Loading…
Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica
•Close to half of the patients with previous pregnancies reported at least one gestational loss. This percentage is higher than expected for their age group in our country.•Most of these pregnancy losses occurred years before the diagnosis of NMO.•AQP4-IgG can be detected in serum more than 10 years...
Saved in:
| Published in: | Multiple sclerosis and related disorders 2018-10, Vol.25, p.268-270 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43 |
| container_end_page | 270 |
| container_issue | |
| container_start_page | 268 |
| container_title | Multiple sclerosis and related disorders |
| container_volume | 25 |
| creator | Delgado-García, Guillermo Chávez, Zoé Rivas-Alonso, Verónica Corona, Teresa Flores-Rivera, José |
| description | •Close to half of the patients with previous pregnancies reported at least one gestational loss. This percentage is higher than expected for their age group in our country.•Most of these pregnancy losses occurred years before the diagnosis of NMO.•AQP4-IgG can be detected in serum more than 10 years before the NMO onset and can cause miscarriage by binding to placental AQP4, activating complement, and causing inflammatory infiltration.
Background: Previous studies have investigated the influence of neuromyelitis optica (NMO) on pregnancy in other ethnic groups. However, there are potential variations among ethnic groups. The obstetric outcome of Mexican patients with NMO and AQP4-IgG positivity (AQP4-IgG[+]) is currently unknown. Objective: To describe the obstetric history of Mexican patients with NMO and AQP4-IgG(+). Methods: Patients with NMO and AQP4-IgG(+) were identified from the database of the Demyelinating Diseases Clinic. These patients were interviewed by telephone. Results: Out of a total of 40 eligible patients, 29 were contacted and completed the survey. Of these, 19 patients reported at least one previous pregnancy. In total, 50 pregnancies were reported: 44 of them occurred ≥ 3 years before the first clinical manifestation, 1 occurred ≥ 1 years before, and 1 occurred after the first manifestation. Of all pregnancies, 12 were pregnancy losses: 5 were classified as miscarriages and 3 as stillbirths. Of all pregnancy losses, 10 occurred ≥ 3 years before the diagnosis, 1 occurred after the first manifestation. All pregnancy losses occurred in 8 patients. Conclusions: Close to half of the patients with previous pregnancies reported at least one pregnancy loss, most of these occurred ≥ 3 years before the diagnosis. This percentage is higher than expected for their age group in our country. |
| doi_str_mv | 10.1016/j.msard.2018.08.015 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2095542385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2211034818302931</els_id><sourcerecordid>2095542385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43</originalsourceid><addsrcrecordid>eNp9kE1rGzEQhkVpaEySX1AIOvayzmj1Ye8hB2OaJpCSBNqz0EqzjYx3tZW0Sf3vK8epjx0GZgbeeYd5CPnMYM6AqavNvE8munkNbDmHkkx-ILO6ZqwCLtXHYy-Wp-QipQ2UUJIJxT6RUw5MNBz4jPx6aFPGHL2lYco29JioH6ih3_GPt2agNjyHmGno6GiyxyEn-urzM109PYrKDNm3we2qhDGMIfnsX5AOOMXQ73BbxkTDmIvROTnpzDbhxXs9Iz9vvv5Y31b3D9_u1qv7ynLZ5Ao7CcCwUwuQwpnGNq21TnWuAViI1iwW0jglXdcw5DWDpTINF62qLatN1wp-Rr4cfMcYfk-Ysu59srjdmgHDlHQNjZSi5ktZpPwgtTGkFLHTY_S9iTvNQO8h641-g6z3kDWUZPuty_cDU9ujO-78Q1oE1wcBljdfPEadbOFm0fmINmsX_H8P_AXYn5AA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2095542385</pqid></control><display><type>article</type><title>Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica</title><source>ScienceDirect Journals</source><creator>Delgado-García, Guillermo ; Chávez, Zoé ; Rivas-Alonso, Verónica ; Corona, Teresa ; Flores-Rivera, José</creator><creatorcontrib>Delgado-García, Guillermo ; Chávez, Zoé ; Rivas-Alonso, Verónica ; Corona, Teresa ; Flores-Rivera, José</creatorcontrib><description>•Close to half of the patients with previous pregnancies reported at least one gestational loss. This percentage is higher than expected for their age group in our country.•Most of these pregnancy losses occurred years before the diagnosis of NMO.•AQP4-IgG can be detected in serum more than 10 years before the NMO onset and can cause miscarriage by binding to placental AQP4, activating complement, and causing inflammatory infiltration.
Background: Previous studies have investigated the influence of neuromyelitis optica (NMO) on pregnancy in other ethnic groups. However, there are potential variations among ethnic groups. The obstetric outcome of Mexican patients with NMO and AQP4-IgG positivity (AQP4-IgG[+]) is currently unknown. Objective: To describe the obstetric history of Mexican patients with NMO and AQP4-IgG(+). Methods: Patients with NMO and AQP4-IgG(+) were identified from the database of the Demyelinating Diseases Clinic. These patients were interviewed by telephone. Results: Out of a total of 40 eligible patients, 29 were contacted and completed the survey. Of these, 19 patients reported at least one previous pregnancy. In total, 50 pregnancies were reported: 44 of them occurred ≥ 3 years before the first clinical manifestation, 1 occurred ≥ 1 years before, and 1 occurred after the first manifestation. Of all pregnancies, 12 were pregnancy losses: 5 were classified as miscarriages and 3 as stillbirths. Of all pregnancy losses, 10 occurred ≥ 3 years before the diagnosis, 1 occurred after the first manifestation. All pregnancy losses occurred in 8 patients. Conclusions: Close to half of the patients with previous pregnancies reported at least one pregnancy loss, most of these occurred ≥ 3 years before the diagnosis. This percentage is higher than expected for their age group in our country.</description><identifier>ISSN: 2211-0348</identifier><identifier>EISSN: 2211-0356</identifier><identifier>DOI: 10.1016/j.msard.2018.08.015</identifier><identifier>PMID: 30149303</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abortion ; Adult ; Aquaporin 4 ; Aquaporin 4 - immunology ; Autoantibodies - blood ; Female ; Hispanics ; Humans ; Immunologic Factors - adverse effects ; Mexico - epidemiology ; Middle Aged ; Neuromyelitis optica ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - complications ; Neuromyelitis Optica - drug therapy ; Obstetric Labor Complications - epidemiology ; Obstetric Labor Complications - etiology ; Pregnancy ; Pregnancy complications ; Pregnancy outcome ; Spontaneous abortion</subject><ispartof>Multiple sclerosis and related disorders, 2018-10, Vol.25, p.268-270</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43</citedby><cites>FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43</cites><orcidid>0000-0002-3123-5879</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30149303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delgado-García, Guillermo</creatorcontrib><creatorcontrib>Chávez, Zoé</creatorcontrib><creatorcontrib>Rivas-Alonso, Verónica</creatorcontrib><creatorcontrib>Corona, Teresa</creatorcontrib><creatorcontrib>Flores-Rivera, José</creatorcontrib><title>Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica</title><title>Multiple sclerosis and related disorders</title><addtitle>Mult Scler Relat Disord</addtitle><description>•Close to half of the patients with previous pregnancies reported at least one gestational loss. This percentage is higher than expected for their age group in our country.•Most of these pregnancy losses occurred years before the diagnosis of NMO.•AQP4-IgG can be detected in serum more than 10 years before the NMO onset and can cause miscarriage by binding to placental AQP4, activating complement, and causing inflammatory infiltration.
Background: Previous studies have investigated the influence of neuromyelitis optica (NMO) on pregnancy in other ethnic groups. However, there are potential variations among ethnic groups. The obstetric outcome of Mexican patients with NMO and AQP4-IgG positivity (AQP4-IgG[+]) is currently unknown. Objective: To describe the obstetric history of Mexican patients with NMO and AQP4-IgG(+). Methods: Patients with NMO and AQP4-IgG(+) were identified from the database of the Demyelinating Diseases Clinic. These patients were interviewed by telephone. Results: Out of a total of 40 eligible patients, 29 were contacted and completed the survey. Of these, 19 patients reported at least one previous pregnancy. In total, 50 pregnancies were reported: 44 of them occurred ≥ 3 years before the first clinical manifestation, 1 occurred ≥ 1 years before, and 1 occurred after the first manifestation. Of all pregnancies, 12 were pregnancy losses: 5 were classified as miscarriages and 3 as stillbirths. Of all pregnancy losses, 10 occurred ≥ 3 years before the diagnosis, 1 occurred after the first manifestation. All pregnancy losses occurred in 8 patients. Conclusions: Close to half of the patients with previous pregnancies reported at least one pregnancy loss, most of these occurred ≥ 3 years before the diagnosis. This percentage is higher than expected for their age group in our country.</description><subject>Abortion</subject><subject>Adult</subject><subject>Aquaporin 4</subject><subject>Aquaporin 4 - immunology</subject><subject>Autoantibodies - blood</subject><subject>Female</subject><subject>Hispanics</subject><subject>Humans</subject><subject>Immunologic Factors - adverse effects</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Neuromyelitis optica</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - complications</subject><subject>Neuromyelitis Optica - drug therapy</subject><subject>Obstetric Labor Complications - epidemiology</subject><subject>Obstetric Labor Complications - etiology</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy outcome</subject><subject>Spontaneous abortion</subject><issn>2211-0348</issn><issn>2211-0356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rGzEQhkVpaEySX1AIOvayzmj1Ye8hB2OaJpCSBNqz0EqzjYx3tZW0Sf3vK8epjx0GZgbeeYd5CPnMYM6AqavNvE8munkNbDmHkkx-ILO6ZqwCLtXHYy-Wp-QipQ2UUJIJxT6RUw5MNBz4jPx6aFPGHL2lYco29JioH6ih3_GPt2agNjyHmGno6GiyxyEn-urzM109PYrKDNm3we2qhDGMIfnsX5AOOMXQ73BbxkTDmIvROTnpzDbhxXs9Iz9vvv5Y31b3D9_u1qv7ynLZ5Ao7CcCwUwuQwpnGNq21TnWuAViI1iwW0jglXdcw5DWDpTINF62qLatN1wp-Rr4cfMcYfk-Ysu59srjdmgHDlHQNjZSi5ktZpPwgtTGkFLHTY_S9iTvNQO8h641-g6z3kDWUZPuty_cDU9ujO-78Q1oE1wcBljdfPEadbOFm0fmINmsX_H8P_AXYn5AA</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Delgado-García, Guillermo</creator><creator>Chávez, Zoé</creator><creator>Rivas-Alonso, Verónica</creator><creator>Corona, Teresa</creator><creator>Flores-Rivera, José</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3123-5879</orcidid></search><sort><creationdate>201810</creationdate><title>Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica</title><author>Delgado-García, Guillermo ; Chávez, Zoé ; Rivas-Alonso, Verónica ; Corona, Teresa ; Flores-Rivera, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abortion</topic><topic>Adult</topic><topic>Aquaporin 4</topic><topic>Aquaporin 4 - immunology</topic><topic>Autoantibodies - blood</topic><topic>Female</topic><topic>Hispanics</topic><topic>Humans</topic><topic>Immunologic Factors - adverse effects</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Neuromyelitis optica</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - complications</topic><topic>Neuromyelitis Optica - drug therapy</topic><topic>Obstetric Labor Complications - epidemiology</topic><topic>Obstetric Labor Complications - etiology</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy outcome</topic><topic>Spontaneous abortion</topic><toplevel>online_resources</toplevel><creatorcontrib>Delgado-García, Guillermo</creatorcontrib><creatorcontrib>Chávez, Zoé</creatorcontrib><creatorcontrib>Rivas-Alonso, Verónica</creatorcontrib><creatorcontrib>Corona, Teresa</creatorcontrib><creatorcontrib>Flores-Rivera, José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis and related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delgado-García, Guillermo</au><au>Chávez, Zoé</au><au>Rivas-Alonso, Verónica</au><au>Corona, Teresa</au><au>Flores-Rivera, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica</atitle><jtitle>Multiple sclerosis and related disorders</jtitle><addtitle>Mult Scler Relat Disord</addtitle><date>2018-10</date><risdate>2018</risdate><volume>25</volume><spage>268</spage><epage>270</epage><pages>268-270</pages><issn>2211-0348</issn><eissn>2211-0356</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>•Close to half of the patients with previous pregnancies reported at least one gestational loss. This percentage is higher than expected for their age group in our country.•Most of these pregnancy losses occurred years before the diagnosis of NMO.•AQP4-IgG can be detected in serum more than 10 years before the NMO onset and can cause miscarriage by binding to placental AQP4, activating complement, and causing inflammatory infiltration.
Background: Previous studies have investigated the influence of neuromyelitis optica (NMO) on pregnancy in other ethnic groups. However, there are potential variations among ethnic groups. The obstetric outcome of Mexican patients with NMO and AQP4-IgG positivity (AQP4-IgG[+]) is currently unknown. Objective: To describe the obstetric history of Mexican patients with NMO and AQP4-IgG(+). Methods: Patients with NMO and AQP4-IgG(+) were identified from the database of the Demyelinating Diseases Clinic. These patients were interviewed by telephone. Results: Out of a total of 40 eligible patients, 29 were contacted and completed the survey. Of these, 19 patients reported at least one previous pregnancy. In total, 50 pregnancies were reported: 44 of them occurred ≥ 3 years before the first clinical manifestation, 1 occurred ≥ 1 years before, and 1 occurred after the first manifestation. Of all pregnancies, 12 were pregnancy losses: 5 were classified as miscarriages and 3 as stillbirths. Of all pregnancy losses, 10 occurred ≥ 3 years before the diagnosis, 1 occurred after the first manifestation. All pregnancy losses occurred in 8 patients. Conclusions: Close to half of the patients with previous pregnancies reported at least one pregnancy loss, most of these occurred ≥ 3 years before the diagnosis. This percentage is higher than expected for their age group in our country.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30149303</pmid><doi>10.1016/j.msard.2018.08.015</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-3123-5879</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2211-0348 |
| ispartof | Multiple sclerosis and related disorders, 2018-10, Vol.25, p.268-270 |
| issn | 2211-0348 2211-0356 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2095542385 |
| source | ScienceDirect Journals |
| subjects | Abortion Adult Aquaporin 4 Aquaporin 4 - immunology Autoantibodies - blood Female Hispanics Humans Immunologic Factors - adverse effects Mexico - epidemiology Middle Aged Neuromyelitis optica Neuromyelitis Optica - blood Neuromyelitis Optica - complications Neuromyelitis Optica - drug therapy Obstetric Labor Complications - epidemiology Obstetric Labor Complications - etiology Pregnancy Pregnancy complications Pregnancy outcome Spontaneous abortion |
| title | Obstetric outcomes in a Mexican cohort of patients with AQP4-antibody-seropositive neuromyelitis optica |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T12%3A47%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obstetric%20outcomes%20in%20a%20Mexican%20cohort%20of%20patients%20with%20AQP4-antibody-seropositive%20neuromyelitis%20optica&rft.jtitle=Multiple%20sclerosis%20and%20related%20disorders&rft.au=Delgado-Garc%C3%ADa,%20Guillermo&rft.date=2018-10&rft.volume=25&rft.spage=268&rft.epage=270&rft.pages=268-270&rft.issn=2211-0348&rft.eissn=2211-0356&rft_id=info:doi/10.1016/j.msard.2018.08.015&rft_dat=%3Cproquest_cross%3E2095542385%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c359t-ef5001ef67054da9c9bccd6fd90074ba775ad65df91e321086a934b62c12afb43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2095542385&rft_id=info:pmid/30149303&rfr_iscdi=true |