Changes in apolipoprotein B and oxidized low‐density lipoprotein levels in gingival crevicular fluids as a result of periodontal tissue conditions

Background and Objective Periodontal disease is a chronic inflammatory disease caused by bacterial infection that can lead to tooth loss. Gingival crevicular fluid can be collected easily and noninvasively. We previously discovered the presence of apolipoprotein B (apoB), the main constituent of low...

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Bibliographic Details
Published in:Journal of periodontal research 2017-06, Vol.52 (3), p.594-602
Main Authors: Ishizuka, M., Kato, R., Moriya, Y., Noguchi, E., Koide, Y., Inoue, S., Itabe, H., Yamamoto, M.
Format: Article
Language:English
Subjects:
Aged
Apolipoprotein B
Apolipoproteins
Apolipoproteins B - analysis
Chronic infection
Chronic Periodontitis - metabolism
Chronic Periodontitis - therapy
Cytokines
Cytokines - analysis
Dental Plaque Index
Dental Scaling
Dentistry
Female
Fluids
Gingiva
gingival crevicular fluid
Gingival Crevicular Fluid - chemistry
Humans
initial preparation
Lipoproteins, LDL - analysis
Low density lipoprotein
Male
Middle Aged
oxidized low‐density lipoprotein
Periodontal Index
Periodontitis
Population studies
Root Planing
Scaling
Teeth
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Summary:Background and Objective Periodontal disease is a chronic inflammatory disease caused by bacterial infection that can lead to tooth loss. Gingival crevicular fluid can be collected easily and noninvasively. We previously discovered the presence of apolipoprotein B (apoB), the main constituent of low‐density lipoprotein, and oxidized low‐density lipoprotein (oxLDL) in the gingival crevicular fluid of healthy subjects. In this study, we investigated whether periodontal conditions affect the levels of apoB and oxLDL in gingival crevicular fluid. Material and Methods The study population comprised 11 patients with chronic periodontitis. A pair of gingival crevicular fluid samples was collected from each patient at a healthy site and at a site with periodontitis (baseline samples). Thereafter, gingival crevicular fluid samples were collected from the same patients again at 4 and 8 wk after scaling and root planing (SRP). The levels of apoB, oxLDL, protein and cytokines in gingival crevicular fluid, in addition to gingival crevicular fluid volume, were measured. Results At baseline, the levels of apoB and oxLDL in gingival crevicular fluid were higher at the sites with periodontitis than at the healthy sites. The levels of apoB and oxLDL at periodontal sites decreased after SRP. The level of oxLDL in gingival crevicular fluid correlated well with the probing pocket depth. The oxLDL : apoB ratio in gingival crevicular fluid was significantly higher than that in plasma. Conclusions The levels of apoB and oxLDL in gingival crevicular fluid change according to the periodontal tissue conditions.
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12427