Urinary Mitochondrial DNA Level as a Biomarker of Acute Kidney Injury Severity

Background: Mitochondrial dysfunction contributes to the pathogenesis of acute kidney injury (AKI). The urinary mitochondrial DNA (mtDNA) level was previously shown to predict renal function recovery in AKI following cardiac surgery. Herein, we determine whether urinary mtDNA is a marker of severity...

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Published in:Kidney diseases 2017-07, Vol.3 (2), p.78-83
Main Authors: Ho, Phoebe Wing-Lam, Pang, Wing-Fai, Luk, Cathy Choi-Wan, Ng, Jack Kit-Chung, Chow, Kai-Ming, Kwan, Bonnie Ching-Ha, Li, Philip Kam-Tao, Szeto, Cheuk-Chun
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container_end_page 83
container_issue 2
container_start_page 78
container_title Kidney diseases
container_volume 3
creator Ho, Phoebe Wing-Lam
Pang, Wing-Fai
Luk, Cathy Choi-Wan
Ng, Jack Kit-Chung
Chow, Kai-Ming
Kwan, Bonnie Ching-Ha
Li, Philip Kam-Tao
Szeto, Cheuk-Chun
description Background: Mitochondrial dysfunction contributes to the pathogenesis of acute kidney injury (AKI). The urinary mitochondrial DNA (mtDNA) level was previously shown to predict renal function recovery in AKI following cardiac surgery. Herein, we determine whether urinary mtDNA is a marker of severity and predictor of recovery in AKI due to other etiologies. Methods: We recruited 107 AKI patients. The urinary mtDNA level was measured, the severity of AKI was quantified, and patients were followed for 90 days. Results: The urinary mtDNA level had modest but statistically significant correlations with the peak serum creatinine level (Spearman's r = -0.248, p = 0.010) and the duration of hospital stay (r = -0.217, p = 0.025). Patients who required temporary dialysis also tended to have higher urinary mtDNA levels than those without dialysis (22.6 ± 4.5 vs. 24.9 ± 5.7 cycles, p = 0.06). There was no definite relation between the urinary mtDNA level and renal function recovery. Conclusion: The urinary mtDNA level is a marker of AKI severity, as reflected by its significant correlation with the peak serum creatinine level, duration of hospital stay, and probably the need for temporary dialysis. Our result suggests that urinary mtDNA has the potential to serve as a biomarker of AKI.
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The urinary mitochondrial DNA (mtDNA) level was previously shown to predict renal function recovery in AKI following cardiac surgery. Herein, we determine whether urinary mtDNA is a marker of severity and predictor of recovery in AKI due to other etiologies. Methods: We recruited 107 AKI patients. The urinary mtDNA level was measured, the severity of AKI was quantified, and patients were followed for 90 days. Results: The urinary mtDNA level had modest but statistically significant correlations with the peak serum creatinine level (Spearman's r = -0.248, p = 0.010) and the duration of hospital stay (r = -0.217, p = 0.025). Patients who required temporary dialysis also tended to have higher urinary mtDNA levels than those without dialysis (22.6 ± 4.5 vs. 24.9 ± 5.7 cycles, p = 0.06). There was no definite relation between the urinary mtDNA level and renal function recovery. 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title Urinary Mitochondrial DNA Level as a Biomarker of Acute Kidney Injury Severity
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