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Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity
Trafficking of polymorphonuclear neutrophils (PMNs) during inflammation critically depends on the β2 integrins lymphocyte function–associated antigen 1 (LFA-1) (CD11a/CD18) and macrophage-1 antigen (CD11b/CD18). Here, we identify coronin 1A (Coro1A) as a novel regulator of β2 integrins that interact...
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| Published in: | Blood 2017-08, Vol.130 (7), p.847-858 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| container_title | Blood |
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| creator | Pick, Robert Begandt, Daniela Stocker, Thomas J. Salvermoser, Melanie Thome, Sarah Böttcher, Ralph T. Montanez, Eloi Harrison, Ute Forné, Ignasi Khandoga, Alexander G. Coletti, Raffaele Weckbach, Ludwig T. Brechtefeld, Doris Haas, Rainer Imhof, Axel Massberg, Steffen Sperandio, Markus Walzog, Barbara |
| description | Trafficking of polymorphonuclear neutrophils (PMNs) during inflammation critically depends on the β2 integrins lymphocyte function–associated antigen 1 (LFA-1) (CD11a/CD18) and macrophage-1 antigen (CD11b/CD18). Here, we identify coronin 1A (Coro1A) as a novel regulator of β2 integrins that interacts with the cytoplasmic tail of CD18 and is crucial for induction of PMN adhesion and postadhesion events, including adhesion strengthening, spreading, and migration under flow conditions. Transition of PMN rolling to firm adhesion critically depends on Coro1A by regulating the accumulation of high-affinity LFA-1 in focal zones of adherent cells. Defective integrin affinity regulation in the genetic absence of Coro1A impairs leukocyte adhesion and extravasation in inflamed cremaster muscle venules in comparison with control animals. In a Helicobacter pylori mouse infection model, PMN infiltration into the gastric mucosa is dramatically reduced in Coro1A−/− mice, resulting in an attenuated gastric inflammation. Thus, Coro1A represents an important novel player in integrin biology, with key functions in PMN trafficking during innate immunity.
•Coro1A is identified as a novel regulator of β2 integrins (CD11/CD18).•Coro1A controls PMN adhesion and postadhesion events in innate immunity. |
| doi_str_mv | 10.1182/blood-2016-11-749622 |
| format | article |
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•Coro1A is identified as a novel regulator of β2 integrins (CD11/CD18).•Coro1A controls PMN adhesion and postadhesion events in innate immunity.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2016-11-749622</identifier><identifier>PMID: 28615221</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - metabolism ; Actins - metabolism ; Animals ; Calcium Signaling ; CD18 Antigens - metabolism ; Cell Adhesion ; Cell Movement ; Gastritis - immunology ; Gastritis - microbiology ; Gastritis - pathology ; Helicobacter pylori - physiology ; Immunity, Innate ; Lymphocyte Function-Associated Antigen-1 - metabolism ; Macrophage-1 Antigen - metabolism ; Mice, Inbred C57BL ; Neutrophils - cytology ; Neutrophils - metabolism ; Receptors, G-Protein-Coupled - metabolism ; Rheology</subject><ispartof>Blood, 2017-08, Vol.130 (7), p.847-858</ispartof><rights>2017 American Society of Hematology</rights><rights>2017 by The American Society of Hematology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-32aa3b591c46f7621839d788184dd43ad2402d37cde26769a0dcfa58bbe6c9173</citedby><cites>FETCH-LOGICAL-c408t-32aa3b591c46f7621839d788184dd43ad2402d37cde26769a0dcfa58bbe6c9173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006497120330858$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,783,787,3556,27936,27937,45792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28615221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pick, Robert</creatorcontrib><creatorcontrib>Begandt, Daniela</creatorcontrib><creatorcontrib>Stocker, Thomas J.</creatorcontrib><creatorcontrib>Salvermoser, Melanie</creatorcontrib><creatorcontrib>Thome, Sarah</creatorcontrib><creatorcontrib>Böttcher, Ralph T.</creatorcontrib><creatorcontrib>Montanez, Eloi</creatorcontrib><creatorcontrib>Harrison, Ute</creatorcontrib><creatorcontrib>Forné, Ignasi</creatorcontrib><creatorcontrib>Khandoga, Alexander G.</creatorcontrib><creatorcontrib>Coletti, Raffaele</creatorcontrib><creatorcontrib>Weckbach, Ludwig T.</creatorcontrib><creatorcontrib>Brechtefeld, Doris</creatorcontrib><creatorcontrib>Haas, Rainer</creatorcontrib><creatorcontrib>Imhof, Axel</creatorcontrib><creatorcontrib>Massberg, Steffen</creatorcontrib><creatorcontrib>Sperandio, Markus</creatorcontrib><creatorcontrib>Walzog, Barbara</creatorcontrib><title>Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity</title><title>Blood</title><addtitle>Blood</addtitle><description>Trafficking of polymorphonuclear neutrophils (PMNs) during inflammation critically depends on the β2 integrins lymphocyte function–associated antigen 1 (LFA-1) (CD11a/CD18) and macrophage-1 antigen (CD11b/CD18). Here, we identify coronin 1A (Coro1A) as a novel regulator of β2 integrins that interacts with the cytoplasmic tail of CD18 and is crucial for induction of PMN adhesion and postadhesion events, including adhesion strengthening, spreading, and migration under flow conditions. Transition of PMN rolling to firm adhesion critically depends on Coro1A by regulating the accumulation of high-affinity LFA-1 in focal zones of adherent cells. Defective integrin affinity regulation in the genetic absence of Coro1A impairs leukocyte adhesion and extravasation in inflamed cremaster muscle venules in comparison with control animals. In a Helicobacter pylori mouse infection model, PMN infiltration into the gastric mucosa is dramatically reduced in Coro1A−/− mice, resulting in an attenuated gastric inflammation. Thus, Coro1A represents an important novel player in integrin biology, with key functions in PMN trafficking during innate immunity.
•Coro1A is identified as a novel regulator of β2 integrins (CD11/CD18).•Coro1A controls PMN adhesion and postadhesion events in innate immunity.</description><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - metabolism</subject><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Calcium Signaling</subject><subject>CD18 Antigens - metabolism</subject><subject>Cell Adhesion</subject><subject>Cell Movement</subject><subject>Gastritis - immunology</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter pylori - physiology</subject><subject>Immunity, Innate</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>Macrophage-1 Antigen - metabolism</subject><subject>Mice, Inbred C57BL</subject><subject>Neutrophils - cytology</subject><subject>Neutrophils - metabolism</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Rheology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kMGOFCEQhonRuLOrb2AMRw_bSgFD0xeTzURdk0286JnQUD2iNIzQvcm8vay9evREUfn-qtRHyCtgbwE0fzfGnH3HGagOoOvloDh_Qnaw57pjjLOnZMcYU50cerggl7X-YAyk4Pvn5IJr1TgOOzIecskpJAo319TSlO8x0lO0Zyy0dUNa8FhaMYYc8_F8TV1OS8mx0oRrK07fQ6RLsdMU3M-Qjlso2QVpmOc1heX8gjybbKz48vG9It8-fvh6uO3uvnz6fLi565xkeukEt1aM-wGcVFOvOGgx-F5r0NJ7KaznknEveueRq14Nlnk32b0eR1RugF5ckTfb3FPJv1asi5lDdRijTZjXamAAJkQvtGqo3FBXcq0FJ3MqYbblbICZB7vmj13zYLf9zWa3xV4_bljHGf2_0F-dDXi_AdjuvA9YTHUBk0MfCrrF-Bz-v-E39OmMGA</recordid><startdate>20170817</startdate><enddate>20170817</enddate><creator>Pick, Robert</creator><creator>Begandt, Daniela</creator><creator>Stocker, Thomas J.</creator><creator>Salvermoser, Melanie</creator><creator>Thome, Sarah</creator><creator>Böttcher, Ralph T.</creator><creator>Montanez, Eloi</creator><creator>Harrison, Ute</creator><creator>Forné, Ignasi</creator><creator>Khandoga, Alexander G.</creator><creator>Coletti, Raffaele</creator><creator>Weckbach, Ludwig T.</creator><creator>Brechtefeld, Doris</creator><creator>Haas, Rainer</creator><creator>Imhof, Axel</creator><creator>Massberg, Steffen</creator><creator>Sperandio, Markus</creator><creator>Walzog, Barbara</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170817</creationdate><title>Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity</title><author>Pick, Robert ; Begandt, Daniela ; Stocker, Thomas J. ; Salvermoser, Melanie ; Thome, Sarah ; Böttcher, Ralph T. ; Montanez, Eloi ; Harrison, Ute ; Forné, Ignasi ; Khandoga, Alexander G. ; Coletti, Raffaele ; Weckbach, Ludwig T. ; Brechtefeld, Doris ; Haas, Rainer ; Imhof, Axel ; Massberg, Steffen ; Sperandio, Markus ; Walzog, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-32aa3b591c46f7621839d788184dd43ad2402d37cde26769a0dcfa58bbe6c9173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - metabolism</topic><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Calcium Signaling</topic><topic>CD18 Antigens - metabolism</topic><topic>Cell Adhesion</topic><topic>Cell Movement</topic><topic>Gastritis - immunology</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter pylori - physiology</topic><topic>Immunity, Innate</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>Macrophage-1 Antigen - metabolism</topic><topic>Mice, Inbred C57BL</topic><topic>Neutrophils - cytology</topic><topic>Neutrophils - metabolism</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Rheology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pick, Robert</creatorcontrib><creatorcontrib>Begandt, Daniela</creatorcontrib><creatorcontrib>Stocker, Thomas J.</creatorcontrib><creatorcontrib>Salvermoser, Melanie</creatorcontrib><creatorcontrib>Thome, Sarah</creatorcontrib><creatorcontrib>Böttcher, Ralph T.</creatorcontrib><creatorcontrib>Montanez, Eloi</creatorcontrib><creatorcontrib>Harrison, Ute</creatorcontrib><creatorcontrib>Forné, Ignasi</creatorcontrib><creatorcontrib>Khandoga, Alexander G.</creatorcontrib><creatorcontrib>Coletti, Raffaele</creatorcontrib><creatorcontrib>Weckbach, Ludwig T.</creatorcontrib><creatorcontrib>Brechtefeld, Doris</creatorcontrib><creatorcontrib>Haas, Rainer</creatorcontrib><creatorcontrib>Imhof, Axel</creatorcontrib><creatorcontrib>Massberg, Steffen</creatorcontrib><creatorcontrib>Sperandio, Markus</creatorcontrib><creatorcontrib>Walzog, Barbara</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pick, Robert</au><au>Begandt, Daniela</au><au>Stocker, Thomas J.</au><au>Salvermoser, Melanie</au><au>Thome, Sarah</au><au>Böttcher, Ralph T.</au><au>Montanez, Eloi</au><au>Harrison, Ute</au><au>Forné, Ignasi</au><au>Khandoga, Alexander G.</au><au>Coletti, Raffaele</au><au>Weckbach, Ludwig T.</au><au>Brechtefeld, Doris</au><au>Haas, Rainer</au><au>Imhof, Axel</au><au>Massberg, Steffen</au><au>Sperandio, Markus</au><au>Walzog, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2017-08-17</date><risdate>2017</risdate><volume>130</volume><issue>7</issue><spage>847</spage><epage>858</epage><pages>847-858</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Trafficking of polymorphonuclear neutrophils (PMNs) during inflammation critically depends on the β2 integrins lymphocyte function–associated antigen 1 (LFA-1) (CD11a/CD18) and macrophage-1 antigen (CD11b/CD18). Here, we identify coronin 1A (Coro1A) as a novel regulator of β2 integrins that interacts with the cytoplasmic tail of CD18 and is crucial for induction of PMN adhesion and postadhesion events, including adhesion strengthening, spreading, and migration under flow conditions. Transition of PMN rolling to firm adhesion critically depends on Coro1A by regulating the accumulation of high-affinity LFA-1 in focal zones of adherent cells. Defective integrin affinity regulation in the genetic absence of Coro1A impairs leukocyte adhesion and extravasation in inflamed cremaster muscle venules in comparison with control animals. In a Helicobacter pylori mouse infection model, PMN infiltration into the gastric mucosa is dramatically reduced in Coro1A−/− mice, resulting in an attenuated gastric inflammation. Thus, Coro1A represents an important novel player in integrin biology, with key functions in PMN trafficking during innate immunity.
•Coro1A is identified as a novel regulator of β2 integrins (CD11/CD18).•Coro1A controls PMN adhesion and postadhesion events in innate immunity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28615221</pmid><doi>10.1182/blood-2016-11-749622</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism Actins - metabolism Animals Calcium Signaling CD18 Antigens - metabolism Cell Adhesion Cell Movement Gastritis - immunology Gastritis - microbiology Gastritis - pathology Helicobacter pylori - physiology Immunity, Innate Lymphocyte Function-Associated Antigen-1 - metabolism Macrophage-1 Antigen - metabolism Mice, Inbred C57BL Neutrophils - cytology Neutrophils - metabolism Receptors, G-Protein-Coupled - metabolism Rheology |
| title | Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity |
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