Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol

A novel contraceptive vaginal ring releasing etonogestrel 120 μg and ethinyl oestradiol 15 μg daily over a period of 3 weeks was tested. Each ring was used for one cycle, comprising 3 weeks of ring use followed by a 1 week ring-free period. This 1 year, multicentre study assessed the contraceptive e...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2001-03, Vol.16 (3), p.469-475
Main Authors: Roumen, F.J.M.E., Apter, D., Mulders, T.M.T., Dieben, T.O.M.
Format: Article
Language:English
Subjects:
acceptability
Biological and medical sciences
Cervix Uteri - cytology
Contraceptive Agents, Female - administration & dosage
Contraceptive Agents, Female - adverse effects
Contraceptive Agents, Female - pharmacology
Contraceptive Devices, Female - adverse effects
Contraceptive Devices, Female - standards
Desogestrel
efficacy
Estradiol Congeners - administration & dosage
Estradiol Congeners - adverse effects
Estradiol Congeners - pharmacology
Ethinyl Estradiol - administration & dosage
Ethinyl Estradiol - adverse effects
Ethinyl Estradiol - pharmacology
ethinyl oestradiol
etonogestrel
Female
Genital system. Reproduction
Humans
Medical sciences
Menstrual Cycle - drug effects
Patient Compliance
Pharmacology. Drug treatments
vaginal ring
Vinyl Compounds - administration & dosage
Vinyl Compounds - adverse effects
Vinyl Compounds - pharmacology
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Summary:A novel contraceptive vaginal ring releasing etonogestrel 120 μg and ethinyl oestradiol 15 μg daily over a period of 3 weeks was tested. Each ring was used for one cycle, comprising 3 weeks of ring use followed by a 1 week ring-free period. This 1 year, multicentre study assessed the contraceptive efficacy, cycle control, tolerability and acceptability of the contraceptive. Altogether, 1145 women were exposed to the vaginal ring for 12 109 cycles (928 woman-years). Six pregnancies occurred during treatment, giving a Pearl Index of 0.65 (95% confidence interval 0.24–1.41). Cycle control was very good, since irregular bleeding was rare (2.6–6.4% of evaluable cycles) and withdrawal bleeding (mean duration 4.7–5.3 days) occurred in 97.9–99.4% of evaluable cycles. Compliance to the prescribed regimen was high with criteria being fulfilled in 90.8% of cycles. The ring was well tolerated. The majority of women considered this new contraceptive method easy to use, and it offers an effective, convenient, well-accepted and novel method for hormonal contraception.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/16.3.469