Quantitative T2 mapping for detection and quantification of thrombophlebitis in a rabbit model

Abstract Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for...

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Bibliographic Details
Published in:Journal of biomechanics 2017-01, Vol.50, p.151-157
Main Authors: Weiss, Dar, Rotman, Oren M, Einav, Shmuel
Format: Article
Language:English
Subjects:
Acclimatization
Alcohols
Amiodarone
Anesthesia
Animals
Biocompatibility
Biomechanics
Biotechnology
Brain
Brain injury
Breathing
Cardiovascular diseases
Catheterization
Catheterization, Peripheral - adverse effects
Catheters
Catheters - adverse effects
Cerebral infarction
Chemical composition
Clinical trials
Coagulation
Collars
Design
Diagnosis
Disease Models, Animal
Disinfectants
Ear
Edema
Environmental monitoring
Evaluation
Female
Heart
Heart attacks
Heart diseases
Histopathology
Incidence
Infections
Inflammation
Injection
Lesions
Magnetic Resonance Imaging
Mathematical models
Medical devices
Medical equipment
Medical instruments
MRI
Myocardial infarction
Neuroimaging
NMR
Nuclear magnetic resonance
Nursing
Pain
Peripheral catheter
Physical Medicine and Rehabilitation
Qualitative analysis
Quality
Quantitation
Quantitative analysis
Rabbits
Respiration
Risk factors
Robustness (mathematics)
Safety
Side effects
Slopes
Stroke
Temperature effects
Thrombophlebitis
Thrombophlebitis - diagnostic imaging
Thrombophlebitis - etiology
Thrombophlebitis - pathology
Veins & arteries
Veins - diagnostic imaging
Veins - pathology
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Description
Summary:Abstract Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design. In this study, we developed for the first time a quantitative MRI based tool for evaluation of SPCT. The extent and severity of SPCT caused by two different commercially available SPCs with known predisposition for thrombophlebitis, were studied in a rabbit model. MRI analysis was consistent with the standardized pathology evaluation and showed remarkable difference in the percent of edema between the experimental groups. These differences were in line with previous studies and provide evidence that this type of analysis may be useful for future assessment of SPCT in vivo . As a non-invasive method, it may constitute a cost effective solution for examination of new catheters and other medical devices, thereby reducing the need for animal sacrifice.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2016.11.021