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Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance
Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major conse...
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| Published in: | Environmental toxicology and chemistry 2017-02, Vol.36 (2), p.354-360 |
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| cites | cdi_FETCH-LOGICAL-c4893-7b82ef2876ffb42dc1b7430684cc869d38211b5a37e607529f6cc922c71da3273 |
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| container_title | Environmental toxicology and chemistry |
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| creator | Alderman, Sarah L. Lin, Feng Farrell, Anthony P. Kennedy, Christopher J. Gillis, Todd E. |
| description | Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. The sensitivity of early life‐stage salmon to dilbit and its specific cardiotoxic effects are unknown. Sockeye salmon parr were exposed to environmentally relevant concentrations of the water‐soluble fraction (WSF) of dilbit for 1 wk and 4 wk, followed by an examination of molecular, morphological, and organismal endpoints related to cardiotoxicity. We show that parr are sensitive to WSF of dilbit, with total polycyclic aromatic hydrocarbon (PAH) concentrations of 3.5 µg/L sufficient to induce a liver biomarker of PAH exposure, and total PAH of 16.4 µg/L and 66.7 µg/L inducing PAH biomarkers in the heart. Furthermore, WSF of dilbit induces concentration–dependent cardiac remodeling coincident with performance effects: fish exposed to 66.7 µg/L total PAH have relatively fewer myocytes and more collagen in the compact myocardium and impaired swimming performance at 4 wk, whereas the opposite changes occur in fish exposed to 3.5 µg/L total PAH. The results demonstrate cardiac sensitivity to dilbit exposure that could directly impact sockeye migratory success. Environ Toxicol Chem 2017;36:354–360. © 2016 SETAC |
| doi_str_mv | 10.1002/etc.3533 |
| format | article |
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This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. The sensitivity of early life‐stage salmon to dilbit and its specific cardiotoxic effects are unknown. Sockeye salmon parr were exposed to environmentally relevant concentrations of the water‐soluble fraction (WSF) of dilbit for 1 wk and 4 wk, followed by an examination of molecular, morphological, and organismal endpoints related to cardiotoxicity. We show that parr are sensitive to WSF of dilbit, with total polycyclic aromatic hydrocarbon (PAH) concentrations of 3.5 µg/L sufficient to induce a liver biomarker of PAH exposure, and total PAH of 16.4 µg/L and 66.7 µg/L inducing PAH biomarkers in the heart. Furthermore, WSF of dilbit induces concentration–dependent cardiac remodeling coincident with performance effects: fish exposed to 66.7 µg/L total PAH have relatively fewer myocytes and more collagen in the compact myocardium and impaired swimming performance at 4 wk, whereas the opposite changes occur in fish exposed to 3.5 µg/L total PAH. The results demonstrate cardiac sensitivity to dilbit exposure that could directly impact sockeye migratory success. Environ Toxicol Chem 2017;36:354–360. © 2016 SETAC</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.3533</identifier><identifier>PMID: 27328800</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animal Migration - drug effects ; Animals ; Aquatic ecosystems ; Biomarkers - metabolism ; Bitumen ; Crude oil ; Ecosystem ; Embryo, Nonmammalian - drug effects ; Fish ; Fresh Water ; Heart ; Heart - drug effects ; Heart - embryology ; Hydrocarbons ; Hydrocarbons - chemistry ; Hydrocarbons - toxicity ; Myocardium - metabolism ; Myocardium - pathology ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - pathology ; Oil and Gas Fields ; Petroleum - toxicity ; Polycyclic aromatic hydrocarbon ; Polycyclic Aromatic Hydrocarbons - toxicity ; Salmon ; Salmon - embryology ; Salmon - metabolism ; Salmon - physiology ; Salmonidae ; Solubility ; Swimming ; Toxicity ; Water Pollutants, Chemical - chemistry ; Water Pollutants, Chemical - toxicity ; Water pollution</subject><ispartof>Environmental toxicology and chemistry, 2017-02, Vol.36 (2), p.354-360</ispartof><rights>2016 SETAC</rights><rights>2016 SETAC.</rights><rights>2017 SETAC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4893-7b82ef2876ffb42dc1b7430684cc869d38211b5a37e607529f6cc922c71da3273</citedby><cites>FETCH-LOGICAL-c4893-7b82ef2876ffb42dc1b7430684cc869d38211b5a37e607529f6cc922c71da3273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.3533$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.3533$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27328800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alderman, Sarah L.</creatorcontrib><creatorcontrib>Lin, Feng</creatorcontrib><creatorcontrib>Farrell, Anthony P.</creatorcontrib><creatorcontrib>Kennedy, Christopher J.</creatorcontrib><creatorcontrib>Gillis, Todd E.</creatorcontrib><title>Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance</title><title>Environmental toxicology and chemistry</title><addtitle>Environ Toxicol Chem</addtitle><description>Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. The sensitivity of early life‐stage salmon to dilbit and its specific cardiotoxic effects are unknown. Sockeye salmon parr were exposed to environmentally relevant concentrations of the water‐soluble fraction (WSF) of dilbit for 1 wk and 4 wk, followed by an examination of molecular, morphological, and organismal endpoints related to cardiotoxicity. We show that parr are sensitive to WSF of dilbit, with total polycyclic aromatic hydrocarbon (PAH) concentrations of 3.5 µg/L sufficient to induce a liver biomarker of PAH exposure, and total PAH of 16.4 µg/L and 66.7 µg/L inducing PAH biomarkers in the heart. Furthermore, WSF of dilbit induces concentration–dependent cardiac remodeling coincident with performance effects: fish exposed to 66.7 µg/L total PAH have relatively fewer myocytes and more collagen in the compact myocardium and impaired swimming performance at 4 wk, whereas the opposite changes occur in fish exposed to 3.5 µg/L total PAH. The results demonstrate cardiac sensitivity to dilbit exposure that could directly impact sockeye migratory success. Environ Toxicol Chem 2017;36:354–360. © 2016 SETAC</description><subject>Animal Migration - drug effects</subject><subject>Animals</subject><subject>Aquatic ecosystems</subject><subject>Biomarkers - metabolism</subject><subject>Bitumen</subject><subject>Crude oil</subject><subject>Ecosystem</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Fish</subject><subject>Fresh Water</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart - embryology</subject><subject>Hydrocarbons</subject><subject>Hydrocarbons - chemistry</subject><subject>Hydrocarbons - toxicity</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Myocytes, Cardiac - pathology</subject><subject>Oil and Gas Fields</subject><subject>Petroleum - toxicity</subject><subject>Polycyclic aromatic hydrocarbon</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Salmon</subject><subject>Salmon - embryology</subject><subject>Salmon - metabolism</subject><subject>Salmon - physiology</subject><subject>Salmonidae</subject><subject>Solubility</subject><subject>Swimming</subject><subject>Toxicity</subject><subject>Water Pollutants, Chemical - chemistry</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water pollution</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQQBdRbK2Cv0AWvHhJ3Y9mP7xJaVUoeNGDp5BsZiE1ydbdRO2_d2NVRPA0l8ebmYfQKSVTSgi7hM5Mecr5HhrTNGWJElTtozGRnCSSCTVCRyGsCaFCa32IRkxyphQhY_S0sBZMF7CzuKzqvoMSF1XXN9BieN-40HvArsXr_hXaqgYcnHmGbZx53bj2Ci-9a7CBug64c3gD3jrf5K2BY3Rg8zrAydecoMfl4mF-m6zub-7m16vEzJTmiSwUA8uUFNYWM1YaWsgZJ0LNjFFCl1wxSos05xIEkSnTVhijGTOSljmPj0zQxc678e6lh9BlTRWGg_IWXB8yqoTiLC7QET3_g65d79t43UDRmDLVv4TGuxA82Gzjqyb324ySbMidxdzZkDuiZ1_Cvmig_AG_-0Yg2QFvsd32X1EWmU_hByRgh9I</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Alderman, Sarah L.</creator><creator>Lin, Feng</creator><creator>Farrell, Anthony P.</creator><creator>Kennedy, Christopher J.</creator><creator>Gillis, Todd E.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>201702</creationdate><title>Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance</title><author>Alderman, Sarah L. ; Lin, Feng ; Farrell, Anthony P. ; Kennedy, Christopher J. ; Gillis, Todd E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4893-7b82ef2876ffb42dc1b7430684cc869d38211b5a37e607529f6cc922c71da3273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal Migration - drug effects</topic><topic>Animals</topic><topic>Aquatic ecosystems</topic><topic>Biomarkers - metabolism</topic><topic>Bitumen</topic><topic>Crude oil</topic><topic>Ecosystem</topic><topic>Embryo, Nonmammalian - drug effects</topic><topic>Fish</topic><topic>Fresh Water</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Heart - embryology</topic><topic>Hydrocarbons</topic><topic>Hydrocarbons - chemistry</topic><topic>Hydrocarbons - toxicity</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Myocytes, Cardiac - pathology</topic><topic>Oil and Gas Fields</topic><topic>Petroleum - toxicity</topic><topic>Polycyclic aromatic hydrocarbon</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Salmon</topic><topic>Salmon - embryology</topic><topic>Salmon - metabolism</topic><topic>Salmon - physiology</topic><topic>Salmonidae</topic><topic>Solubility</topic><topic>Swimming</topic><topic>Toxicity</topic><topic>Water Pollutants, Chemical - chemistry</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alderman, Sarah L.</creatorcontrib><creatorcontrib>Lin, Feng</creatorcontrib><creatorcontrib>Farrell, Anthony P.</creatorcontrib><creatorcontrib>Kennedy, Christopher J.</creatorcontrib><creatorcontrib>Gillis, Todd E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alderman, Sarah L.</au><au>Lin, Feng</au><au>Farrell, Anthony P.</au><au>Kennedy, Christopher J.</au><au>Gillis, Todd E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environ Toxicol Chem</addtitle><date>2017-02</date><risdate>2017</risdate><volume>36</volume><issue>2</issue><spage>354</spage><epage>360</epage><pages>354-360</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. The sensitivity of early life‐stage salmon to dilbit and its specific cardiotoxic effects are unknown. Sockeye salmon parr were exposed to environmentally relevant concentrations of the water‐soluble fraction (WSF) of dilbit for 1 wk and 4 wk, followed by an examination of molecular, morphological, and organismal endpoints related to cardiotoxicity. We show that parr are sensitive to WSF of dilbit, with total polycyclic aromatic hydrocarbon (PAH) concentrations of 3.5 µg/L sufficient to induce a liver biomarker of PAH exposure, and total PAH of 16.4 µg/L and 66.7 µg/L inducing PAH biomarkers in the heart. Furthermore, WSF of dilbit induces concentration–dependent cardiac remodeling coincident with performance effects: fish exposed to 66.7 µg/L total PAH have relatively fewer myocytes and more collagen in the compact myocardium and impaired swimming performance at 4 wk, whereas the opposite changes occur in fish exposed to 3.5 µg/L total PAH. The results demonstrate cardiac sensitivity to dilbit exposure that could directly impact sockeye migratory success. Environ Toxicol Chem 2017;36:354–360. © 2016 SETAC</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27328800</pmid><doi>10.1002/etc.3533</doi><tpages>7</tpages></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2017-02, Vol.36 (2), p.354-360 |
| issn | 0730-7268 1552-8618 |
| language | eng |
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| source | Wiley-Blackwell Journals |
| subjects | Animal Migration - drug effects Animals Aquatic ecosystems Biomarkers - metabolism Bitumen Crude oil Ecosystem Embryo, Nonmammalian - drug effects Fish Fresh Water Heart Heart - drug effects Heart - embryology Hydrocarbons Hydrocarbons - chemistry Hydrocarbons - toxicity Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Oil and Gas Fields Petroleum - toxicity Polycyclic aromatic hydrocarbon Polycyclic Aromatic Hydrocarbons - toxicity Salmon Salmon - embryology Salmon - metabolism Salmon - physiology Salmonidae Solubility Swimming Toxicity Water Pollutants, Chemical - chemistry Water Pollutants, Chemical - toxicity Water pollution |
| title | Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance |
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