor of Piezo channels did not demonstrate changes in mechanotransduction. A major role of Piezo1 in the mechanosensitivity of enteric neurons can be excluded. |
| doi_str_mv | 10.1007/s00441-018-2926-7 |
| format | article |
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Is there a link with mechanosensitivity?</title><source>Springer Link</source><creator>Mazzuoli-Weber, Gemma ; Kugler, Eva Maria ; Bühler, Carina Ines ; Kreutz, Florian ; Demir, Ihsan Ekin ; Ceyhan, Onur Güralp ; Zeller, Florian ; Schemann, Michael</creator><creatorcontrib>Mazzuoli-Weber, Gemma ; Kugler, Eva Maria ; Bühler, Carina Ines ; Kreutz, Florian ; Demir, Ihsan Ekin ; Ceyhan, Onur Güralp ; Zeller, Florian ; Schemann, Michael</creatorcontrib><description>Piezo channels play fundamental roles in many physiological processes. Their presence and functional role in the enteric nervous system is still not known. We hypothesize that they play a role in mechanotransduction in enteric neurons. Our aims are to quantify the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract using immunohistochemistry and analyze their function(s) using neuroimaging techniques and pharmacological investigations. In order to perform a systematic and comparative study, we performed our experiments in gastrointestinal tissue from guinea pigs, mice and humans. Piezo1 (20–70%) is expressed by both enteric neuronal cell bodies and fibers in the myenteric and submucosal plexi of all the species investigated. Generally, Piezo1 expressing somata are more numerous in the submucosal plexus (50–80%) than in the myenteric plexus (15–35%) apart from the stomach where Piezo1 is expressed in up to 60% of cell bodies. Myenteric Piezo1 neurons mainly (60–100%) but not exclusively, also express nitric oxide synthase, a minority express choline acetyltransferase. In the submucosal plexus, Piezo1 neurons co-express vasoactive intestinal peptide (40–90%). Conversely, expression of Piezo2 is extremely rare in the somata of enteric neurons and is present in few neurites. In functional experiments, 38–76% of the mechanosensitive neurons expressed Piezo1 channels. Statistical analysis showed a positive significant correlation between mechanosensitive and Piezo1 positive neurons. However, pharmacological experiments using an activator and an inhibitor of Piezo channels did not demonstrate changes in mechanotransduction. A major role of Piezo1 in the mechanosensitivity of enteric neurons can be excluded.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-018-2926-7</identifier><identifier>PMID: 30324494</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetyltransferase ; Animal experimentation ; Axons ; Biomedical and Life Sciences ; Biomedicine ; Choline ; Choline O-acetyltransferase ; Comparative analysis ; Comparative literature ; Enteric nervous system ; Experiments ; Gastrointestinal system ; Gastrointestinal tract ; Human Genetics ; Immunohistochemistry ; Intestine ; Mechanotransduction ; Mediation ; Molecular Medicine ; Myenteric plexus ; Nervous system ; Neuroimaging ; Neurons ; Nitric oxide ; Nitric-oxide synthase ; Nitrogen oxides ; Peptides ; Physiological aspects ; Proteomics ; Regular Article ; Rodents ; Statistical analysis ; Stomach ; Submucosal plexus ; Vasoactive agents ; Vasoactive intestinal peptide ; Vasoactive intestinal peptides</subject><ispartof>Cell and tissue research, 2019-03, Vol.375 (3), p.605-618</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Cell and Tissue Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-b6118d4e554941f9d68b9caf32c9502ea07937109517f580c941891c3ffe13f63</citedby><cites>FETCH-LOGICAL-c470t-b6118d4e554941f9d68b9caf32c9502ea07937109517f580c941891c3ffe13f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30324494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazzuoli-Weber, Gemma</creatorcontrib><creatorcontrib>Kugler, Eva Maria</creatorcontrib><creatorcontrib>Bühler, Carina Ines</creatorcontrib><creatorcontrib>Kreutz, Florian</creatorcontrib><creatorcontrib>Demir, Ihsan Ekin</creatorcontrib><creatorcontrib>Ceyhan, Onur Güralp</creatorcontrib><creatorcontrib>Zeller, Florian</creatorcontrib><creatorcontrib>Schemann, Michael</creatorcontrib><title>Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Piezo channels play fundamental roles in many physiological processes. Their presence and functional role in the enteric nervous system is still not known. We hypothesize that they play a role in mechanotransduction in enteric neurons. Our aims are to quantify the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract using immunohistochemistry and analyze their function(s) using neuroimaging techniques and pharmacological investigations. In order to perform a systematic and comparative study, we performed our experiments in gastrointestinal tissue from guinea pigs, mice and humans. Piezo1 (20–70%) is expressed by both enteric neuronal cell bodies and fibers in the myenteric and submucosal plexi of all the species investigated. Generally, Piezo1 expressing somata are more numerous in the submucosal plexus (50–80%) than in the myenteric plexus (15–35%) apart from the stomach where Piezo1 is expressed in up to 60% of cell bodies. Myenteric Piezo1 neurons mainly (60–100%) but not exclusively, also express nitric oxide synthase, a minority express choline acetyltransferase. In the submucosal plexus, Piezo1 neurons co-express vasoactive intestinal peptide (40–90%). Conversely, expression of Piezo2 is extremely rare in the somata of enteric neurons and is present in few neurites. In functional experiments, 38–76% of the mechanosensitive neurons expressed Piezo1 channels. Statistical analysis showed a positive significant correlation between mechanosensitive and Piezo1 positive neurons. However, pharmacological experiments using an activator and an inhibitor of Piezo channels did not demonstrate changes in mechanotransduction. A major role of Piezo1 in the mechanosensitivity of enteric neurons can be excluded.</description><subject>Acetyltransferase</subject><subject>Animal experimentation</subject><subject>Axons</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Choline</subject><subject>Choline O-acetyltransferase</subject><subject>Comparative analysis</subject><subject>Comparative literature</subject><subject>Enteric nervous system</subject><subject>Experiments</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Human Genetics</subject><subject>Immunohistochemistry</subject><subject>Intestine</subject><subject>Mechanotransduction</subject><subject>Mediation</subject><subject>Molecular Medicine</subject><subject>Myenteric plexus</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>Neurons</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Nitrogen oxides</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Proteomics</subject><subject>Regular Article</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Stomach</subject><subject>Submucosal plexus</subject><subject>Vasoactive agents</subject><subject>Vasoactive intestinal peptide</subject><subject>Vasoactive intestinal peptides</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1klFrFTEQhYMo9lr9Ab5IQJC-7HWSbDa7vkgpVQsFfVDwLeRmZ3tTd5OaZCvXX2_WW60VJQ8hM985zJBDyFMGawagXiaAumYVsLbiHW8qdY-sWC14Ba1q75MVCOCVaprPB-RRSpcArG6a7iE5ECB4XXf1ioQPDr8HehVDRufTK-q8dT16i9T4nprN7HuzvJyneYsUfcboLPUYr8OcaNqljNOanqWlHYuKjs5_od9c3tIJ7db4kNAnl921y7vXj8mDwYwJn9zch-TTm9OPJ--q8_dvz06OzytbK8jVpmGs7WuUskzJhq5v2k1nzSC47SRwNKA6oRh0kqlBtmAL1XbMimFAJoZGHJKjvW_Z7OuMKevJJYvjaDyWuTVnHJRsgEFBn_-FXoY5-jLdTwqY4FLeUhdmRO38EHI0djHVx1IpaKVgbaHW_6DK6XFyNngcXKnfEbz4Q7BFM-ZtCuOcXfDpLsj2oI0hpYiDvopuMnGnGeglDXqfBl3SoJc0aFU0z242mzcT9r8Vv76_AHwPpNLyFxhvV_-_6w_1gbxm</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Mazzuoli-Weber, Gemma</creator><creator>Kugler, Eva Maria</creator><creator>Bühler, Carina Ines</creator><creator>Kreutz, Florian</creator><creator>Demir, Ihsan Ekin</creator><creator>Ceyhan, Onur Güralp</creator><creator>Zeller, Florian</creator><creator>Schemann, Michael</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190301</creationdate><title>Piezo proteins: incidence and abundance in the enteric nervous system. 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Is there a link with mechanosensitivity?</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>375</volume><issue>3</issue><spage>605</spage><epage>618</epage><pages>605-618</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Piezo channels play fundamental roles in many physiological processes. Their presence and functional role in the enteric nervous system is still not known. We hypothesize that they play a role in mechanotransduction in enteric neurons. Our aims are to quantify the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract using immunohistochemistry and analyze their function(s) using neuroimaging techniques and pharmacological investigations. In order to perform a systematic and comparative study, we performed our experiments in gastrointestinal tissue from guinea pigs, mice and humans. Piezo1 (20–70%) is expressed by both enteric neuronal cell bodies and fibers in the myenteric and submucosal plexi of all the species investigated. Generally, Piezo1 expressing somata are more numerous in the submucosal plexus (50–80%) than in the myenteric plexus (15–35%) apart from the stomach where Piezo1 is expressed in up to 60% of cell bodies. Myenteric Piezo1 neurons mainly (60–100%) but not exclusively, also express nitric oxide synthase, a minority express choline acetyltransferase. In the submucosal plexus, Piezo1 neurons co-express vasoactive intestinal peptide (40–90%). Conversely, expression of Piezo2 is extremely rare in the somata of enteric neurons and is present in few neurites. In functional experiments, 38–76% of the mechanosensitive neurons expressed Piezo1 channels. Statistical analysis showed a positive significant correlation between mechanosensitive and Piezo1 positive neurons. However, pharmacological experiments using an activator and an inhibitor of Piezo channels did not demonstrate changes in mechanotransduction. A major role of Piezo1 in the mechanosensitivity of enteric neurons can be excluded.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30324494</pmid><doi>10.1007/s00441-018-2926-7</doi><tpages>14</tpages></addata></record> |
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| subjects | Acetyltransferase Animal experimentation Axons Biomedical and Life Sciences Biomedicine Choline Choline O-acetyltransferase Comparative analysis Comparative literature Enteric nervous system Experiments Gastrointestinal system Gastrointestinal tract Human Genetics Immunohistochemistry Intestine Mechanotransduction Mediation Molecular Medicine Myenteric plexus Nervous system Neuroimaging Neurons Nitric oxide Nitric-oxide synthase Nitrogen oxides Peptides Physiological aspects Proteomics Regular Article Rodents Statistical analysis Stomach Submucosal plexus Vasoactive agents Vasoactive intestinal peptide Vasoactive intestinal peptides |
| title | Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity? |
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