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Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study
The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls. The histopathological characteristics of IFPs were e...
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| Published in: | Rheumatology (Oxford, England) England), 2017-10, Vol.56 (10), p.1784-1793 |
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| creator | Favero, Marta El-Hadi, Hamza Belluzzi, Elisa Granzotto, Marnie Porzionato, Andrea Sarasin, Gloria Rambaldo, Anna Iacobellis, Claudio Cigolotti, Augusto Fontanella, Chiara Giulia Natali, Arturo Ramonda, Roberta Ruggieri, Pietro De Caro, Raffaele Vettor, Roberto Rossato, Marco Macchi, Veronica |
| description | The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls.
The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa. Immunohistochemistry was performed to evaluate VEGF, monocyte chemotactic protein 1 (MCP-1) and IL-6 proteins. Quantitative real time PCR was performed to evaluate the expression levels of adipocytokines in the OA IFPs.
OA IFPs showed an increase in inflammatory infiltration, vascularization and thickness of the interlobular septa compared with controls. VEGF, MCP-1 and IL-6 proteins were higher in OA IFPs compared with in controls. Inflammatory infiltration, hyperplasia, vascularization and fibrosis were increased in OA IFP synovial membranes compared with in those of controls. VEGF protein levels were associated with an increased number of vessels in the OA IFPs, while MCP-1 and IL-6 protein levels were associated with higher grades of inflammatory infiltration. Leptin levels were positively correlated with adiponectin and MCP-1expression, while adiponectin positively correlated with peroxisome proliferative activated receptor gamma, MCP-1 and IFP vascularity. MCP-1 showed a positive correlation with peroxisome proliferative activated receptor gamma. IFP lobules dimensions were positively correlated with IL-6 expression and negatively with thickness of interlobular septa. VEGF mRNA levels were positively correlated with increased synovial vascularity.
OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA). |
| doi_str_mv | 10.1093/rheumatology/kex287 |
| format | article |
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The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa. Immunohistochemistry was performed to evaluate VEGF, monocyte chemotactic protein 1 (MCP-1) and IL-6 proteins. Quantitative real time PCR was performed to evaluate the expression levels of adipocytokines in the OA IFPs.
OA IFPs showed an increase in inflammatory infiltration, vascularization and thickness of the interlobular septa compared with controls. VEGF, MCP-1 and IL-6 proteins were higher in OA IFPs compared with in controls. Inflammatory infiltration, hyperplasia, vascularization and fibrosis were increased in OA IFP synovial membranes compared with in those of controls. VEGF protein levels were associated with an increased number of vessels in the OA IFPs, while MCP-1 and IL-6 protein levels were associated with higher grades of inflammatory infiltration. Leptin levels were positively correlated with adiponectin and MCP-1expression, while adiponectin positively correlated with peroxisome proliferative activated receptor gamma, MCP-1 and IFP vascularity. MCP-1 showed a positive correlation with peroxisome proliferative activated receptor gamma. IFP lobules dimensions were positively correlated with IL-6 expression and negatively with thickness of interlobular septa. VEGF mRNA levels were positively correlated with increased synovial vascularity.
OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA).</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kex287</identifier><identifier>PMID: 28957567</identifier><language>eng</language><publisher>England</publisher><subject>Adipokines - analysis ; Adiponectin - analysis ; Adipose Tissue - blood supply ; Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee ; Case-Control Studies ; Chemokine CCL2 - analysis ; Female ; Humans ; Interleukin-6 - analysis ; Knee Joint - blood supply ; Knee Joint - metabolism ; Knee Joint - pathology ; Male ; Middle Aged ; Osteoarthritis, Knee - metabolism ; Osteoarthritis, Knee - pathology ; Osteoarthritis, Knee - surgery ; Patella - blood supply ; Patella - metabolism ; Patella - pathology ; Synovial Membrane - blood supply ; Synovial Membrane - metabolism ; Synovial Membrane - pathology ; Vascular Endothelial Growth Factor A - analysis</subject><ispartof>Rheumatology (Oxford, England), 2017-10, Vol.56 (10), p.1784-1793</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-794fac2393abbaf52086e7a73d768596821cdf41e6502de7575085aae1550a0c3</citedby><cites>FETCH-LOGICAL-c416t-794fac2393abbaf52086e7a73d768596821cdf41e6502de7575085aae1550a0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28957567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Favero, Marta</creatorcontrib><creatorcontrib>El-Hadi, Hamza</creatorcontrib><creatorcontrib>Belluzzi, Elisa</creatorcontrib><creatorcontrib>Granzotto, Marnie</creatorcontrib><creatorcontrib>Porzionato, Andrea</creatorcontrib><creatorcontrib>Sarasin, Gloria</creatorcontrib><creatorcontrib>Rambaldo, Anna</creatorcontrib><creatorcontrib>Iacobellis, Claudio</creatorcontrib><creatorcontrib>Cigolotti, Augusto</creatorcontrib><creatorcontrib>Fontanella, Chiara Giulia</creatorcontrib><creatorcontrib>Natali, Arturo</creatorcontrib><creatorcontrib>Ramonda, Roberta</creatorcontrib><creatorcontrib>Ruggieri, Pietro</creatorcontrib><creatorcontrib>De Caro, Raffaele</creatorcontrib><creatorcontrib>Vettor, Roberto</creatorcontrib><creatorcontrib>Rossato, Marco</creatorcontrib><creatorcontrib>Macchi, Veronica</creatorcontrib><title>Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls.
The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa. Immunohistochemistry was performed to evaluate VEGF, monocyte chemotactic protein 1 (MCP-1) and IL-6 proteins. Quantitative real time PCR was performed to evaluate the expression levels of adipocytokines in the OA IFPs.
OA IFPs showed an increase in inflammatory infiltration, vascularization and thickness of the interlobular septa compared with controls. VEGF, MCP-1 and IL-6 proteins were higher in OA IFPs compared with in controls. Inflammatory infiltration, hyperplasia, vascularization and fibrosis were increased in OA IFP synovial membranes compared with in those of controls. VEGF protein levels were associated with an increased number of vessels in the OA IFPs, while MCP-1 and IL-6 protein levels were associated with higher grades of inflammatory infiltration. Leptin levels were positively correlated with adiponectin and MCP-1expression, while adiponectin positively correlated with peroxisome proliferative activated receptor gamma, MCP-1 and IFP vascularity. MCP-1 showed a positive correlation with peroxisome proliferative activated receptor gamma. IFP lobules dimensions were positively correlated with IL-6 expression and negatively with thickness of interlobular septa. VEGF mRNA levels were positively correlated with increased synovial vascularity.
OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA).</description><subject>Adipokines - analysis</subject><subject>Adiponectin - analysis</subject><subject>Adipose Tissue - blood supply</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthroplasty, Replacement, Knee</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - analysis</subject><subject>Knee Joint - blood supply</subject><subject>Knee Joint - metabolism</subject><subject>Knee Joint - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis, Knee - metabolism</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Patella - blood supply</subject><subject>Patella - metabolism</subject><subject>Patella - pathology</subject><subject>Synovial Membrane - blood supply</subject><subject>Synovial Membrane - metabolism</subject><subject>Synovial Membrane - pathology</subject><subject>Vascular Endothelial Growth Factor A - analysis</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpNkDtPwzAQxy0EoqXwCZCQR5ZQP-LYYUMVj0qVWGBgiq6OTQJJHGxHot-eRC2I6W74P-5-CF1SckNJzpe-MkML0TXufbf8NN9MySM0p2nGEsI5O_7bWTpDZyF8EEIE5eoUzZjKhRSZnKO3dWc99BBN04DHFiLuocTWQBy8CbjusAvROPCx8nWswy0GXNUhutFTTd21hgZDV-LWNUYPU0qIQ7k7RycWmmAuDnOBXh_uX1ZPyeb5cb262yQ6pVlMZJ5a0IznHLZbsIIRlRkJkpcyUyLPFKO6tCk1mSCsNHK8mygBYKgQBIjmC3S9z-29-xpMiEVbBz290xk3hILmqWBUcMVGKd9LtXcheGOL3tct-F1BSTExLf4zLfZMR9fVoWDYtqb88_xC5D9TRXjs</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Favero, Marta</creator><creator>El-Hadi, Hamza</creator><creator>Belluzzi, Elisa</creator><creator>Granzotto, Marnie</creator><creator>Porzionato, Andrea</creator><creator>Sarasin, Gloria</creator><creator>Rambaldo, Anna</creator><creator>Iacobellis, Claudio</creator><creator>Cigolotti, Augusto</creator><creator>Fontanella, Chiara Giulia</creator><creator>Natali, Arturo</creator><creator>Ramonda, Roberta</creator><creator>Ruggieri, Pietro</creator><creator>De Caro, Raffaele</creator><creator>Vettor, Roberto</creator><creator>Rossato, Marco</creator><creator>Macchi, Veronica</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study</title><author>Favero, Marta ; El-Hadi, Hamza ; Belluzzi, Elisa ; Granzotto, Marnie ; Porzionato, Andrea ; Sarasin, Gloria ; Rambaldo, Anna ; Iacobellis, Claudio ; Cigolotti, Augusto ; Fontanella, Chiara Giulia ; Natali, Arturo ; Ramonda, Roberta ; Ruggieri, Pietro ; De Caro, Raffaele ; Vettor, Roberto ; Rossato, Marco ; Macchi, Veronica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-794fac2393abbaf52086e7a73d768596821cdf41e6502de7575085aae1550a0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipokines - analysis</topic><topic>Adiponectin - analysis</topic><topic>Adipose Tissue - blood supply</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthroplasty, Replacement, Knee</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - analysis</topic><topic>Knee Joint - blood supply</topic><topic>Knee Joint - metabolism</topic><topic>Knee Joint - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis, Knee - metabolism</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Patella - blood supply</topic><topic>Patella - metabolism</topic><topic>Patella - pathology</topic><topic>Synovial Membrane - blood supply</topic><topic>Synovial Membrane - metabolism</topic><topic>Synovial Membrane - pathology</topic><topic>Vascular Endothelial Growth Factor A - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Favero, Marta</creatorcontrib><creatorcontrib>El-Hadi, Hamza</creatorcontrib><creatorcontrib>Belluzzi, Elisa</creatorcontrib><creatorcontrib>Granzotto, Marnie</creatorcontrib><creatorcontrib>Porzionato, Andrea</creatorcontrib><creatorcontrib>Sarasin, Gloria</creatorcontrib><creatorcontrib>Rambaldo, Anna</creatorcontrib><creatorcontrib>Iacobellis, Claudio</creatorcontrib><creatorcontrib>Cigolotti, Augusto</creatorcontrib><creatorcontrib>Fontanella, Chiara Giulia</creatorcontrib><creatorcontrib>Natali, Arturo</creatorcontrib><creatorcontrib>Ramonda, Roberta</creatorcontrib><creatorcontrib>Ruggieri, Pietro</creatorcontrib><creatorcontrib>De Caro, Raffaele</creatorcontrib><creatorcontrib>Vettor, Roberto</creatorcontrib><creatorcontrib>Rossato, Marco</creatorcontrib><creatorcontrib>Macchi, Veronica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Favero, Marta</au><au>El-Hadi, Hamza</au><au>Belluzzi, Elisa</au><au>Granzotto, Marnie</au><au>Porzionato, Andrea</au><au>Sarasin, Gloria</au><au>Rambaldo, Anna</au><au>Iacobellis, Claudio</au><au>Cigolotti, Augusto</au><au>Fontanella, Chiara Giulia</au><au>Natali, Arturo</au><au>Ramonda, Roberta</au><au>Ruggieri, Pietro</au><au>De Caro, Raffaele</au><au>Vettor, Roberto</au><au>Rossato, Marco</au><au>Macchi, Veronica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>56</volume><issue>10</issue><spage>1784</spage><epage>1793</epage><pages>1784-1793</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls.
The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa. Immunohistochemistry was performed to evaluate VEGF, monocyte chemotactic protein 1 (MCP-1) and IL-6 proteins. Quantitative real time PCR was performed to evaluate the expression levels of adipocytokines in the OA IFPs.
OA IFPs showed an increase in inflammatory infiltration, vascularization and thickness of the interlobular septa compared with controls. VEGF, MCP-1 and IL-6 proteins were higher in OA IFPs compared with in controls. Inflammatory infiltration, hyperplasia, vascularization and fibrosis were increased in OA IFP synovial membranes compared with in those of controls. VEGF protein levels were associated with an increased number of vessels in the OA IFPs, while MCP-1 and IL-6 protein levels were associated with higher grades of inflammatory infiltration. Leptin levels were positively correlated with adiponectin and MCP-1expression, while adiponectin positively correlated with peroxisome proliferative activated receptor gamma, MCP-1 and IFP vascularity. MCP-1 showed a positive correlation with peroxisome proliferative activated receptor gamma. IFP lobules dimensions were positively correlated with IL-6 expression and negatively with thickness of interlobular septa. VEGF mRNA levels were positively correlated with increased synovial vascularity.
OA IFPs and synovial membranes are more inflamed, vascularized and fibrous compared with those of control patients (without OA).</abstract><cop>England</cop><pmid>28957567</pmid><doi>10.1093/rheumatology/kex287</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals - Connect here FIRST to enable access; Alma/SFX Local Collection |
| subjects | Adipokines - analysis Adiponectin - analysis Adipose Tissue - blood supply Adipose Tissue - metabolism Adipose Tissue - pathology Aged Aged, 80 and over Arthroplasty, Replacement, Knee Case-Control Studies Chemokine CCL2 - analysis Female Humans Interleukin-6 - analysis Knee Joint - blood supply Knee Joint - metabolism Knee Joint - pathology Male Middle Aged Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Osteoarthritis, Knee - surgery Patella - blood supply Patella - metabolism Patella - pathology Synovial Membrane - blood supply Synovial Membrane - metabolism Synovial Membrane - pathology Vascular Endothelial Growth Factor A - analysis |
| title | Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study |
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