super(13)C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2- trimethyl-propyl) ester

Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2- propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly super(13)C-labeled analogue to identify, and consequently prevent, metabolically labile position...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (4), p.969-973
Main Authors: Micheli, Fabrizio, Cavanni, Paolo, Di Fabio, Romano, Donati, Daniele, Hamdan, Mahmoud, Provera, Stefano, Tranquillini, Maria Elvira, Vitulli, Giovanni
Format: Article
Language:English
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Summary:Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2- propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly super(13)C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.039