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Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are en...
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Published in: | Cancer research (Chicago, Ill.) Ill.), 2017-07, Vol.77 (13), p.3431-3441 |
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container_title | Cancer research (Chicago, Ill.) |
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creator | Barbazán, Jorge Alonso-Alconada, Lorena Elkhatib, Nadia Geraldo, Sara Gurchenkov, Vasily Glentis, Alexandros van Niel, Guillaume Palmulli, Roberta Fernández, Beatriz Viaño, Patricia Garcia-Caballero, Tomas López-López, Rafael Abal, Miguel Vignjevic, Danijela Matic |
description | The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bearing primary tumors and are also present in vessels from human livers affected with metastases. Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions. Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation
Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells.
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doi_str_mv | 10.1158/0008-5472.can-16-1917 |
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Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells.
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Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells.
.</description><subject>Animals</subject><subject>Blood vessels</subject><subject>Cancer</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Line, Tumor</subject><subject>Colonization</subject><subject>Deposits</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Extravasation</subject><subject>Fibronectin</subject><subject>Fibronectins - metabolism</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - pathology</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Metastasis</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Transendothelial and Transepithelial Migration</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkU1vFDEMhiMEotvCTwBF4sJlSpyP2cxxNWVppQUuhWuUSTw01exkSTJI_fdk1NIDliXL8vNa1mtC3gG7BFD6E2NMN0pu-aWzcwNtAx1sX5ANKKGbrZTqJdk8M2fkPOf72ipg6jU541qJlmu2IdMh_MFEv2KxuWbI9CbTvXVhCsUW9HR4oOUO6c7fYcLZIY0j7UNyy2RLmH_R2-UYE-1xmjItkf60eR0lug9DijO6CtErPMUcSn5DXo12yvj2qV6QH_vPt_11c_j-5abfHRqnGC-NRu9lp-2gHThgo0UPfuux65RqhVWy7YQd_Sh4Dd3KtrVyQESpdNWjEBfk4-PeU4q_F8zFHEN29UQ7Y1yygY5xYB1IqOiH_9D7uKS5XlcpLbjigstKqUfKpZhzwtGcUjja9GCAmfUdZrXarFabfvfNQGvWd1Td-6fty3BE_6z657_4C5Nthhs</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Barbazán, Jorge</creator><creator>Alonso-Alconada, Lorena</creator><creator>Elkhatib, Nadia</creator><creator>Geraldo, Sara</creator><creator>Gurchenkov, Vasily</creator><creator>Glentis, Alexandros</creator><creator>van Niel, Guillaume</creator><creator>Palmulli, Roberta</creator><creator>Fernández, Beatriz</creator><creator>Viaño, Patricia</creator><creator>Garcia-Caballero, Tomas</creator><creator>López-López, Rafael</creator><creator>Abal, Miguel</creator><creator>Vignjevic, Danijela Matic</creator><general>American Association for Cancer Research, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits</title><author>Barbazán, Jorge ; 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Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bearing primary tumors and are also present in vessels from human livers affected with metastases. Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions. Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation
Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells.
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subjects | Animals Blood vessels Cancer Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell Line, Tumor Colonization Deposits Endothelial cells Endothelium Extravasation Fibronectin Fibronectins - metabolism Humans Liver Liver Neoplasms - blood Liver Neoplasms - pathology Metastases Metastasis Mice Mice, Nude Neoplasm Metastasis Neoplastic Cells, Circulating - pathology Transendothelial and Transepithelial Migration Tumor cells Tumors |
title | Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits |
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