Association Between Waist-to-Height Ratio and Endothelial Dysfunction in Patients With Morbidity　― A Report From the FMD-J Study

Background:Waist circumference (WC), waist-to-height ratio (WHtR) and body mass index (BMI) are known as easy anthropometric markers of abnormal obesity and screening tools for predicting cardiovascular outcomes, but which indices are best is unclear. We therefore investigated the superiority and as...

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Published in:Circulation Journal 2017/11/24, Vol.81(12), pp.1911-1918
Main Authors: Tokushige, Akihiro, Ueda, Shinichiro, Tomiyama, Hirofumi, Ohishi, Mituru, Kohro, Takahide, Higashi, Yukihito, Takase, Bonpei, Suzuki, Toru, Ishizu, Tomoko, Yamazaki, Tsutomu, Furumoto, Tomoo, Kario, Kazuomi, Inoue, Teruo, Koba, Shinji, Takemoto, Yasuhiko, Hano, Takuzo, Sata, Masataka, Ishibashi, Yutaka, Node, Koichi, Maemura, Koji, Ohya, Yusuke, Furukawa, Taiji, Ito, Hiroshi, Yamashina, Akira
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Language:English
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Body mass index
Endothelial dysfunction
Flow-mediated vasodilatation
Waist circumference
Waist-to-height ratio
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cited_by cdi_FETCH-LOGICAL-c495t-6fb54cb2b6a000ad20367c7ae73c9b7e27da7b5caba40967cd69682d77f85bd63
cites cdi_FETCH-LOGICAL-c495t-6fb54cb2b6a000ad20367c7ae73c9b7e27da7b5caba40967cd69682d77f85bd63
container_end_page 1918
container_issue 12
container_start_page 1911
container_title Circulation Journal
container_volume 81
creator Tokushige, Akihiro
Ueda, Shinichiro
Tomiyama, Hirofumi
Ohishi, Mituru
Kohro, Takahide
Higashi, Yukihito
Takase, Bonpei
Suzuki, Toru
Ishizu, Tomoko
Yamazaki, Tsutomu
Furumoto, Tomoo
Kario, Kazuomi
Inoue, Teruo
Koba, Shinji
Takemoto, Yasuhiko
Hano, Takuzo
Sata, Masataka
Ishibashi, Yutaka
Node, Koichi
Maemura, Koji
Ohya, Yusuke
Furukawa, Taiji
Ito, Hiroshi
Yamashina, Akira
description Background:Waist circumference (WC), waist-to-height ratio (WHtR) and body mass index (BMI) are known as easy anthropometric markers of abnormal obesity and screening tools for predicting cardiovascular outcomes, but which indices are best is unclear. We therefore investigated the superiority and association between each index and low flow-mediated dilatation (FMD) as a surrogate marker for cardiovascular outcomes in patients with morbidity in a large Japanese prospective cohort.Methods and Results:A total of 1,645 Japanese patients who had coronary artery disease and hypertension or diabetes mellitus were enrolled, and 1,087 of them were analyzed. The high-WHtR group (≥0.5) showed greater morbidity and increased inflammation in association with atherosclerosis compared with the low-WHtR group. High WHtR and advanced age were identified as predictors of low FMD (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.02–1.88, P=0.037 and OR 1.55, 95% CI 1.19–2.01, P=0.001, respectively). However, WC was not associated with that risk in either sex (male: OR 1.37, 95% CI 0.97–1.93, P=0.076; female: OR 1.08, 95% CI 0.68–1.73, P=0.74), and no association was evident between high BMI and low FMD (OR 0.92, 95% CI 0.71–1.19, P=0.54).Conclusions:WHtR offers a superior predictor of decreased FMD than other anthropometric indices, and progression of arteriosclerosis might be detected more sensitively. Further study is needed to investigate the relationship between cardiovascular mortality and WHtR.
doi_str_mv 10.1253/circj.CJ-17-0211
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We therefore investigated the superiority and association between each index and low flow-mediated dilatation (FMD) as a surrogate marker for cardiovascular outcomes in patients with morbidity in a large Japanese prospective cohort.Methods and Results:A total of 1,645 Japanese patients who had coronary artery disease and hypertension or diabetes mellitus were enrolled, and 1,087 of them were analyzed. The high-WHtR group (≥0.5) showed greater morbidity and increased inflammation in association with atherosclerosis compared with the low-WHtR group. High WHtR and advanced age were identified as predictors of low FMD (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.02–1.88, P=0.037 and OR 1.55, 95% CI 1.19–2.01, P=0.001, respectively). However, WC was not associated with that risk in either sex (male: OR 1.37, 95% CI 0.97–1.93, P=0.076; female: OR 1.08, 95% CI 0.68–1.73, P=0.74), and no association was evident between high BMI and low FMD (OR 0.92, 95% CI 0.71–1.19, P=0.54).Conclusions:WHtR offers a superior predictor of decreased FMD than other anthropometric indices, and progression of arteriosclerosis might be detected more sensitively. Further study is needed to investigate the relationship between cardiovascular mortality and WHtR.</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-17-0211</identifier><identifier>PMID: 28690284</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Body mass index ; Endothelial dysfunction ; Flow-mediated vasodilatation ; Waist circumference ; Waist-to-height ratio</subject><ispartof>Circulation Journal, 2017/11/24, Vol.81(12), pp.1911-1918</ispartof><rights>2017 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-6fb54cb2b6a000ad20367c7ae73c9b7e27da7b5caba40967cd69682d77f85bd63</citedby><cites>FETCH-LOGICAL-c495t-6fb54cb2b6a000ad20367c7ae73c9b7e27da7b5caba40967cd69682d77f85bd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28690284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokushige, Akihiro</creatorcontrib><creatorcontrib>Ueda, Shinichiro</creatorcontrib><creatorcontrib>Tomiyama, Hirofumi</creatorcontrib><creatorcontrib>Ohishi, Mituru</creatorcontrib><creatorcontrib>Kohro, Takahide</creatorcontrib><creatorcontrib>Higashi, Yukihito</creatorcontrib><creatorcontrib>Takase, Bonpei</creatorcontrib><creatorcontrib>Suzuki, Toru</creatorcontrib><creatorcontrib>Ishizu, Tomoko</creatorcontrib><creatorcontrib>Yamazaki, Tsutomu</creatorcontrib><creatorcontrib>Furumoto, Tomoo</creatorcontrib><creatorcontrib>Kario, Kazuomi</creatorcontrib><creatorcontrib>Inoue, Teruo</creatorcontrib><creatorcontrib>Koba, Shinji</creatorcontrib><creatorcontrib>Takemoto, Yasuhiko</creatorcontrib><creatorcontrib>Hano, Takuzo</creatorcontrib><creatorcontrib>Sata, Masataka</creatorcontrib><creatorcontrib>Ishibashi, Yutaka</creatorcontrib><creatorcontrib>Node, Koichi</creatorcontrib><creatorcontrib>Maemura, Koji</creatorcontrib><creatorcontrib>Ohya, Yusuke</creatorcontrib><creatorcontrib>Furukawa, Taiji</creatorcontrib><creatorcontrib>Ito, Hiroshi</creatorcontrib><creatorcontrib>Yamashina, Akira</creatorcontrib><title>Association Between Waist-to-Height Ratio and Endothelial Dysfunction in Patients With Morbidity　― A Report From the FMD-J Study</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:Waist circumference (WC), waist-to-height ratio (WHtR) and body mass index (BMI) are known as easy anthropometric markers of abnormal obesity and screening tools for predicting cardiovascular outcomes, but which indices are best is unclear. We therefore investigated the superiority and association between each index and low flow-mediated dilatation (FMD) as a surrogate marker for cardiovascular outcomes in patients with morbidity in a large Japanese prospective cohort.Methods and Results:A total of 1,645 Japanese patients who had coronary artery disease and hypertension or diabetes mellitus were enrolled, and 1,087 of them were analyzed. The high-WHtR group (≥0.5) showed greater morbidity and increased inflammation in association with atherosclerosis compared with the low-WHtR group. High WHtR and advanced age were identified as predictors of low FMD (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.02–1.88, P=0.037 and OR 1.55, 95% CI 1.19–2.01, P=0.001, respectively). However, WC was not associated with that risk in either sex (male: OR 1.37, 95% CI 0.97–1.93, P=0.076; female: OR 1.08, 95% CI 0.68–1.73, P=0.74), and no association was evident between high BMI and low FMD (OR 0.92, 95% CI 0.71–1.19, P=0.54).Conclusions:WHtR offers a superior predictor of decreased FMD than other anthropometric indices, and progression of arteriosclerosis might be detected more sensitively. 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source Medical Journals
subjects Body mass index
Endothelial dysfunction
Flow-mediated vasodilatation
Waist circumference
Waist-to-height ratio
title Association Between Waist-to-Height Ratio and Endothelial Dysfunction in Patients With Morbidity　― A Report From the FMD-J Study
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