Recent Emergence of Insensitive Acetylcholinesterase in Chinese Populations of the Mosquito Culex pipiens (Diptera: Culicidae)

Organophosphate/carbamate target resistance has emerged in Culex pipiens L. (Diptera: Culicidae), the vector of Wuchereria bancrofti and West Nile virus (family Flaviviridae, genus Flavivirus) in China. The insensitive acetylcholinesterase was detected in only one of 20 samples collected on a north-...

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Bibliographic Details
Published in:Journal of medical entomology 2006-09, Vol.43 (5), p.878-883
Main Authors: Cui, Feng, Raymond, Michel, Berthomieu, Arnaud, Alout, Haoues, Weill, Mylène, Qiao, Chuan-ling
Format: Article
Language:English
Subjects:
Culex pipiens
Culicidae
Diptera
Flaviviridae
Flavivirus
Freshwater
West Nile virus
Wuchereria bancrofti
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Summary:Organophosphate/carbamate target resistance has emerged in Culex pipiens L. (Diptera: Culicidae), the vector of Wuchereria bancrofti and West Nile virus (family Flaviviridae, genus Flavivirus) in China. The insensitive acetylcholinesterase was detected in only one of 20 samples collected on a north-to-south transect. According to previous findings, a unique mutation, G119S in the ace-1 gene, explained this high insensitivity. Phylogenetic analysis indicates that the mutation G119S recently detected in China results from an independent mutation event. The G119S mutation thus occurred at least three times independently within the Cx. pipiens complex, once in the temperate (Cx. p. pipiens) and twice in the tropical form (Cx. p. quinquefasciatus). Bioassays performed with a purified G119S strain indicated that this substitution was associated with high levels of resistance to chlorpyrifos, fenitrothion, malathion, and parathion, but low levels of resistance to dichlorvos, trichlorfon, and fenthion. Hence, it is possible that in China, dichlorvos, trichlorfon, and fenthion will still achieve effective control even in the presence of the G119S mutation.
ISSN:0022-2585
0022-2585
DOI:10.1603/0022-2585(2006)43[878:REOIAI]2.0.CO;2