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Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging
Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. The synthesis of near‐infrared (...
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| Published in: | Advanced functional materials 2017-02, Vol.27 (8), p.np-n/a |
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| creator | Xie, Chen Zhen, Xu Lei, Qunli Ni, Ran Pu, Kanyi |
| description | Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. The synthesis of near‐infrared (NIR) absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogeneous nanoparticles for in vivo PA imaging is reported. As compared with their counterpart nanoparticles (SPN1) prepared through nanoprecipitation, SPAs generally have higher fluorescence quantum yields but similar size and PA brightness, making them superior over SPN1. Optical and simulation studies reveal that the poly(ethylene glycol) (PEG) grafting density plays a critical role in determining the packing of SP segments inside the core of nanoparticles, consequently affecting the optical properties. The small size and structurally stable nanostructure, in conjunction with a dense PEG shell, allow SPAs to passively target tumors of living mice after systemic administration, permitting both PA and fluorescence imaging of the tumors at signals that are ≈1.5‐fold higher than that of liver. This study thus not only provides the first generation of amphiphilic optically active polymers for PA imaging, but also highlights the molecular guidelines for the development of organic NIR imaging nanomaterials.
Near‐infrared absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogenous nanoparticles are synthesized. The small size and structurally stable nanostructure in conjunction with a dense poly(ethylene glycol) shell allow SPAs to passively target tumors of living mice after systemic administration, permitting both photoacoustic and fluorescence imaging of the tumors. |
| doi_str_mv | 10.1002/adfm.201605397 |
| format | article |
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Near‐infrared absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogenous nanoparticles are synthesized. The small size and structurally stable nanostructure in conjunction with a dense poly(ethylene glycol) shell allow SPAs to passively target tumors of living mice after systemic administration, permitting both photoacoustic and fluorescence imaging of the tumors.</description><identifier>ISSN: 1616-301X</identifier><identifier>EISSN: 1616-3028</identifier><identifier>DOI: 10.1002/adfm.201605397</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Brightness ; Chemical synthesis ; Fluorescence ; Grafting ; Imaging ; Lithosphere ; Liver ; Materials science ; Mice ; Nanomaterials ; Nanoparticles ; Nanostructure ; Near infrared radiation ; Optical activity ; Optical properties ; photoacoustic imaging ; Polyethylene glycol ; polymer amphiphiles ; Polymers ; Segments ; Self assembly ; Spas ; Synthesis (chemistry) ; Tumors</subject><ispartof>Advanced functional materials, 2017-02, Vol.27 (8), p.np-n/a</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4567-b522593424b1006ef2283fd35ab3186d47dac92fc39b1dbd937417e694f129703</citedby><cites>FETCH-LOGICAL-c4567-b522593424b1006ef2283fd35ab3186d47dac92fc39b1dbd937417e694f129703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadfm.201605397$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadfm.201605397$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids></links><search><creatorcontrib>Xie, Chen</creatorcontrib><creatorcontrib>Zhen, Xu</creatorcontrib><creatorcontrib>Lei, Qunli</creatorcontrib><creatorcontrib>Ni, Ran</creatorcontrib><creatorcontrib>Pu, Kanyi</creatorcontrib><title>Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging</title><title>Advanced functional materials</title><description>Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. The synthesis of near‐infrared (NIR) absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogeneous nanoparticles for in vivo PA imaging is reported. As compared with their counterpart nanoparticles (SPN1) prepared through nanoprecipitation, SPAs generally have higher fluorescence quantum yields but similar size and PA brightness, making them superior over SPN1. Optical and simulation studies reveal that the poly(ethylene glycol) (PEG) grafting density plays a critical role in determining the packing of SP segments inside the core of nanoparticles, consequently affecting the optical properties. The small size and structurally stable nanostructure, in conjunction with a dense PEG shell, allow SPAs to passively target tumors of living mice after systemic administration, permitting both PA and fluorescence imaging of the tumors at signals that are ≈1.5‐fold higher than that of liver. This study thus not only provides the first generation of amphiphilic optically active polymers for PA imaging, but also highlights the molecular guidelines for the development of organic NIR imaging nanomaterials.
Near‐infrared absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogenous nanoparticles are synthesized. The small size and structurally stable nanostructure in conjunction with a dense poly(ethylene glycol) shell allow SPAs to passively target tumors of living mice after systemic administration, permitting both photoacoustic and fluorescence imaging of the tumors.</description><subject>Brightness</subject><subject>Chemical synthesis</subject><subject>Fluorescence</subject><subject>Grafting</subject><subject>Imaging</subject><subject>Lithosphere</subject><subject>Liver</subject><subject>Materials science</subject><subject>Mice</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Near infrared radiation</subject><subject>Optical activity</subject><subject>Optical properties</subject><subject>photoacoustic imaging</subject><subject>Polyethylene glycol</subject><subject>polymer amphiphiles</subject><subject>Polymers</subject><subject>Segments</subject><subject>Self assembly</subject><subject>Spas</subject><subject>Synthesis (chemistry)</subject><subject>Tumors</subject><issn>1616-301X</issn><issn>1616-3028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRsFavnhe8eEnd2d187DFUq4WKhfp1W5LNbpuSZGs2UXLzJ_gb_SWmVBS8CAMzh-cdZh6EToGMgBB6kWSmHFECAfGZCPfQAAIIPEZotP8zw_MhOnJuTQiEIeMD9LTQhfl8_4id02VadNgavNBlrmyVtarJqyWe26IrdY3jcrPK-yq0w8bWeFrhx_zV4vnKNjZRtnVNrvC0TJZ96hgdmKRw-uS7D9HD5Op-fOPN7q6n43jmKe4HoZf6lPqCccrT_odAG0ojZjLmJymDKMh4mCVKUKOYSCFLM8FCDqEOBDdARUjYEJ3v9m5q-9Jq18gyd0oXRVLp_iIJUcQBfN_fomd_0LVt66q_ToKghDMKhPXUaEep2jpXayM3dV4mdSeByK1nufUsfzz3AbELvPVmun9oGV9Obn-zX0frgXk</recordid><startdate>20170223</startdate><enddate>20170223</enddate><creator>Xie, Chen</creator><creator>Zhen, Xu</creator><creator>Lei, Qunli</creator><creator>Ni, Ran</creator><creator>Pu, Kanyi</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20170223</creationdate><title>Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging</title><author>Xie, Chen ; Zhen, Xu ; Lei, Qunli ; Ni, Ran ; Pu, Kanyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4567-b522593424b1006ef2283fd35ab3186d47dac92fc39b1dbd937417e694f129703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Brightness</topic><topic>Chemical synthesis</topic><topic>Fluorescence</topic><topic>Grafting</topic><topic>Imaging</topic><topic>Lithosphere</topic><topic>Liver</topic><topic>Materials science</topic><topic>Mice</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>Near infrared radiation</topic><topic>Optical activity</topic><topic>Optical properties</topic><topic>photoacoustic imaging</topic><topic>Polyethylene glycol</topic><topic>polymer amphiphiles</topic><topic>Polymers</topic><topic>Segments</topic><topic>Self assembly</topic><topic>Spas</topic><topic>Synthesis (chemistry)</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Chen</creatorcontrib><creatorcontrib>Zhen, Xu</creatorcontrib><creatorcontrib>Lei, Qunli</creatorcontrib><creatorcontrib>Ni, Ran</creatorcontrib><creatorcontrib>Pu, Kanyi</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Chen</au><au>Zhen, Xu</au><au>Lei, Qunli</au><au>Ni, Ran</au><au>Pu, Kanyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging</atitle><jtitle>Advanced functional materials</jtitle><date>2017-02-23</date><risdate>2017</risdate><volume>27</volume><issue>8</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>1616-301X</issn><eissn>1616-3028</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. The synthesis of near‐infrared (NIR) absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogeneous nanoparticles for in vivo PA imaging is reported. As compared with their counterpart nanoparticles (SPN1) prepared through nanoprecipitation, SPAs generally have higher fluorescence quantum yields but similar size and PA brightness, making them superior over SPN1. Optical and simulation studies reveal that the poly(ethylene glycol) (PEG) grafting density plays a critical role in determining the packing of SP segments inside the core of nanoparticles, consequently affecting the optical properties. The small size and structurally stable nanostructure, in conjunction with a dense PEG shell, allow SPAs to passively target tumors of living mice after systemic administration, permitting both PA and fluorescence imaging of the tumors at signals that are ≈1.5‐fold higher than that of liver. This study thus not only provides the first generation of amphiphilic optically active polymers for PA imaging, but also highlights the molecular guidelines for the development of organic NIR imaging nanomaterials.
Near‐infrared absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self‐assemble into homogenous nanoparticles are synthesized. The small size and structurally stable nanostructure in conjunction with a dense poly(ethylene glycol) shell allow SPAs to passively target tumors of living mice after systemic administration, permitting both photoacoustic and fluorescence imaging of the tumors.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adfm.201605397</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brightness Chemical synthesis Fluorescence Grafting Imaging Lithosphere Liver Materials science Mice Nanomaterials Nanoparticles Nanostructure Near infrared radiation Optical activity Optical properties photoacoustic imaging Polyethylene glycol polymer amphiphiles Polymers Segments Self assembly Spas Synthesis (chemistry) Tumors |
| title | Self‐Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging |
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