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Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat
The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expr...
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| Published in: | Behavioural brain research 2009-03, Vol.198 (2), p.466-471 |
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| container_end_page | 471 |
| container_issue | 2 |
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| container_title | Behavioural brain research |
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| creator | Moaddab, Mahsa Haghparast, Abbas Hassanpour-Ezatti, Majid |
| description | The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in rats. One hundred and eighty-one adult male albino Wistar rats were used in these experiments. Reversible inactivation of VTA was done through the unilateral and bilateral intra-VTA microinjection of 2% lidocaine during the acquisition and expression of morphine (5
mg/kg; s.c.)-induced CPP. Animal displacement, conditioning score and locomotor activity were recorded by Ethovision software. The results showed that bilateral but not unilateral intra-VTA administration of lidocaine significantly decreases the acquisition (
P
<
0.01) and expression (
P
<
0.05) of morphine-induced CPP compared to their respective saline-microinjected groups. Moreover, intra-VTA administration of lidocaine had no effect on locomotor activity in these experiments. Our results further support the idea that VTA may play an important role in the acquisition of morphine-induced CPP. In addition, there is no functional lateralization in the VTA for acquisition and/or expression of morphine-induced CPP in the rat. |
| doi_str_mv | 10.1016/j.bbr.2008.11.030 |
| format | article |
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mg/kg; s.c.)-induced CPP. Animal displacement, conditioning score and locomotor activity were recorded by Ethovision software. The results showed that bilateral but not unilateral intra-VTA administration of lidocaine significantly decreases the acquisition (
P
<
0.01) and expression (
P
<
0.05) of morphine-induced CPP compared to their respective saline-microinjected groups. Moreover, intra-VTA administration of lidocaine had no effect on locomotor activity in these experiments. Our results further support the idea that VTA may play an important role in the acquisition of morphine-induced CPP. In addition, there is no functional lateralization in the VTA for acquisition and/or expression of morphine-induced CPP in the rat.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2008.11.030</identifier><identifier>PMID: 19073220</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Analgesics, Opioid - pharmacology ; Anesthetics, Local - administration & dosage ; Anesthetics, Local - toxicity ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Conditioned place preference ; Conditioning, Operant - drug effects ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Injections, Subcutaneous ; Lidocaine ; Lidocaine - administration & dosage ; Lidocaine - toxicity ; Locomotor activity ; Male ; Microinjections ; Morphine ; Morphine - administration & dosage ; Morphine - pharmacology ; Motor Activity - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Reinforcement (Psychology) ; Reversible inactivation ; Spatial Behavior - drug effects ; Ventral tegmental area ; Ventral Tegmental Area - drug effects ; Ventral Tegmental Area - physiology</subject><ispartof>Behavioural brain research, 2009-03, Vol.198 (2), p.466-471</ispartof><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-14ee70fe5ac961532dba2c03b7c4f680995bfa3a6b7bdd08b23fdbb7b47fd3423</citedby><cites>FETCH-LOGICAL-c412t-14ee70fe5ac961532dba2c03b7c4f680995bfa3a6b7bdd08b23fdbb7b47fd3423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21273729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19073220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moaddab, Mahsa</creatorcontrib><creatorcontrib>Haghparast, Abbas</creatorcontrib><creatorcontrib>Hassanpour-Ezatti, Majid</creatorcontrib><title>Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in rats. One hundred and eighty-one adult male albino Wistar rats were used in these experiments. Reversible inactivation of VTA was done through the unilateral and bilateral intra-VTA microinjection of 2% lidocaine during the acquisition and expression of morphine (5
mg/kg; s.c.)-induced CPP. Animal displacement, conditioning score and locomotor activity were recorded by Ethovision software. The results showed that bilateral but not unilateral intra-VTA administration of lidocaine significantly decreases the acquisition (
P
<
0.01) and expression (
P
<
0.05) of morphine-induced CPP compared to their respective saline-microinjected groups. Moreover, intra-VTA administration of lidocaine had no effect on locomotor activity in these experiments. Our results further support the idea that VTA may play an important role in the acquisition of morphine-induced CPP. In addition, there is no functional lateralization in the VTA for acquisition and/or expression of morphine-induced CPP in the rat.</description><subject>Analgesics, Opioid - pharmacology</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - toxicity</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioned place preference</subject><subject>Conditioning, Operant - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Subcutaneous</subject><subject>Lidocaine</subject><subject>Lidocaine - administration & dosage</subject><subject>Lidocaine - toxicity</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Microinjections</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reinforcement (Psychology)</subject><subject>Reversible inactivation</subject><subject>Spatial Behavior - drug effects</subject><subject>Ventral tegmental area</subject><subject>Ventral Tegmental Area - drug effects</subject><subject>Ventral Tegmental Area - physiology</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kcuO1DAQRS0EYpqBD2CDsoFdgh9JnIgVGg0PaSQ2sLbKdplxK3EydtJifoZvxemOYMfK16pzq0p1CXnNaMUoa98fK61jxSntKsYqKugTcmCd5KVs6v4pOWSmLWvBuyvyIqUjpbSmDXtOrlhPpeCcHsjvW-fQLKmYXBHxhDF5PWDhA5jFn2DxU9hKyz0WJwxLhKFY8OeYZVYQEYoMbFUwD6tP_myAYAv8NUdMafePU5zvfcDSB7satIWZgj3DWc8DGCwy7jBiMNv0c8sIy0vyzMGQ8NX-XpMfn26_33wp7759_nrz8a40NeNLyWpESR02YPqWNYJbDdxQoaWpXdvRvm-0AwGtltpa2mkunNX5U0tnRc3FNXl36TvH6WHFtKjRJ4PDAAGnNSlORb4jZxlkF9DEKaW8spqjHyE-KkbVFoo6qhyK2kJRjKkcSva82ZuvekT7z7GnkIG3OwDJwOAiBOPTX44zLoXkfeY-XDjMpzh5jCoZv13M-phDVHby_1njD8oCrhY</recordid><startdate>20090317</startdate><enddate>20090317</enddate><creator>Moaddab, Mahsa</creator><creator>Haghparast, Abbas</creator><creator>Hassanpour-Ezatti, Majid</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20090317</creationdate><title>Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat</title><author>Moaddab, Mahsa ; Haghparast, Abbas ; Hassanpour-Ezatti, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-14ee70fe5ac961532dba2c03b7c4f680995bfa3a6b7bdd08b23fdbb7b47fd3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analgesics, Opioid - pharmacology</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - toxicity</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Conditioned place preference</topic><topic>Conditioning, Operant - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Subcutaneous</topic><topic>Lidocaine</topic><topic>Lidocaine - administration & dosage</topic><topic>Lidocaine - toxicity</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Microinjections</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - pharmacology</topic><topic>Motor Activity - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reinforcement (Psychology)</topic><topic>Reversible inactivation</topic><topic>Spatial Behavior - drug effects</topic><topic>Ventral tegmental area</topic><topic>Ventral Tegmental Area - drug effects</topic><topic>Ventral Tegmental Area - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moaddab, Mahsa</creatorcontrib><creatorcontrib>Haghparast, Abbas</creatorcontrib><creatorcontrib>Hassanpour-Ezatti, Majid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moaddab, Mahsa</au><au>Haghparast, Abbas</au><au>Hassanpour-Ezatti, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2009-03-17</date><risdate>2009</risdate><volume>198</volume><issue>2</issue><spage>466</spage><epage>471</epage><pages>466-471</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in rats. One hundred and eighty-one adult male albino Wistar rats were used in these experiments. Reversible inactivation of VTA was done through the unilateral and bilateral intra-VTA microinjection of 2% lidocaine during the acquisition and expression of morphine (5
mg/kg; s.c.)-induced CPP. Animal displacement, conditioning score and locomotor activity were recorded by Ethovision software. The results showed that bilateral but not unilateral intra-VTA administration of lidocaine significantly decreases the acquisition (
P
<
0.01) and expression (
P
<
0.05) of morphine-induced CPP compared to their respective saline-microinjected groups. Moreover, intra-VTA administration of lidocaine had no effect on locomotor activity in these experiments. Our results further support the idea that VTA may play an important role in the acquisition of morphine-induced CPP. In addition, there is no functional lateralization in the VTA for acquisition and/or expression of morphine-induced CPP in the rat.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>19073220</pmid><doi>10.1016/j.bbr.2008.11.030</doi><tpages>6</tpages></addata></record> |
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| ispartof | Behavioural brain research, 2009-03, Vol.198 (2), p.466-471 |
| issn | 0166-4328 1872-7549 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Analgesics, Opioid - pharmacology Anesthetics, Local - administration & dosage Anesthetics, Local - toxicity Animals Behavioral psychophysiology Biological and medical sciences Conditioned place preference Conditioning, Operant - drug effects Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Injections, Subcutaneous Lidocaine Lidocaine - administration & dosage Lidocaine - toxicity Locomotor activity Male Microinjections Morphine Morphine - administration & dosage Morphine - pharmacology Motor Activity - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reinforcement (Psychology) Reversible inactivation Spatial Behavior - drug effects Ventral tegmental area Ventral Tegmental Area - drug effects Ventral Tegmental Area - physiology |
| title | Effects of reversible inactivation of the ventral tegmental area on the acquisition and expression of morphine-induced conditioned place preference in the rat |
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