Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey

Background To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan. Methods We conducted a retrospective cohort study between 2011 and 2014 in member instituti...

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Bibliographic Details
Published in:International journal of clinical oncology 2017-06, Vol.22 (3), p.541-547
Main Authors: Tokunaga, Hideki, Takahashi, Fumiaki, Yamamoto, Hiroki, Honda, Tsuyoshi, Watanabe, Takafumi, Shoji, Tadahiro, Sugiyama, Toru, Yamada, Hidekazu, Tando, Tomoe, Yoshinaga, Kosuke, Kagabu, Satoko, Otsuki, Takeo, Kin, Shogo, Yokoyama, Yoshihito, Wagatsuma, Satoshige, Sato, Kazuyo, Sato, Hirokazu, Oishi, Takashi, Yoshida, Yuji, Hayasaka, Tadashi, Matsui, Toshihiko, Imai, Noriaki, Nishigori, Hidekazu, Shimokawa, Hiroaki, Yaegashi, Nobuo, Watanabe, Yoh
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer Research
Chemotherapy
Combined Modality Therapy
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Disease-Free Survival
Female
Gemcitabine
Health Surveys
Humans
Japan - epidemiology
Leiomyosarcoma - pathology
Lymph Node Excision - statistics & numerical data
Malignancy
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - pathology
Oncology
Original Article
Post-menopause
Prognosis
Retrospective Studies
Surgery
Surgical Oncology
Survival
Taxoids - administration & dosage
Translation
Uterine cancer
Uterine Neoplasms - mortality
Uterine Neoplasms - pathology
Uterine Neoplasms - therapy
Uterus
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Description
Summary:Background To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan. Methods We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network. Results A total of 53 patients with ULMS were registered in 31 institutions for the present survey. The median patient age was 56 years, 67.9% of the patients were postmenopausal, 88.7% had a performance status of 0 or 1, and only 6 patients (11.3%) showed preoperative evidence of malignancy. Although retroperitoneal lymphadenectomy was performed in only 26.4% of patients, 64.2% patients were identified as having FIGO stage 1 disease; 73.6% were eligible to undergo complete surgery. Among 36 patients who were treated with postoperative chemotherapy, 28 (77.8%) received docetaxel and gemcitabine combination therapy. The most frequent recurrence site was the lungs, and the median progression-free survival of all enrolled patients was 11.7 months. However, the median progression-free survival and the median overall survival in patients with stages III and IV disease were 3.4 and 11.4 months, respectively. Conclusion Although ULMS was associated with a high rate of complete or optimal surgery, the long-term prognosis was poor. Effective postoperative therapy should be developed to improve the long-term prognosis of patients with ULMS.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-017-1097-y