Refining the Effects Observed in a Developmental Neurobehavioral Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats. I. Thyroid and Reproductive Effects

A recent study further investigated the potential effects of maternal thyroid function and morphology on fetal development upon maternal exposure to ammonium perchlorate during gestation and lactation. Female Sprague-Dawley rats (25/group) were given continual access to 0 (carrier), 0.01, 0.1, 1.0,...

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Bibliographic Details
Published in:International journal of toxicology 2005-11, Vol.24 (6), p.403-418
Main Authors: York, Raymond G., Lewis, Elise, Brown, W. Ray, Girard, Michael F., Mattie, David R., Funk, Kathleen A., Strawson, Joan S.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Animals, Newborn
Behavior, Animal - drug effects
Brain - drug effects
Brain - growth & development
Dose-Response Relationship, Drug
Female
Lactation
Male
Maternal Exposure
No-Observed-Adverse-Effect Level
Organ Size - drug effects
Perchlorates - administration & dosage
Perchlorates - toxicity
Pregnancy
Prenatal Exposure Delayed Effects
Quaternary Ammonium Compounds - administration & dosage
Quaternary Ammonium Compounds - toxicity
Rats
Rats, Sprague-Dawley
Reproduction - drug effects
Thyroid Gland - drug effects
Thyroid Gland - growth & development
Thyroid Gland - pathology
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
Water Pollutants, Chemical - administration & dosage
Water Pollutants, Chemical - toxicity
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Summary:A recent study further investigated the potential effects of maternal thyroid function and morphology on fetal development upon maternal exposure to ammonium perchlorate during gestation and lactation. Female Sprague-Dawley rats (25/group) were given continual access to 0 (carrier), 0.01, 0.1, 1.0, and 30.0 mg/kg-day perchlorate in drinking water beginning 2 weeks prior to cohabitation through lactation day 10. Maternal, fetal, and pup serum thyroid hormone (thyroid-stimulating hormone [TSH], triiodo thyronine [T3], thyroxine [T4]) levels and thyroid histopathology were evaluated on gestation day 21, and lactation days 5, 10, and 22. No effects of exposure were observed on cesarean-sectioning, litter parameters, or fetal alterations. Reproductive parameters, including gestation length, number of implants, litter size, pup viability, and lactation indices, were comparable among all groups. Thyroid weights of dams sacrificed on gestation day 21, and lactation days 10 and 22 were significantly increased at 30.0 mg/kg-day. Increased thyroid weights were observed in male and female pups as early as postpartum days 5 and 10, respectively. Changes in maternal and neonatal thyroid histopathology were detectable at 1.0 mg/kg-day exposure. The maternal no-observable-effect level (NOEL) was 0.1 mg/kg-day (follicular cell hyperplasia was present at 1.0 and 30.0 mg/kg-day). The developmental NOEL was less than 0.01 mg/kg-day; thyroid weights of postpartum day 10 pups were increased at all exposures. Colloid depletion at 1.0 and 30.0 mg/kg-day exposures and changes of hormone levels at all exposures were considered an adaptive effect and appeared reversible in the rodent.
ISSN:1091-5818
1092-874X
DOI:10.1080/10915810500366765