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Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus
In efforts to find new antimicrobial peptides (AMPs), we studied the skin secretion of the endemic Colombian frog Dendropsophus columbianus belonging to a genus that has not been investigated previously. From HPLC-fractionated secretion, we identified one peptide with slightly antibacterial activity...
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| Published in: | Natural product research 2018-06, Vol.32 (12), p.1383-1389 |
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| creator | Triana-Vidal, Luz Elena Castro, Mariana Souza Pires Júnior, Osmindo Rodrigues Álvares, Alice Cunha Morales de Freitas, Sonia Maria Fontes, Wagner Vargas, Jimmy Alexander Guerrero Zúñiga-Baos, Jorge Alberto Correia Batista, Isabel de Fátima Grellier, Philippe Charneau, Sébastien |
| description | In efforts to find new antimicrobial peptides (AMPs), we studied the skin secretion of the endemic Colombian frog Dendropsophus columbianus belonging to a genus that has not been investigated previously. From HPLC-fractionated secretion, we identified one peptide with slightly antibacterial activity. Its peptide sequence showed no sequence similarity to current annotated peptides. We named this novel peptide dendropsophin 1 (Dc1). Afterward, two analogues were designed (Dc1.1 and Dc1.2) to improve the cationic and amphipathic features. Then, their antiproliferative and cytotoxic properties were evaluated against several pathogens including bacteria, fungi, protozoa and also mammalian cells. Dc1 and its two analogues exhibited moderate antibacterial activities and no hemolytic and cytotoxic effects on mammalian cells. Analogue Dc1.2 showed slightly improved antibacterial properties. Their secondary structures were characterised using CD spectroscopy and Dc1.2 displayed a higher α-helix content and thermal stability compared to Dc1 and Dc1.1 in hydrophobic experimental conditions. |
| doi_str_mv | 10.1080/14786419.2017.1346646 |
| format | article |
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From HPLC-fractionated secretion, we identified one peptide with slightly antibacterial activity. Its peptide sequence showed no sequence similarity to current annotated peptides. We named this novel peptide dendropsophin 1 (Dc1). Afterward, two analogues were designed (Dc1.1 and Dc1.2) to improve the cationic and amphipathic features. Then, their antiproliferative and cytotoxic properties were evaluated against several pathogens including bacteria, fungi, protozoa and also mammalian cells. Dc1 and its two analogues exhibited moderate antibacterial activities and no hemolytic and cytotoxic effects on mammalian cells. Analogue Dc1.2 showed slightly improved antibacterial properties. Their secondary structures were characterised using CD spectroscopy and Dc1.2 displayed a higher α-helix content and thermal stability compared to Dc1 and Dc1.1 in hydrophobic experimental conditions.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>EISSN: 1029-2349</identifier><identifier>DOI: 10.1080/14786419.2017.1346646</identifier><identifier>PMID: 28659061</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Amphibians ; analogues ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antibacterial activity ; Antimicrobial Cationic Peptides - chemistry ; Antimicrobial Cationic Peptides - pharmacology ; antimicrobial peptide ; Antimicrobial peptides ; Anura ; Anuran ; Chemical Sciences ; Colombia ; Cytotoxicity ; dendropsophin ; Dendropsophus columbianus ; Drug Evaluation, Preclinical - methods ; Fungi ; Hemolysis - drug effects ; Hemolytic Agents - chemistry ; Hemolytic Agents - pharmacology ; High-performance liquid chromatography ; Humans ; Hydrophobic and Hydrophilic Interactions ; Hydrophobicity ; Life Sciences ; Liquid chromatography ; Male ; Mammalian cells ; Mammals ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology and Parasitology ; Parasitology ; Peptides ; Pharmaceutical sciences ; Pharmacology ; Protein Stability ; Protein Structure, Secondary ; Protozoa ; Rats ; Secretion ; Sequence Homology, Amino Acid ; Skin ; Skin - secretion ; Spectroscopy ; Thermal stability ; Trypanosoma - drug effects</subject><ispartof>Natural product research, 2018-06, Vol.32 (12), p.1383-1389</ispartof><rights>2017 Informa UK Limited, trading as Taylor & Francis Group 2017</rights><rights>2017 Informa UK Limited, trading as Taylor & Francis Group</rights><rights>Attribution - NonCommercial - NoDerivatives</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-c6437e1de3e9398199f8a350020ad01d1e2d55e7a03f8177bc3809ab840ac6a73</citedby><cites>FETCH-LOGICAL-c428t-c6437e1de3e9398199f8a350020ad01d1e2d55e7a03f8177bc3809ab840ac6a73</cites><orcidid>0000-0002-9364-7289 ; 0000-0003-4153-0465</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28659061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01966411$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Triana-Vidal, Luz Elena</creatorcontrib><creatorcontrib>Castro, Mariana Souza</creatorcontrib><creatorcontrib>Pires Júnior, Osmindo Rodrigues</creatorcontrib><creatorcontrib>Álvares, Alice Cunha Morales</creatorcontrib><creatorcontrib>de Freitas, Sonia Maria</creatorcontrib><creatorcontrib>Fontes, Wagner</creatorcontrib><creatorcontrib>Vargas, Jimmy Alexander Guerrero</creatorcontrib><creatorcontrib>Zúñiga-Baos, Jorge Alberto</creatorcontrib><creatorcontrib>Correia Batista, Isabel de Fátima</creatorcontrib><creatorcontrib>Grellier, Philippe</creatorcontrib><creatorcontrib>Charneau, Sébastien</creatorcontrib><title>Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>In efforts to find new antimicrobial peptides (AMPs), we studied the skin secretion of the endemic Colombian frog Dendropsophus columbianus belonging to a genus that has not been investigated previously. From HPLC-fractionated secretion, we identified one peptide with slightly antibacterial activity. Its peptide sequence showed no sequence similarity to current annotated peptides. We named this novel peptide dendropsophin 1 (Dc1). Afterward, two analogues were designed (Dc1.1 and Dc1.2) to improve the cationic and amphipathic features. Then, their antiproliferative and cytotoxic properties were evaluated against several pathogens including bacteria, fungi, protozoa and also mammalian cells. Dc1 and its two analogues exhibited moderate antibacterial activities and no hemolytic and cytotoxic effects on mammalian cells. Analogue Dc1.2 showed slightly improved antibacterial properties. Their secondary structures were characterised using CD spectroscopy and Dc1.2 displayed a higher α-helix content and thermal stability compared to Dc1 and Dc1.1 in hydrophobic experimental conditions.</description><subject>Amphibians</subject><subject>analogues</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antimicrobial Cationic Peptides - chemistry</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>antimicrobial peptide</subject><subject>Antimicrobial peptides</subject><subject>Anura</subject><subject>Anuran</subject><subject>Chemical Sciences</subject><subject>Colombia</subject><subject>Cytotoxicity</subject><subject>dendropsophin</subject><subject>Dendropsophus columbianus</subject><subject>Drug Evaluation, Preclinical - 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secretion</subject><subject>Spectroscopy</subject><subject>Thermal stability</subject><subject>Trypanosoma - drug effects</subject><issn>1478-6419</issn><issn>1478-6427</issn><issn>1029-2349</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhiMEoqXwE0CWuIDELp74I_aNavko0kpc4Gx5kwnr4tjBTop64bfjdLcrxIGTrfHzvuOZt6qeA10DVfQt8EZJDnpdU2jWwLiUXD6ozpf6SvK6eXi6gz6rnuR8TWkNQojH1VmtpNBUwnn1-z2GLsUxx3HvAoE3xJIQb9ATGyY3uDbFnbOejDhOrkPSpziQaY8k_yh4xjbh5GIgsb-rFjMsIrKJPg5FGBbBd_JXkzmTNvr57nHOT6tHvfUZnx3Pi-rbxw9fN1er7ZdPnzeX21XLazWtWslZg9AhQ820Aq17ZZkoA1HbUegA604IbCxlvYKm2bVMUW13ilPbStuwi-r1wXdvvRmTG2y6NdE6c3W5NUuNgi4LBLiBwr46sGOKP2fMkxlcbtF7GzDO2YAGrrhUnBf05T_odZxTKJOYmnLaMKnFQokDVZaZc8L-9AOgZgnT3IdpljDNMcyie3F0n3cDdifVfXoFeHcAXOhjGuyvmHxnJnvrY-qTDa3Lhv2_xx8tHK3i</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Triana-Vidal, Luz Elena</creator><creator>Castro, Mariana Souza</creator><creator>Pires Júnior, Osmindo Rodrigues</creator><creator>Álvares, Alice Cunha Morales</creator><creator>de Freitas, Sonia Maria</creator><creator>Fontes, Wagner</creator><creator>Vargas, Jimmy Alexander Guerrero</creator><creator>Zúñiga-Baos, Jorge Alberto</creator><creator>Correia Batista, Isabel de Fátima</creator><creator>Grellier, Philippe</creator><creator>Charneau, Sébastien</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9364-7289</orcidid><orcidid>https://orcid.org/0000-0003-4153-0465</orcidid></search><sort><creationdate>201806</creationdate><title>Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus</title><author>Triana-Vidal, Luz Elena ; Castro, Mariana Souza ; Pires Júnior, Osmindo Rodrigues ; Álvares, Alice Cunha Morales ; de Freitas, Sonia Maria ; Fontes, Wagner ; Vargas, Jimmy Alexander Guerrero ; Zúñiga-Baos, Jorge Alberto ; Correia Batista, Isabel de Fátima ; Grellier, Philippe ; Charneau, Sébastien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-c6437e1de3e9398199f8a350020ad01d1e2d55e7a03f8177bc3809ab840ac6a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amphibians</topic><topic>analogues</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Triana-Vidal, Luz Elena</au><au>Castro, Mariana Souza</au><au>Pires Júnior, Osmindo Rodrigues</au><au>Álvares, Alice Cunha Morales</au><au>de Freitas, Sonia Maria</au><au>Fontes, Wagner</au><au>Vargas, Jimmy Alexander Guerrero</au><au>Zúñiga-Baos, Jorge Alberto</au><au>Correia Batista, Isabel de Fátima</au><au>Grellier, Philippe</au><au>Charneau, Sébastien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2018-06</date><risdate>2018</risdate><volume>32</volume><issue>12</issue><spage>1383</spage><epage>1389</epage><pages>1383-1389</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><eissn>1029-2349</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>In efforts to find new antimicrobial peptides (AMPs), we studied the skin secretion of the endemic Colombian frog Dendropsophus columbianus belonging to a genus that has not been investigated previously. From HPLC-fractionated secretion, we identified one peptide with slightly antibacterial activity. Its peptide sequence showed no sequence similarity to current annotated peptides. We named this novel peptide dendropsophin 1 (Dc1). Afterward, two analogues were designed (Dc1.1 and Dc1.2) to improve the cationic and amphipathic features. Then, their antiproliferative and cytotoxic properties were evaluated against several pathogens including bacteria, fungi, protozoa and also mammalian cells. Dc1 and its two analogues exhibited moderate antibacterial activities and no hemolytic and cytotoxic effects on mammalian cells. Analogue Dc1.2 showed slightly improved antibacterial properties. Their secondary structures were characterised using CD spectroscopy and Dc1.2 displayed a higher α-helix content and thermal stability compared to Dc1 and Dc1.1 in hydrophobic experimental conditions.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28659061</pmid><doi>10.1080/14786419.2017.1346646</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9364-7289</orcidid><orcidid>https://orcid.org/0000-0003-4153-0465</orcidid></addata></record> |
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| subjects | Amphibians analogues Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial activity Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology antimicrobial peptide Antimicrobial peptides Anura Anuran Chemical Sciences Colombia Cytotoxicity dendropsophin Dendropsophus columbianus Drug Evaluation, Preclinical - methods Fungi Hemolysis - drug effects Hemolytic Agents - chemistry Hemolytic Agents - pharmacology High-performance liquid chromatography Humans Hydrophobic and Hydrophilic Interactions Hydrophobicity Life Sciences Liquid chromatography Male Mammalian cells Mammals Medicinal Chemistry Microbial Sensitivity Tests Microbiology and Parasitology Parasitology Peptides Pharmaceutical sciences Pharmacology Protein Stability Protein Structure, Secondary Protozoa Rats Secretion Sequence Homology, Amino Acid Skin Skin - secretion Spectroscopy Thermal stability Trypanosoma - drug effects |
| title | Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus |
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