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Clear, Aqueous Topical Drop of Triamcinolone Acetonide
The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of triamcinolone acetonide (TA) with a combination of nonionic surfactant hydrogenated castor oil 60 (HCO-60) and octoxynol-40 (Oc-40). In order to delineate the effects of drug-polymer interactions on en...
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| Published in: | AAPS PharmSciTech 2017-10, Vol.18 (7), p.2466-2478 |
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| cites | cdi_FETCH-LOGICAL-c344t-73833a9dd700745443908d369325fd51c2094e61460785962a64b1ae5f1ff8bb3 |
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| container_issue | 7 |
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| container_title | AAPS PharmSciTech |
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| creator | Trinh, Hoang M. Cholkar, Kishore Joseph, Mary Yang, Xiaoyan Mitra, Ashim K. |
| description | The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of triamcinolone acetonide (TA) with a combination of nonionic surfactant hydrogenated castor oil 60 (HCO-60) and octoxynol-40 (Oc-40). In order to delineate the effects of drug-polymer interactions on entrapment efficiency (EE), loading efficiency (LE), and critical micellar concentration (CMC), a design of experiment (DOE) was performed to optimize the formulation. In this study, full-factorial design has been used with HCO-60 and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, EE, LE, and CMC. A specific blend of HCO-60 and Oc-40 at a particular wt% ratio (5:1.5) produced highest drug EE, LE, and smallest CMC (0.0216 wt%). Solubility of TA in NMF improved 20 times relative to normal aqueous solubility. Qualitative
1
H NMR studies confirmed the absence of free drug in the outer aqueous NMF medium. Moreover, TA-loaded NMF appeared to be highly stable and well tolerated on human corneal epithelial cells (HCEC) and human retinal pigment epithelial cells (D407 cells). Overall, these studies suggest that TA in NMF is safe and suitable for human topical ocular drop application. |
| doi_str_mv | 10.1208/s12249-017-0714-4 |
| format | article |
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1
H NMR studies confirmed the absence of free drug in the outer aqueous NMF medium. Moreover, TA-loaded NMF appeared to be highly stable and well tolerated on human corneal epithelial cells (HCEC) and human retinal pigment epithelial cells (D407 cells). Overall, these studies suggest that TA in NMF is safe and suitable for human topical ocular drop application.</description><identifier>ISSN: 1530-9932</identifier><identifier>EISSN: 1530-9932</identifier><identifier>DOI: 10.1208/s12249-017-0714-4</identifier><identifier>PMID: 28185211</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Pharmacology/Toxicology ; Pharmacy ; Research Article</subject><ispartof>AAPS PharmSciTech, 2017-10, Vol.18 (7), p.2466-2478</ispartof><rights>American Association of Pharmaceutical Scientists 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-73833a9dd700745443908d369325fd51c2094e61460785962a64b1ae5f1ff8bb3</citedby><cites>FETCH-LOGICAL-c344t-73833a9dd700745443908d369325fd51c2094e61460785962a64b1ae5f1ff8bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28185211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trinh, Hoang M.</creatorcontrib><creatorcontrib>Cholkar, Kishore</creatorcontrib><creatorcontrib>Joseph, Mary</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Mitra, Ashim K.</creatorcontrib><title>Clear, Aqueous Topical Drop of Triamcinolone Acetonide</title><title>AAPS PharmSciTech</title><addtitle>AAPS PharmSciTech</addtitle><addtitle>AAPS PharmSciTech</addtitle><description>The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of triamcinolone acetonide (TA) with a combination of nonionic surfactant hydrogenated castor oil 60 (HCO-60) and octoxynol-40 (Oc-40). In order to delineate the effects of drug-polymer interactions on entrapment efficiency (EE), loading efficiency (LE), and critical micellar concentration (CMC), a design of experiment (DOE) was performed to optimize the formulation. In this study, full-factorial design has been used with HCO-60 and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, EE, LE, and CMC. A specific blend of HCO-60 and Oc-40 at a particular wt% ratio (5:1.5) produced highest drug EE, LE, and smallest CMC (0.0216 wt%). Solubility of TA in NMF improved 20 times relative to normal aqueous solubility. Qualitative
1
H NMR studies confirmed the absence of free drug in the outer aqueous NMF medium. Moreover, TA-loaded NMF appeared to be highly stable and well tolerated on human corneal epithelial cells (HCEC) and human retinal pigment epithelial cells (D407 cells). Overall, these studies suggest that TA in NMF is safe and suitable for human topical ocular drop application.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><issn>1530-9932</issn><issn>1530-9932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EoqXwA7igHDkQ8PoR28eq5SVV4lLOlpPYKFUSB7s58O9xlYI4cdqVdmY0-yF0DfgeCJYPEQhhKscgciyA5ewEzYFTnCtFyemffYYuYtxhTCgoeo5mRILkBGCOilVrTbjLlp-j9WPMtn5oKtNm6-CHzLtsGxrTVU3vW9_bbFnZve-b2l6iM2faaK-Oc4Henx63q5d88_b8ulpu8ooyts8FlZQaVdcCY8E4Y1RhWdMiVeKu5lARrJgtgBVYSK4KYgpWgrHcgXOyLOkC3U65Q_CpYdzrromVbVvTH-pqkIXgDBgVSQqTtAo-xmCdHkLTmfClAesDLj3h0gmXPuDSLHlujvFj2dn61_HDJwnIJIjp1H_YoHd-DH16-Z_UbwqPclE</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Trinh, Hoang M.</creator><creator>Cholkar, Kishore</creator><creator>Joseph, Mary</creator><creator>Yang, Xiaoyan</creator><creator>Mitra, Ashim K.</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Clear, Aqueous Topical Drop of Triamcinolone Acetonide</title><author>Trinh, Hoang M. ; Cholkar, Kishore ; Joseph, Mary ; Yang, Xiaoyan ; Mitra, Ashim K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-73833a9dd700745443908d369325fd51c2094e61460785962a64b1ae5f1ff8bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trinh, Hoang M.</creatorcontrib><creatorcontrib>Cholkar, Kishore</creatorcontrib><creatorcontrib>Joseph, Mary</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Mitra, Ashim K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AAPS PharmSciTech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trinh, Hoang M.</au><au>Cholkar, Kishore</au><au>Joseph, Mary</au><au>Yang, Xiaoyan</au><au>Mitra, Ashim K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clear, Aqueous Topical Drop of Triamcinolone Acetonide</atitle><jtitle>AAPS PharmSciTech</jtitle><stitle>AAPS PharmSciTech</stitle><addtitle>AAPS PharmSciTech</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>18</volume><issue>7</issue><spage>2466</spage><epage>2478</epage><pages>2466-2478</pages><issn>1530-9932</issn><eissn>1530-9932</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of triamcinolone acetonide (TA) with a combination of nonionic surfactant hydrogenated castor oil 60 (HCO-60) and octoxynol-40 (Oc-40). In order to delineate the effects of drug-polymer interactions on entrapment efficiency (EE), loading efficiency (LE), and critical micellar concentration (CMC), a design of experiment (DOE) was performed to optimize the formulation. In this study, full-factorial design has been used with HCO-60 and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, EE, LE, and CMC. A specific blend of HCO-60 and Oc-40 at a particular wt% ratio (5:1.5) produced highest drug EE, LE, and smallest CMC (0.0216 wt%). Solubility of TA in NMF improved 20 times relative to normal aqueous solubility. Qualitative
1
H NMR studies confirmed the absence of free drug in the outer aqueous NMF medium. Moreover, TA-loaded NMF appeared to be highly stable and well tolerated on human corneal epithelial cells (HCEC) and human retinal pigment epithelial cells (D407 cells). Overall, these studies suggest that TA in NMF is safe and suitable for human topical ocular drop application.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28185211</pmid><doi>10.1208/s12249-017-0714-4</doi><tpages>13</tpages></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Pharmacology/Toxicology Pharmacy Research Article |
| title | Clear, Aqueous Topical Drop of Triamcinolone Acetonide |
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