Effectiveness of Isoniazid Treatment for Latent Tuberculosis Infection among Human Immunodeficiency Virus (HIV)–Infected and HIV–Uninfected Injection Drug Users in Methadone Programs

Injection drug users (IDUs) were heavily affected by the tuberculosis (TB) resurgence in New York City in the 1990s. We assessed the effectiveness of screening for latent TB infection in methadone users and of selective treatment with isoniazid. Risk for future TB was classified as low or high on th...

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Bibliographic Details
Published in:Clinical infectious diseases 2003-12, Vol.37 (12), p.1686-1692
Main Authors: Scholten, Jerod N., Driver, Cynthia R., Munsiff, Sonal S., Kaye, Katherine, Rubino, Mary Ann, Gourevitch, Marc N., Trim, Caroline, Amofa, James, Seewald, Randy, Highley, Esther, Fujiwara, Paula I.
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS-Related Opportunistic Infections - drug therapy
Antitubercular Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
CD4 antigen
Cutaneous tuberculosis
Disease risk
Female
HIV
HIV Infections - complications
HIV/AIDS
Human bacterial diseases
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Isoniazid - therapeutic use
Latent tuberculosis
Male
Medical sciences
Methadone
Methadone - therapeutic use
Middle Aged
Mycobacterium tuberculosis
Preventive medicine
Risk Factors
Substance Abuse, Intravenous - drug therapy
T lymphocytes
Treatment Outcome
Tuberculin
Tuberculin Test
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis and atypical mycobacterial infections
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Injection drug users (IDUs) were heavily affected by the tuberculosis (TB) resurgence in New York City in the 1990s. We assessed the effectiveness of screening for latent TB infection in methadone users and of selective treatment with isoniazid. Risk for future TB was classified as low or high on the basis of tuberculin, anergy, and HIV test results. The cohort of 2212 IDUs was followed up for a median of 4.2 years; 25 IDUs, of whom 20 (80%) were infected with human immunodeficiency virus (HIV), developed TB. In an adjusted Cox proportional hazards model of high-risk IDUs, the risk of TB was associated with HIV infection (HR 10.3; 95% CI, 3.4–31.3); receipt of
ISSN:1058-4838
1537-6591
DOI:10.1086/379513