Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae

Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened...

Full description

Saved in:
Bibliographic Details
Published in:Applied microbiology and biotechnology 2006-07, Vol.71 (3), p.339-349
Main Authors: GORSICH, S. W, DIEN, B. S, NICHOLS, N. N, SLININGER, P. J, LIU, Z. L, SKORY, C. D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Carbohydrate Epimerases - genetics
Carbohydrate Epimerases - metabolism
Cellulose - metabolism
Fundamental and applied biological sciences. Psychology
Furaldehyde - analogs & derivatives
Furaldehyde - pharmacology
Gene Expression Regulation, Fungal
Genetics
Glucosephosphate Dehydrogenase - genetics
Glucosephosphate Dehydrogenase - metabolism
Heat-Shock Response
Lignin - metabolism
Mutation
Pentose Phosphate Pathway
Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Transketolase - genetics
Transketolase - metabolism
Yeast
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993
cites cdi_FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993
container_end_page 349
container_issue 3
container_start_page 339
container_title Applied microbiology and biotechnology
container_volume 71
creator GORSICH, S. W
DIEN, B. S
NICHOLS, N. N
SLININGER, P. J
LIU, Z. L
SKORY, C. D
description Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these genes would provide a growth benefit in the presence of furfural. Sixty two mutants were identified whose corresponding genes function in a wide spectrum of physiological pathways, suggesting that furfural tolerance is a complex process. We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes. At various concentrations of furfural and HMF, a clear association with higher sensitivity to these inhibitors was demonstrated in these mutants. PPP mutants were inefficient at reducing furfural to the less toxic furfuryl alcohol, which we propose is a result of an overall decreased abundance of reducing equivalents or to NADPH's role in stress tolerance. Overexpression of ZWF1 in S. cerevisiae allowed growth at furfural concentrations that are normally toxic. These results demonstrate a strong relationship between PPP genes and furfural tolerance and provide additional putative target genes involved in furfural tolerance.
doi_str_mv 10.1007/s00253-005-0142-3
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19842472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2087339501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993</originalsourceid><addsrcrecordid>eNpdkd2KFDEQRhtR3HH1AbyRIOiVranO_6Wsu6s4qOiI4E1Ip9NOlp5Om-p2mZfwmc0wAwtCUQXF-YqCU1VPgb4GStUbpLQRrKZU1BR4U7N71Qo4a2oqgd-vVhSUqJUw-qx6hHhDKTRayofVGcimKUlYVX83aQjZjT6QOZF-yaXcUMexW3zoCM45IJKIxCEmH91clrdx3pIpjHPCQKZtwmlb9mRy8_bW7cmvMAYkP39cwSty_eld6V-_XJbuxo5sPq6BxJF8c95vXU67vS-sDzn8iRhdeFw96N2A4clpnlffry43F-_r9efrDxdv17VnWs11qwIVIDutfWh5Dyb0rOl1y3pOe8o4FZ1hirZCgtSqNZyBdkC5kEp03Bh2Xr083p1y-r0EnO0uog_D4MaQFrRgNG-4agr4_D_wJi15LL9ZCUZxw6UuEBwhnxNiDr2dcty5vLdA7cGUPZqyxZQ9mLKsZJ6dDi_tLnR3iZOaArw4AQ69G_qDpIh3nDKicJL9A7SemdQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>619749468</pqid></control><display><type>article</type><title>Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae</title><source>ABI/INFORM Global</source><source>Springer Link</source><creator>GORSICH, S. W ; DIEN, B. S ; NICHOLS, N. N ; SLININGER, P. J ; LIU, Z. L ; SKORY, C. D</creator><creatorcontrib>GORSICH, S. W ; DIEN, B. S ; NICHOLS, N. N ; SLININGER, P. J ; LIU, Z. L ; SKORY, C. D</creatorcontrib><description>Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these genes would provide a growth benefit in the presence of furfural. Sixty two mutants were identified whose corresponding genes function in a wide spectrum of physiological pathways, suggesting that furfural tolerance is a complex process. We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes. At various concentrations of furfural and HMF, a clear association with higher sensitivity to these inhibitors was demonstrated in these mutants. PPP mutants were inefficient at reducing furfural to the less toxic furfuryl alcohol, which we propose is a result of an overall decreased abundance of reducing equivalents or to NADPH's role in stress tolerance. Overexpression of ZWF1 in S. cerevisiae allowed growth at furfural concentrations that are normally toxic. These results demonstrate a strong relationship between PPP genes and furfural tolerance and provide additional putative target genes involved in furfural tolerance.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-005-0142-3</identifier><identifier>PMID: 16222531</identifier><identifier>CODEN: AMBIDG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Biotechnology ; Carbohydrate Epimerases - genetics ; Carbohydrate Epimerases - metabolism ; Cellulose - metabolism ; Fundamental and applied biological sciences. Psychology ; Furaldehyde - analogs &amp; derivatives ; Furaldehyde - pharmacology ; Gene Expression Regulation, Fungal ; Genetics ; Glucosephosphate Dehydrogenase - genetics ; Glucosephosphate Dehydrogenase - metabolism ; Heat-Shock Response ; Lignin - metabolism ; Mutation ; Pentose Phosphate Pathway ; Proteins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - growth &amp; development ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Transketolase - genetics ; Transketolase - metabolism ; Yeast</subject><ispartof>Applied microbiology and biotechnology, 2006-07, Vol.71 (3), p.339-349</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993</citedby><cites>FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/619749468/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/619749468?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,786,790,11715,27957,27958,36095,36096,44398,75252</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17952536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16222531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GORSICH, S. W</creatorcontrib><creatorcontrib>DIEN, B. S</creatorcontrib><creatorcontrib>NICHOLS, N. N</creatorcontrib><creatorcontrib>SLININGER, P. J</creatorcontrib><creatorcontrib>LIU, Z. L</creatorcontrib><creatorcontrib>SKORY, C. D</creatorcontrib><title>Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><description>Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these genes would provide a growth benefit in the presence of furfural. Sixty two mutants were identified whose corresponding genes function in a wide spectrum of physiological pathways, suggesting that furfural tolerance is a complex process. We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes. At various concentrations of furfural and HMF, a clear association with higher sensitivity to these inhibitors was demonstrated in these mutants. PPP mutants were inefficient at reducing furfural to the less toxic furfuryl alcohol, which we propose is a result of an overall decreased abundance of reducing equivalents or to NADPH's role in stress tolerance. Overexpression of ZWF1 in S. cerevisiae allowed growth at furfural concentrations that are normally toxic. These results demonstrate a strong relationship between PPP genes and furfural tolerance and provide additional putative target genes involved in furfural tolerance.</description><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carbohydrate Epimerases - genetics</subject><subject>Carbohydrate Epimerases - metabolism</subject><subject>Cellulose - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Furaldehyde - analogs &amp; derivatives</subject><subject>Furaldehyde - pharmacology</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genetics</subject><subject>Glucosephosphate Dehydrogenase - genetics</subject><subject>Glucosephosphate Dehydrogenase - metabolism</subject><subject>Heat-Shock Response</subject><subject>Lignin - metabolism</subject><subject>Mutation</subject><subject>Pentose Phosphate Pathway</subject><subject>Proteins</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - growth &amp; development</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Transketolase - genetics</subject><subject>Transketolase - metabolism</subject><subject>Yeast</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>M0C</sourceid><recordid>eNpdkd2KFDEQRhtR3HH1AbyRIOiVranO_6Wsu6s4qOiI4E1Ip9NOlp5Om-p2mZfwmc0wAwtCUQXF-YqCU1VPgb4GStUbpLQRrKZU1BR4U7N71Qo4a2oqgd-vVhSUqJUw-qx6hHhDKTRayofVGcimKUlYVX83aQjZjT6QOZF-yaXcUMexW3zoCM45IJKIxCEmH91clrdx3pIpjHPCQKZtwmlb9mRy8_bW7cmvMAYkP39cwSty_eld6V-_XJbuxo5sPq6BxJF8c95vXU67vS-sDzn8iRhdeFw96N2A4clpnlffry43F-_r9efrDxdv17VnWs11qwIVIDutfWh5Dyb0rOl1y3pOe8o4FZ1hirZCgtSqNZyBdkC5kEp03Bh2Xr083p1y-r0EnO0uog_D4MaQFrRgNG-4agr4_D_wJi15LL9ZCUZxw6UuEBwhnxNiDr2dcty5vLdA7cGUPZqyxZQ9mLKsZJ6dDi_tLnR3iZOaArw4AQ69G_qDpIh3nDKicJL9A7SemdQ</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>GORSICH, S. W</creator><creator>DIEN, B. S</creator><creator>NICHOLS, N. N</creator><creator>SLININGER, P. J</creator><creator>LIU, Z. L</creator><creator>SKORY, C. D</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>RC3</scope></search><sort><creationdate>20060701</creationdate><title>Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae</title><author>GORSICH, S. W ; DIEN, B. S ; NICHOLS, N. N ; SLININGER, P. J ; LIU, Z. L ; SKORY, C. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Carbohydrate Epimerases - genetics</topic><topic>Carbohydrate Epimerases - metabolism</topic><topic>Cellulose - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Furaldehyde - analogs &amp; derivatives</topic><topic>Furaldehyde - pharmacology</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genetics</topic><topic>Glucosephosphate Dehydrogenase - genetics</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Heat-Shock Response</topic><topic>Lignin - metabolism</topic><topic>Mutation</topic><topic>Pentose Phosphate Pathway</topic><topic>Proteins</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - growth &amp; development</topic><topic>Saccharomyces cerevisiae Proteins - genetics</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>Transketolase - genetics</topic><topic>Transketolase - metabolism</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GORSICH, S. W</creatorcontrib><creatorcontrib>DIEN, B. S</creatorcontrib><creatorcontrib>NICHOLS, N. N</creatorcontrib><creatorcontrib>SLININGER, P. J</creatorcontrib><creatorcontrib>LIU, Z. L</creatorcontrib><creatorcontrib>SKORY, C. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Biological Sciences</collection><collection>ABI/INFORM Global</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GORSICH, S. W</au><au>DIEN, B. S</au><au>NICHOLS, N. N</au><au>SLININGER, P. J</au><au>LIU, Z. L</au><au>SKORY, C. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae</atitle><jtitle>Applied microbiology and biotechnology</jtitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>71</volume><issue>3</issue><spage>339</spage><epage>349</epage><pages>339-349</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><coden>AMBIDG</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these genes would provide a growth benefit in the presence of furfural. Sixty two mutants were identified whose corresponding genes function in a wide spectrum of physiological pathways, suggesting that furfural tolerance is a complex process. We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes. At various concentrations of furfural and HMF, a clear association with higher sensitivity to these inhibitors was demonstrated in these mutants. PPP mutants were inefficient at reducing furfural to the less toxic furfuryl alcohol, which we propose is a result of an overall decreased abundance of reducing equivalents or to NADPH's role in stress tolerance. Overexpression of ZWF1 in S. cerevisiae allowed growth at furfural concentrations that are normally toxic. These results demonstrate a strong relationship between PPP genes and furfural tolerance and provide additional putative target genes involved in furfural tolerance.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16222531</pmid><doi>10.1007/s00253-005-0142-3</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0175-7598
ispartof Applied microbiology and biotechnology, 2006-07, Vol.71 (3), p.339-349
issn 0175-7598
1432-0614
language eng
recordid cdi_proquest_miscellaneous_19842472
source ABI/INFORM Global; Springer Link
subjects Biological and medical sciences
Biotechnology
Carbohydrate Epimerases - genetics
Carbohydrate Epimerases - metabolism
Cellulose - metabolism
Fundamental and applied biological sciences. Psychology
Furaldehyde - analogs & derivatives
Furaldehyde - pharmacology
Gene Expression Regulation, Fungal
Genetics
Glucosephosphate Dehydrogenase - genetics
Glucosephosphate Dehydrogenase - metabolism
Heat-Shock Response
Lignin - metabolism
Mutation
Pentose Phosphate Pathway
Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Transketolase - genetics
Transketolase - metabolism
Yeast
title Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T03%3A17%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tolerance%20to%20furfural-induced%20stress%20is%20associated%20with%20pentose%20phosphate%20pathway%20genes%20ZWF1,%20GND1,%20RPE1,%20and%20TKL1%20in%20Saccharomyces%20cerevisiae&rft.jtitle=Applied%20microbiology%20and%20biotechnology&rft.au=GORSICH,%20S.%20W&rft.date=2006-07-01&rft.volume=71&rft.issue=3&rft.spage=339&rft.epage=349&rft.pages=339-349&rft.issn=0175-7598&rft.eissn=1432-0614&rft.coden=AMBIDG&rft_id=info:doi/10.1007/s00253-005-0142-3&rft_dat=%3Cproquest_cross%3E2087339501%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c387t-b7e0516d88ceb4f19ef32f8b3f40f03405d9370b561687b94318a1045675d4993%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=619749468&rft_id=info:pmid/16222531&rfr_iscdi=true