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The efficacy of transbronchial needle aspiration with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions suspected to be lung cancer
The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs. We evaluated...
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| Published in: | Respiratory investigation 2017-11, Vol.55 (6), p.365-371 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 371 |
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| container_title | Respiratory investigation |
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| creator | Arimura, Ken Sekine, Yasuo Hiroshima, Kenzo Sato, Akitoshi Hasegawa, Mizue Katsura, Hideki Tagaya, Etsuko Kondo, Mitsuko Tamaoki, Jun |
| description | The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs.
We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS. The pathological diagnostic yields of TBNA were compared to that of TBB and brushing. The histological diagnosis of TBNA was compared to that of surgical specimens. The results of epidermal growth factor receptor (EGFR) gene mutation in TBNA samples were compared to that in TBB or surgical specimens.
The diagnostic yields of this study were 62.9% for brushing, 80.0% for TBB, and 77.1% for TBNA. Histological diagnosis was 84.8% for TBB and/or TBNA and pathological diagnosis was 86.7% for all the procedures. TBB and TBNA had significance higher than brushing (p < 0.05). TBB and TBNA had a tendency of higher diagnostic yields than brushing if EBUS probe was adjacent to PPLs (p = 0.058). Histological evaluations were obtained from TBNA specimens from 50 of 105 patients (47.6%) and these were identical to those of surgical specimens from 29 of 32 patients (90.6%). The results of EGFR gene mutation in TBNA specimens were identical to the same tissue obtained by surgery or TBB.
TBNA with EBUS-GS for PPLs was a useful tool for accurate diagnosis and EGFR gene mutation analysis. This method may improve diagnostic accuracy and be useful for molecular testing.
This study was approved by the institutional review board (Date of approval: May 27, 2013, approval number: 2816) of Tokyo Women's Medical University Hospital. |
| doi_str_mv | 10.1016/j.resinv.2017.08.004 |
| format | article |
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We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS. The pathological diagnostic yields of TBNA were compared to that of TBB and brushing. The histological diagnosis of TBNA was compared to that of surgical specimens. The results of epidermal growth factor receptor (EGFR) gene mutation in TBNA samples were compared to that in TBB or surgical specimens.
The diagnostic yields of this study were 62.9% for brushing, 80.0% for TBB, and 77.1% for TBNA. Histological diagnosis was 84.8% for TBB and/or TBNA and pathological diagnosis was 86.7% for all the procedures. TBB and TBNA had significance higher than brushing (p < 0.05). TBB and TBNA had a tendency of higher diagnostic yields than brushing if EBUS probe was adjacent to PPLs (p = 0.058). Histological evaluations were obtained from TBNA specimens from 50 of 105 patients (47.6%) and these were identical to those of surgical specimens from 29 of 32 patients (90.6%). The results of EGFR gene mutation in TBNA specimens were identical to the same tissue obtained by surgery or TBB.
TBNA with EBUS-GS for PPLs was a useful tool for accurate diagnosis and EGFR gene mutation analysis. This method may improve diagnostic accuracy and be useful for molecular testing.
This study was approved by the institutional review board (Date of approval: May 27, 2013, approval number: 2816) of Tokyo Women's Medical University Hospital.</description><identifier>ISSN: 2212-5345</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2017.08.004</identifier><identifier>PMID: 29153417</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy - methods ; Biopsy, Fine-Needle - methods ; Bronchi ; Bronchoscopy ; Endosonography - methods ; Female ; Gene mutation analysis ; Humans ; Image-Guided Biopsy - methods ; Lung - pathology ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Male ; Middle Aged ; Mutation ; Receptor, Epidermal Growth Factor - genetics ; Sensitivity and Specificity ; Transbronchial needle aspiration ; Ultrasound</subject><ispartof>Respiratory investigation, 2017-11, Vol.55 (6), p.365-371</ispartof><rights>2017 The Japanese Respiratory Society</rights><rights>Copyright © 2017 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-4057a40a0774686c8261fd15f291640f7eccdbfcfdeb80cbdbc1ca748613c8963</citedby><cites>FETCH-LOGICAL-c386t-4057a40a0774686c8261fd15f291640f7eccdbfcfdeb80cbdbc1ca748613c8963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29153417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arimura, Ken</creatorcontrib><creatorcontrib>Sekine, Yasuo</creatorcontrib><creatorcontrib>Hiroshima, Kenzo</creatorcontrib><creatorcontrib>Sato, Akitoshi</creatorcontrib><creatorcontrib>Hasegawa, Mizue</creatorcontrib><creatorcontrib>Katsura, Hideki</creatorcontrib><creatorcontrib>Tagaya, Etsuko</creatorcontrib><creatorcontrib>Kondo, Mitsuko</creatorcontrib><creatorcontrib>Tamaoki, Jun</creatorcontrib><title>The efficacy of transbronchial needle aspiration with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions suspected to be lung cancer</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs.
We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS. The pathological diagnostic yields of TBNA were compared to that of TBB and brushing. The histological diagnosis of TBNA was compared to that of surgical specimens. The results of epidermal growth factor receptor (EGFR) gene mutation in TBNA samples were compared to that in TBB or surgical specimens.
The diagnostic yields of this study were 62.9% for brushing, 80.0% for TBB, and 77.1% for TBNA. Histological diagnosis was 84.8% for TBB and/or TBNA and pathological diagnosis was 86.7% for all the procedures. TBB and TBNA had significance higher than brushing (p < 0.05). TBB and TBNA had a tendency of higher diagnostic yields than brushing if EBUS probe was adjacent to PPLs (p = 0.058). Histological evaluations were obtained from TBNA specimens from 50 of 105 patients (47.6%) and these were identical to those of surgical specimens from 29 of 32 patients (90.6%). The results of EGFR gene mutation in TBNA specimens were identical to the same tissue obtained by surgery or TBB.
TBNA with EBUS-GS for PPLs was a useful tool for accurate diagnosis and EGFR gene mutation analysis. This method may improve diagnostic accuracy and be useful for molecular testing.
This study was approved by the institutional review board (Date of approval: May 27, 2013, approval number: 2816) of Tokyo Women's Medical University Hospital.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy - methods</subject><subject>Biopsy, Fine-Needle - methods</subject><subject>Bronchi</subject><subject>Bronchoscopy</subject><subject>Endosonography - methods</subject><subject>Female</subject><subject>Gene mutation analysis</subject><subject>Humans</subject><subject>Image-Guided Biopsy - methods</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Sensitivity and Specificity</subject><subject>Transbronchial needle aspiration</subject><subject>Ultrasound</subject><issn>2212-5345</issn><issn>2212-5353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu3CAQhlHVKImSvEFUcexlXbAx9l4qVVHTVorUS3pGeBjWrFhwwaTaB-p7lmjT9FYuIPF_M_PPT8gtZw1nXH7YNwmzC09Ny_jQsLFhTLwhl23L203f9d3b17foL8hNzntWj-xbweU5uWi3vP7w4ZL8fpyRorUONBxptHRNOuQpxQCz054GROOR6ry4pFcXA_3l1pliMPGfqPhK5RjiLullPtJSR9tRTXfFGaR5Rl0RGxNdMLllxlSZpfhDDDodqa9OYsg0l7wgrGjoGumE1JdaBHQATNfkzGqf8eblviI_7j8_3n3dPHz_8u3u08MGulGuG8H6QQum2TAIOUoYW8mt4b2tfqVgdkAAM1mwBqeRwWQm4KAHMUrewbiV3RV5f6q7pPizYF7VwWVA73XAWLLiWymF6MXQVak4SSHFnBNatSR3qH4UZ-o5I7VXp4zUc0aKjapmVLF3Lx3KdEDzCv1NpAo-ngRYfT45TCqDw7oE41LdjjLR_b_DH-I3qao</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Arimura, Ken</creator><creator>Sekine, Yasuo</creator><creator>Hiroshima, Kenzo</creator><creator>Sato, Akitoshi</creator><creator>Hasegawa, Mizue</creator><creator>Katsura, Hideki</creator><creator>Tagaya, Etsuko</creator><creator>Kondo, Mitsuko</creator><creator>Tamaoki, Jun</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>The efficacy of transbronchial needle aspiration with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions suspected to be lung cancer</title><author>Arimura, Ken ; Sekine, Yasuo ; Hiroshima, Kenzo ; Sato, Akitoshi ; Hasegawa, Mizue ; Katsura, Hideki ; Tagaya, Etsuko ; Kondo, Mitsuko ; Tamaoki, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-4057a40a0774686c8261fd15f291640f7eccdbfcfdeb80cbdbc1ca748613c8963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy - methods</topic><topic>Biopsy, Fine-Needle - methods</topic><topic>Bronchi</topic><topic>Bronchoscopy</topic><topic>Endosonography - methods</topic><topic>Female</topic><topic>Gene mutation analysis</topic><topic>Humans</topic><topic>Image-Guided Biopsy - methods</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Sensitivity and Specificity</topic><topic>Transbronchial needle aspiration</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arimura, Ken</creatorcontrib><creatorcontrib>Sekine, Yasuo</creatorcontrib><creatorcontrib>Hiroshima, Kenzo</creatorcontrib><creatorcontrib>Sato, Akitoshi</creatorcontrib><creatorcontrib>Hasegawa, Mizue</creatorcontrib><creatorcontrib>Katsura, Hideki</creatorcontrib><creatorcontrib>Tagaya, Etsuko</creatorcontrib><creatorcontrib>Kondo, Mitsuko</creatorcontrib><creatorcontrib>Tamaoki, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arimura, Ken</au><au>Sekine, Yasuo</au><au>Hiroshima, Kenzo</au><au>Sato, Akitoshi</au><au>Hasegawa, Mizue</au><au>Katsura, Hideki</au><au>Tagaya, Etsuko</au><au>Kondo, Mitsuko</au><au>Tamaoki, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of transbronchial needle aspiration with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions suspected to be lung cancer</atitle><jtitle>Respiratory investigation</jtitle><addtitle>Respir Investig</addtitle><date>2017-11</date><risdate>2017</risdate><volume>55</volume><issue>6</issue><spage>365</spage><epage>371</epage><pages>365-371</pages><issn>2212-5345</issn><eissn>2212-5353</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs.
We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS. The pathological diagnostic yields of TBNA were compared to that of TBB and brushing. The histological diagnosis of TBNA was compared to that of surgical specimens. The results of epidermal growth factor receptor (EGFR) gene mutation in TBNA samples were compared to that in TBB or surgical specimens.
The diagnostic yields of this study were 62.9% for brushing, 80.0% for TBB, and 77.1% for TBNA. Histological diagnosis was 84.8% for TBB and/or TBNA and pathological diagnosis was 86.7% for all the procedures. TBB and TBNA had significance higher than brushing (p < 0.05). TBB and TBNA had a tendency of higher diagnostic yields than brushing if EBUS probe was adjacent to PPLs (p = 0.058). Histological evaluations were obtained from TBNA specimens from 50 of 105 patients (47.6%) and these were identical to those of surgical specimens from 29 of 32 patients (90.6%). The results of EGFR gene mutation in TBNA specimens were identical to the same tissue obtained by surgery or TBB.
TBNA with EBUS-GS for PPLs was a useful tool for accurate diagnosis and EGFR gene mutation analysis. This method may improve diagnostic accuracy and be useful for molecular testing.
This study was approved by the institutional review board (Date of approval: May 27, 2013, approval number: 2816) of Tokyo Women's Medical University Hospital.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29153417</pmid><doi>10.1016/j.resinv.2017.08.004</doi><tpages>7</tpages></addata></record> |
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| ispartof | Respiratory investigation, 2017-11, Vol.55 (6), p.365-371 |
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| subjects | Adult Aged Aged, 80 and over Biopsy - methods Biopsy, Fine-Needle - methods Bronchi Bronchoscopy Endosonography - methods Female Gene mutation analysis Humans Image-Guided Biopsy - methods Lung - pathology Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Receptor, Epidermal Growth Factor - genetics Sensitivity and Specificity Transbronchial needle aspiration Ultrasound |
| title | The efficacy of transbronchial needle aspiration with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions suspected to be lung cancer |
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