Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats

The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence...

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Published in:Analytical chemistry (Washington) 2016-11, Vol.88 (22), p.10775-10784
Main Authors: Petras, Daniel, Nothias, Louis-Félix, Quinn, Robert A, Alexandrov, Theodore, Bandeira, Nuno, Bouslimani, Amina, Castro-Falcón, Gabriel, Chen, Liangyu, Dang, Tam, Floros, Dimitrios J, Hook, Vivian, Garg, Neha, Hoffner, Nicole, Jiang, Yike, Kapono, Clifford A, Koester, Irina, Knight, Rob, Leber, Christopher A, Ling, Tie-Jun, Luzzatto-Knaan, Tal, McCall, Laura-Isobel, McGrath, Aaron P, Meehan, Michael J, Merritt, Jonathan K, Mills, Robert H, Morton, Jamie, Podvin, Sonia, Protsyuk, Ivan, Purdy, Trevor, Satterfield, Kendall, Searles, Stephen, Shah, Sahil, Shires, Sarah, Steffen, Dana, White, Margot, Todoric, Jelena, Tuttle, Robert, Wojnicz, Aneta, Sapp, Valerie, Vargas, Fernando, Yang, Jin, Zhang, Chao, Dorrestein, Pieter C
Format: Article
Language:English
Subjects:
Analytical chemistry
Bicycles
Chemicals
Chromatography
Chromatography, Liquid
Ecosystem
Fingerprints
Foods
Habitats
Humans
Ions - analysis
Mapping
Mass Spectrometry
Molecules
Offices
Organic Chemicals - analysis
Organic Chemicals - chemistry
Plasticizers
Tandem Mass Spectrometry
Urban environments
Visualization
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cited_by cdi_FETCH-LOGICAL-a455t-50ab1e487cb3852b97f57b37ffdba70a93e0e59c05c4fee891c5ff36750d9e7e3
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container_end_page 10784
container_issue 22
container_start_page 10775
container_title Analytical chemistry (Washington)
container_volume 88
creator Petras, Daniel
Nothias, Louis-Félix
Quinn, Robert A
Alexandrov, Theodore
Bandeira, Nuno
Bouslimani, Amina
Castro-Falcón, Gabriel
Chen, Liangyu
Dang, Tam
Floros, Dimitrios J
Hook, Vivian
Garg, Neha
Hoffner, Nicole
Jiang, Yike
Kapono, Clifford A
Koester, Irina
Knight, Rob
Leber, Christopher A
Ling, Tie-Jun
Luzzatto-Knaan, Tal
McCall, Laura-Isobel
McGrath, Aaron P
Meehan, Michael J
Merritt, Jonathan K
Mills, Robert H
Morton, Jamie
Podvin, Sonia
Protsyuk, Ivan
Purdy, Trevor
Satterfield, Kendall
Searles, Stephen
Shah, Sahil
Shires, Sarah
Steffen, Dana
White, Margot
Todoric, Jelena
Tuttle, Robert
Wojnicz, Aneta
Sapp, Valerie
Vargas, Fernando
Yang, Jin
Zhang, Chao
Dorrestein, Pieter C
description The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.
doi_str_mv 10.1021/acs.analchem.6b03456
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Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petras, Daniel</au><au>Nothias, Louis-Félix</au><au>Quinn, Robert A</au><au>Alexandrov, Theodore</au><au>Bandeira, Nuno</au><au>Bouslimani, Amina</au><au>Castro-Falcón, Gabriel</au><au>Chen, Liangyu</au><au>Dang, Tam</au><au>Floros, Dimitrios J</au><au>Hook, Vivian</au><au>Garg, Neha</au><au>Hoffner, Nicole</au><au>Jiang, Yike</au><au>Kapono, Clifford A</au><au>Koester, Irina</au><au>Knight, Rob</au><au>Leber, Christopher A</au><au>Ling, Tie-Jun</au><au>Luzzatto-Knaan, Tal</au><au>McCall, Laura-Isobel</au><au>McGrath, Aaron P</au><au>Meehan, Michael J</au><au>Merritt, Jonathan K</au><au>Mills, Robert H</au><au>Morton, Jamie</au><au>Podvin, Sonia</au><au>Protsyuk, Ivan</au><au>Purdy, Trevor</au><au>Satterfield, Kendall</au><au>Searles, Stephen</au><au>Shah, Sahil</au><au>Shires, Sarah</au><au>Steffen, Dana</au><au>White, Margot</au><au>Todoric, Jelena</au><au>Tuttle, Robert</au><au>Wojnicz, Aneta</au><au>Sapp, Valerie</au><au>Vargas, Fernando</au><au>Yang, Jin</au><au>Zhang, Chao</au><au>Dorrestein, Pieter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2016-11-15</date><risdate>2016</risdate><volume>88</volume><issue>22</issue><spage>10775</spage><epage>10784</epage><pages>10775-10784</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The cars we drive, the homes we live in, the restaurants we visit, and the laboratories and offices we work in are all a part of the modern human habitat. Remarkably, little is known about the diversity of chemicals present in these environments and to what degree molecules from our bodies influence the built environment that surrounds us and vice versa. We therefore set out to visualize the chemical diversity of five built human habitats together with their occupants, to provide a snapshot of the various molecules to which humans are exposed on a daily basis. The molecular inventory was obtained through untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of samples from each human habitat and from the people that occupy those habitats. Mapping MS-derived data onto 3D models of the environments showed that frequently touched surfaces, such as handles (e.g., door, bicycle), resemble the molecular fingerprint of the human skin more closely than other surfaces that are less frequently in direct contact with humans (e.g., wall, bicycle frame). Approximately 50% of the MS/MS spectra detected were shared between people and the environment. Personal care products, plasticizers, cleaning supplies, food, food additives, and even medications that were found to be a part of the human habitat. The annotations indicate that significant transfer of chemicals takes place between us and our built environment. The workflows applied here will lay the foundation for future studies of molecular distributions in medical, forensic, architectural, space exploration, and environmental applications.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27732780</pmid><doi>10.1021/acs.analchem.6b03456</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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ispartof Analytical chemistry (Washington), 2016-11, Vol.88 (22), p.10775-10784
issn 0003-2700
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language eng
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Analytical chemistry
Bicycles
Chemicals
Chromatography
Chromatography, Liquid
Ecosystem
Fingerprints
Foods
Habitats
Humans
Ions - analysis
Mapping
Mass Spectrometry
Molecules
Offices
Organic Chemicals - analysis
Organic Chemicals - chemistry
Plasticizers
Tandem Mass Spectrometry
Urban environments
Visualization
title Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats
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